Poly(lactide-co-glycolide)–Laponite–F68 Nanocomposite Vesicles through a Single-Step Double-Emulsion Method for the Controlled Release of Doxorubicin

Langmuir ◽  
2012 ◽  
Vol 28 (9) ◽  
pp. 4559-4564 ◽  
Author(s):  
Bindu P. Nair ◽  
Chandra P. Sharma
Keyword(s):  
Controlled Release ◽  
Double Emulsion ◽  
Single Step ◽  
Emulsion Method

Facile preparation of PLGA microspheres with diverse internal structures by modified double-emulsion method for controlled release

2014 ◽  
Vol 55 (4) ◽  
pp. 896-906 ◽  
Author(s):  
Fengxuan Han ◽  
Fang Zhou ◽  
Xiaoling Yang ◽  
Jin Zhao ◽  
Yunhui Zhao ◽  
...  
Keyword(s):  
Controlled Release ◽  
Double Emulsion ◽  
Plga Microspheres ◽  
Emulsion Method ◽  
Internal Structures ◽  
Facile Preparation

scholarly journals PREPARATION, CHARACTERIZATION AND EVALUATION OF POLY (LACTIDE –CO –GLYCOLIDE) MICROSPHERES FOR THE CONTROLLED RELEASE OF ZIDOVUDINE

2017 ◽  
Vol 9 (12) ◽  
pp. 70 ◽  
Author(s):  
Seema Kohli ◽  
Abhisek Pal ◽  
Suchit Jain
Keyword(s):  
Particle Size ◽  
Controlled Release ◽  
Double Emulsion ◽  
Entrapment Efficiency ◽  
Diffusion Method ◽  
Average Particle ◽  
Plga Microspheres ◽  
Good Reproducibility ◽  
Solvent Diffusion ◽  
Emulsion Solvent Diffusion Method

Objective: The purpose of this research work was to develop and evaluate microspheres appropriate for controlled release of zidovudine (AZT).Methods: The AZT loaded polylactide-co-glycolide (PLGA) microspheres were prepared by W/O/O double emulsion solvent diffusion method. Compatibility of drug and polymer was studied by Fourier-transform infrared spectroscopy (FTIR). The influence of formulation factors (drug: polymer ratio, stirring speed, the concentration of surfactant) on particle size encapsulation efficiency and in vitro release characteristics of the microspheres was investigated. Release kinetics was studied and stability study was performed as per ICH guidelines.Results: Scanning electron microscopy (SEM) images show good reproducibility of microspheres from different batches. The average particle size was in the range of 216-306 μm. The drug-loaded microspheres showed 74.42±5.08% entrapment efficiency. The cumulative percentage released in phosphate Buffer solution (PBS) buffer was found to be 55.32±5.89 to 74.42±5.08 %. The highest regressions (0.981) were obtained for zero order kinetics followed by Higuchi (0.968) and first order (0.803).Conclusion: Microsphere prepared by double emulsion solvent diffusion method was investigated and the results revealed that 216-306 μm microsphere was successfully encapsulated in a polymer. FT-IR analysis, entrapment efficiency and SEM Studies revealed the good reproducibility from batch to batch. The microspheres were of an appropriate size and suitable for oral administration. Thus the current investigation show promising results of PLGA microspheres as a matrix for drug delivery and merit for In vivo studies for scale up the technology.

scholarly journals Fabrication of PLA-PEG Nanoparticles as Delivery Systems for Improved Stability and Controlled Release of Catechin

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Neha Atulkumar Singh ◽  
Abul Kalam Azad Mandal ◽  
Zaved Ahmed Khan
Keyword(s):  
Controlled Release ◽  
Delivery System ◽  
Oral Delivery ◽  
Polymeric Nanoparticles ◽  
Double Emulsion ◽  
Hydrodynamic Diameter ◽  
Sem Image ◽  
Oral Delivery System ◽  
Improved Stability

The purpose of this study was to develop an oral delivery system for the controlled release of catechin and evaluate the antioxidant potential and stability of catechin loaded PLA/PEG nanoparticles (CATNP). Nanoparticles were synthesized using a double emulsion solvent evaporation method. The fabricated nanoparticles were relatively small with a hydrodynamic diameter of 300 nm and an encapsulation efficiency of 95%. SEM image analysis showed uniform sized and spherically shaped nanoparticles. In vitro release profiles indicated a slow and sustained release of catechin from the nanoparticle. Stability of the nanoparticle in simulated gastric and intestinal fluids is maintained due to the PEG coating on the nanoparticles, which effectively protected catechin against gastrointestinal enzyme activity. Enhanced inhibition action of free radicals and metal chelation potential was noted when catechin was encapsulated in these polymeric nanoparticles. The reports obtained from this study would provide an opportunity for designing an oral delivery system aimed at inhibiting oxidative stress in the human body.

scholarly journals Use of Multi-Hollow Polyester Particles as Opacifying Agent for Injection-Molded Polyethylene

Polymers ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1331
Author(s):  
João F. A. Silva ◽  
Tânia M. T. Carvalho ◽  
Margarida L. Almeida ◽  
Paula Pereira ◽  
Helena Sousa ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Double Emulsion ◽  
Single Step ◽  
Melt Processing ◽  
Light Refraction ◽  
White Pigment ◽  
Titanium Dioxide Content ◽  
Similar Strategy ◽  
Emulsion Process ◽  
Injection Molded

Titanium dioxide is considered the most efficient white pigment for opacification of thermoplastics. However, its high cost, combined with strong price oscillations due to production bottlenecks, has been driving the industry towards alternatives that might allow reducing the titanium dioxide content, while maintaining the product’s opacity. A strategy commonly used in waterborne paints consists in adding hollow polymer particles to the formulation, therefore achieving opacification due to light refraction at the air/polymer interface. In the current work, we show preliminary results that indicate that a similar strategy can be followed for thermoplastics opacification, as long as thermoset particles are used, in order to ensure preservation of the hollow geometry during melt-processing. Multi-vesiculated crosslinked styrene–polyester particles, produced by a single-step double emulsion process, are used. Evidence of synergic interaction between the multi-hollow particles and titanium dioxide has been found.

Modification of PDMS to fabricate PLGA microparticles by a double emulsion method in a single microfluidic device

Lab on a Chip ◽  
2016 ◽  
Vol 16 (14) ◽  
pp. 2596-2600 ◽  
Author(s):  
Leila Montazeri ◽  
Shahin Bonakdar ◽  
Mojtaba Taghipour ◽  
Philippe Renaud ◽  
Hossein Baharvand
Keyword(s):  
Microfluidic Device ◽  
Double Emulsion ◽  
Emulsion Method ◽  
Plga Microparticles

We present an easy, durable method to generate a partially hydrophilic/hydrophobic poly(dimethylsiloxane) (PDMS) microfluidic device.

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