Biomimetic Droplets for Artificial Engagement of Living Cell Surface Receptors: The Specific Case of the T-Cell

Langmuir ◽  
2012 ◽  
Vol 28 (14) ◽  
pp. 6106-6113 ◽  
Author(s):  
Nadia Bourouina ◽  
Julien Husson ◽  
Claire Hivroz ◽  
Nelly Henry
Keyword(s):  
T Cell ◽  
Cell Surface ◽  
Living Cell ◽  
Cell Surface Receptors ◽  
Surface Receptors

scholarly journals Polymyositis, Topological Proteomics Technology and Paradigm for Cell Invasion Dynamics

2002 ◽  
Vol 4 (1) ◽  
pp. 75-84 ◽  
Author(s):  
Walter Schubert
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cell Surface ◽  
Cell Invasion ◽  
Large Scale ◽  
Expression Patterns ◽  
Inflammatory Myopathy ◽  
Protein Profiling ◽  
Cell Surface Receptors ◽  
Surface Receptors

Polymyositis is an inflammatory myopathy characterized by muscle invasion of T-cells penetrating the basal lamina and displacing the plasma membrane of normal muscle fibers. This investigation presents a technology for the direct mapping of protein networks involved in T-cell invasionin situ. Simultaneous localization of 17 adhesive cell surface receptors reveals 18 different combinatorial expression patterns (CEP), which are unique for the T-cell invasion process in muscle tissue. Each invasion step can be assigned to specific CEP on the surface of individual T-cells. This indicates, that the T-cell invasion is enciphered combinatorially in the T-cells' adhesive cell surface proteome fraction. Given 217possible combinations, the T-cell appears to have at its disposal a highly non-random restricted repertoire to specify migratory pathways at the cell surface. These higher-level order functions in the cellular proteome cannot be detected by large-scale protein profiling techniques from tissue homogenates. High-throughput whole cell mapping machines working on structurally intact tissues, as shown here, will allow to measure how cells of different origin (immune cells, tumor cells) combine cell surface receptors to encipher specificity and selectivity for interactions.

Lymphocyte Surface Receptors in Childhood Acute Lymphocytic Leukemia

PEDIATRICS ◽  
1975 ◽  
Vol 56 (5) ◽  
pp. 788-792
Author(s):  
Elaine Esber ◽  
William DiNicola ◽  
Nasser Movassaghi ◽  
Sanford Leikin
Keyword(s):  
Bone Marrow ◽  
T Cell ◽  
Cell Surface ◽  
Peripheral Blood ◽  
Acute Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
The Other ◽  
Cell Surface Receptors ◽  
Surface Receptors ◽  
Lymphocyte Surface

B and T cell lymphocyte surface receptors were studied in the bone marrow and peripheral blood of 16 patients with childhood acute lymphocytic leukemia. T cell surface receptors were identified on the blasts of one patient. Increased percentages of T or B cell surface receptors were not found in the bone marrow of the other 15 patients. There was a negative correlation between the percentage of pathologic cells in the peripheral blood and the percentage of cells with T and B surface receptors. The results of this study indicate that childhood acute lymphocytic leukemia is a heterogeneous disease in terms of lymphcyte surface receptors and that the pathologic cells of the majority of patients with this disease cannot be identified as being of thymic or non-thymic origin.

Mechanistic Implications of the Findings That Opiates and Other Drugs of Abuse Moderate T-Cell Surface Receptors and Antigenic Markers

1987 ◽  
Vol 496 (1 Neuroimmune I) ◽  
pp. 711-721 ◽  
Author(s):  
ROBERT M. DONAHOE ◽  
C. BUESO-RAMOS ◽  
FELICIA DONAHOE ◽  
J. J. MADDEN ◽  
ARTHUR FALEK ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Surface ◽  
Drugs Of Abuse ◽  
Cell Surface Receptors ◽  
Surface Receptors

scholarly journals A Human Leukemia Cell with Both B and T Cell Surface Receptors

1974 ◽  
Vol 71 (3) ◽  
pp. 863-866 ◽  
Author(s):  
E. Shevach ◽  
R. Edelson ◽  
M. Frank ◽  
M. Lutzner ◽  
I. Green
Keyword(s):  
T Cell ◽  
Cell Surface ◽  
Leukemia Cell ◽  
Cell Surface Receptors ◽  
Human Leukemia ◽  
Surface Receptors ◽  
Human Leukemia Cell

scholarly journals Tyrosine phosphorylation of CD6 by stimulation of CD3: augmentation by the CD4 and CD2 coreceptors.

1993 ◽  
Vol 177 (1) ◽  
pp. 219-223 ◽  
Author(s):  
S Wee ◽  
G L Schieven ◽  
J M Kirihara ◽  
T T Tsu ◽  
J A Ledbetter ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cell Surface ◽  
T Cell Activation ◽  
Intracellular Signaling ◽  
Cell Activation ◽  
Cell Receptor ◽  
Surface Proteins ◽  
Cell Surface Receptors ◽  
Surface Receptors

When T cells are activated via the T cell receptor (TCR) complex a number of cellular substrates, including some cell surface proteins, become phosphorylated on tyrosine (Tyr) residues. Phosphorylation of cytoplasmic Tyr renders these cell surface receptors competent to interact with proteins that link cell surface receptors to protein in the intracellular signaling pathways. Here we show that Tyr residues in the cytoplasmic domain of CD6 become phosphorylated upon T cell activation via the TCR complex. Tyr phosphorylation was observed when the T cells were activated by crosslinking CD3 or by cocrosslinking CD3 with CD2 or CD4, but not when the cells were stimulated by crosslinking CD2, CD4, or CD28 alone. Unlike other Tyr kinase substrates, such as the phospholipase C gamma 1-associated pp35/36 protein, whose level of Tyr phosphorylation is highest when T cells are activated by cocrosslinking CD3 with CD2, the levels of CD6 Tyr phosphorylation are highest when T cells were activated by cocrosslinking CD3 with CD4.

scholarly journals Both Extracellular Immunoglobin-like Domains of CD80 Contain Residues Critical for Binding T Cell Surface Receptors CTLA-4 and CD28

1995 ◽  
Vol 270 (36) ◽  
pp. 21181-21187 ◽  
Author(s):  
Robert J. Peach ◽  
Jürgen Bajorath ◽  
Joseph Naemura ◽  
Gina Leytze ◽  
JoAnne Greene ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Surface ◽  
Cell Surface Receptors ◽  
Surface Receptors
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