Transient Pore Dynamics in pH-Responsive Liquid Membrane

According to the differences of microenvironments between tumors and healthy tissues, if the anticancer drugs or magnetic resonance contrast agents (MRCAs) can be controlled to precisely match physiological needs at targeted tumor sites, it is expected to acquire better therapeutic efficacy and more accurate diagnosis. Over the decade, stimuli-responsive nanomaterials have been a research hotspot for cancer treatment and diagnosis because they show many excellent functions, such as in vivo imaging, combined targeting drug delivery and systemic controlled release, extended circulation time, etc. Among the various stimuli nanosystems, pH-stimuli mode is regarded as the most general strategy because of solid tumors acidosis. When exposed to weakly acidic tumor microenvironment, pH-responsive nanoplatforms can generate physicochemical changes for their structure and surface characteristics, causing drug release or contrast enhancement. In this review, we focused on the designs of various pH-responsive nanoplatforms and discussed the mechanisms of controlled drug release or switch on-off in MRCAs. This review also discussed the efficacy of cellular internalization for these nanoplatforms via endocytosis of acidic tumor cell. Meanwhile, nanoplatforms response to acidic intracellular pH (such as endosome, lysosome) are discussed, along with approaches for improving drug release performance and magnetic resonance contrast enhancement. A greater understanding of these pH-responsive nanoplatforms will help design more efficient nanomedicine to address the challenges encountered in conventional diagnosis and chemotherapy.

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Polymeric Liquid Membrane Electrodes Incorporated with Macrocyclic Hexaamines for Screening Adenine Nucleotides

Combinatorial Chemistry & High Throughput Screening ◽

10.2174/1386207003331436 ◽

2000 ◽

Vol 3 (6) ◽

pp. 509-517 ◽

Cited By ~ 6

Author(s):

Iwona Szymanska ◽

Hanna Radecka ◽

Jerzy Radecki ◽

Marek Pietraszkiewicz ◽

Oksana Pietraszkiewicz

Keyword(s):

Liquid Membrane ◽

Adenine Nucleotides ◽

Membrane Electrodes ◽

Polymeric Liquid

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Potentiometric Discrimination of Neutral Forms of Nitrophenol Isomers by Liquid Membrane Electrodes Incorporated with Corroles

Combinatorial Chemistry & High Throughput Screening ◽

10.2174/1386207043328724 ◽

2004 ◽

Vol 7 (4) ◽

pp. 375-381 ◽

Cited By ~ 14

Author(s):

Jerzy Radecki ◽

Iwona Stenka ◽

Eddy Dolusic ◽

Wim Dehaen ◽

Janez Plavec

Keyword(s):

Liquid Membrane ◽

Membrane Electrodes

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In Vitro Evaluation of pH Responsive Doxazosin Loaded Mesoporous Silica Nanoparticles: A Smart Approach in Drug Delivery

Current Drug Delivery ◽

10.2174/1567201812666150722123704 ◽

2016 ◽

Vol 13 (4) ◽

pp. 574-581 ◽

Cited By ~ 3

Author(s):

Arijit Guha ◽

Nikhil Biswas ◽

Kaustav Bhattacharjee ◽

Piu Das ◽

Ketousetuo Kuotsu

Keyword(s):

Drug Delivery ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Ph Responsive ◽

In Vitro Evaluation

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Ion selective picrate electrode with liquid membrane

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19793644 ◽

1979 ◽

Vol 44 (12) ◽

pp. 3644-3648 ◽

Cited By ~ 5

Author(s):

Daniel Homolka

Keyword(s):

Vinyl Chloride ◽

Liquid Membrane ◽

Ion Exchanger ◽

Poly Vinyl Chloride ◽

Chloride Matrix

An ion selective picrate electrode with a liquid membrane supported by a poly(vinyl chloride) matrix was proposed. Cetyltrimethylammonium cations in n-hexyl-o-nitrophenyl ether serve as an ion exchanger. The electrode is suitable for analytical purposes.

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