Effectiveness of Nanometer-Sized Extracellular Matrix Layer-by-Layer Assembled Films for a Cell Membrane Coating Protecting Cells from Physical Stress

Langmuir ◽  
2012 ◽  
Vol 29 (24) ◽  
pp. 7362-7368 ◽  
Author(s):  
Atsushi Matsuzawa ◽  
Michiya Matsusaki ◽  
Mitsuru Akashi
Keyword(s):  
Extracellular Matrix ◽  
Cell Membrane ◽  
Physical Stress ◽  
Layer By Layer ◽  
Matrix Layer ◽  
A Cell ◽  
Membrane Coating

Feasibility Study for Applying Irreversible Electroporation to the Treatment of Breast Cancer

2009 ◽  
Author(s):  
Robert E. Neal ◽  
Ravi Singh ◽  
Suzy Torti ◽  
Rafael V. Davalos
Keyword(s):  
Breast Cancer ◽  
Immune Response ◽  
Extracellular Matrix ◽  
Numerical Modeling ◽  
Cell Membrane ◽  
Irreversible Electroporation ◽  
Short Length ◽  
Tissue Ablation ◽  
Electric Pulses ◽  
A Cell

Non-thermal irreversible electroporation (IRE) is a new, minimally invasive, localized tissue ablation technique [1]. The procedure uses electrodes to deliver short-length, high voltage electric pulses to destabilize a cell membrane, leading to the creation of nanopores. When the pulses are strong enough, the cell cannot repair the damage and dies [2]. It has been shown that substantial volumes of tissue and cutaneous tumors may be ablated in a non-thermal manner using irreversible electroporation [1, 3]. In addition, this procedure may be predicted by numerical modeling, promotes an immune response, leaves the extracellular matrix intact, does not affect nerves, may be monitored in real-time, and preserves tissue vasculature [2–5].

scholarly journals Recent Advances of Cell Membrane Coated Nanoparticles in Treating Cardiovascular Disorders

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3428
Author(s):  
Chaojie Zhu ◽  
Junkai Ma ◽  
Zhiheng Ji ◽  
Jie Shen ◽  
Qiwen Wang
Keyword(s):  
Cardiovascular Diseases ◽  
Cell Membrane ◽  
Preventive Therapy ◽  
Peripheral Vascular ◽  
Coating Technology ◽  
Immune Clearance ◽  
Coated Nanoparticles ◽  
Membrane Coating ◽  
Therapeutic Tools

Cardiovascular diseases (CVDs) are the leading cause of death worldwide, causing approximately 17.9 million deaths annually, an estimated 31% of all deaths, according to the WHO. CVDs are essentially rooted in atherosclerosis and are clinically classified into coronary heart disease, stroke and peripheral vascular disorders. Current clinical interventions include early diagnosis, the insertion of stents, and long-term preventive therapy. However, clinical diagnostic and therapeutic tools are subject to a number of limitations including, but not limited to, potential toxicity induced by contrast agents and unexpected bleeding caused by anti-platelet drugs. Nanomedicine has achieved great advancements in biomedical area. Among them, cell membrane coated nanoparticles, denoted as CMCNPs, have acquired enormous expectations due to their biomimetic properties. Such membrane coating technology not only helps avoid immune clearance, but also endows nanoparticles with diverse cellular and functional mimicry. In this review, we will describe the superiorities of CMCNPs in treating cardiovascular diseases and their potentials in optimizing current clinical managements.

Hybrid-cell membrane-coated nanocomplex-loaded chikusetsusaponin IVa methyl ester for a combinational therapy against breast cancer assisted by Ce6

2021 ◽  
Vol 9 (8) ◽  
pp. 2991-3004
Author(s):  
Qian Xie ◽  
Yang Liu ◽  
Ying Long ◽  
Zhou Wang ◽  
Sai Jiang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Methyl Ester ◽  
Cell Membrane ◽  
Hybrid Cell ◽  
Combinational Therapy ◽  
Membrane Coating

Hybrid-cell membrane coating nanocomplexes loading chikusetsusaponin IVa methyl ester for combinational therapy against breast cancer assisted with Ce6.

Laser-generated bubbles take aim at a cell membrane

Physics Today ◽  
2010 ◽  
Vol 63 (9) ◽  
pp. 17-17
Author(s):  
Mark Wilson
Keyword(s):  
Cell Membrane ◽  
A Cell

Line tension and the penetration of a cell membrane by an oil drop

1967 ◽  
Vol 17 (2) ◽  
pp. 246-251 ◽  
Author(s):  
N.L. Gershfeld ◽  
R.J. Good
Keyword(s):  
Cell Membrane ◽  
Line Tension ◽  
A Cell

scholarly journals Biological activity of liposome-encapsulated murine interferon gamma is mediated by a cell membrane receptor.

1985 ◽  
Vol 82 (11) ◽  
pp. 3688-3692 ◽  
Author(s):  
D. A. Eppstein ◽  
Y. V. Marsh ◽  
M. van der Pas ◽  
P. L. Felgner ◽  
A. B. Schreiber
Keyword(s):  
Biological Activity ◽  
Cell Membrane ◽  
Interferon Gamma ◽  
Membrane Receptor ◽  
A Cell

Non-contact-based determination of membrane permeability to water and dimethyl sulfoxide of cells virtually trapped in a self-induced micro-vortex

Lab on a Chip ◽  
2021 ◽  
Author(s):  
Hsiu-Yang Tseng ◽  
Chiu-Jen Chen ◽  
Zong-Lin Wu ◽  
Yong-Ming Ye ◽  
Guo-Zhen Huang
Keyword(s):  
Cell Membrane ◽  
Dimethyl Sulfoxide ◽  
Membrane Permeability ◽  
Cell Membrane Permeability ◽  
Cell Type ◽  
Cryoprotective Agents ◽  
A Cell

Cell-membrane permeability to water (Lp) and cryoprotective agents (Ps) of a cell type is a crucial cellular information for achieving optimal cryopreservation in the biobanking industry. In this work, a...

GAG Multivalent Systems to interact with Langerin

2021 ◽  
Vol 28 ◽  
Author(s):  
Javier Rojo ◽  
Pedro M. Nieto ◽  
José Luis de Paz
Keyword(s):  
Extracellular Matrix ◽  
Cell Membrane ◽  
Langerhans Cells ◽  
Pivotal Role ◽  
Monomeric Form ◽  
Recognition Sites ◽  
Interaction Processes ◽  
Carbohydrate Ligands ◽  
The Way

: Langerin is a C-type Lectin expressed at the surface of Langerhans cells, which play a pivotal role in protecting organisms against pathogen infections. To address this aim, Langerin presents at least two recognition sites, one Ca2+-dependent and another one independent, capable of recognizing a variety of carbohydrate ligands. In contrast to other lectins, Langerin recognizes sulfated glycosaminoglycans (GAGs), a family of complex and heterogeneous polysaccharides present in the cell membrane and the extracellular matrix at the interphase generated in the trimeric form of Langerin but absent in the monomeric form. The complexity of these oligosaccharides has impeded the development of well-defined monodisperse structures to study these interaction processes. However, in the last few decades, an improvement of synthetic developments to achieve the preparation of carbohydrate multivalent systems mimicking the GAGs has been described. Despite all these contributions, very few examples are reported where the GAG multivalent structures are used to evaluate the interaction with Langerin. These molecules should pave the way to explore these GAG-Langerin interactions.

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