Magnetic Nanocarriers of Doxorubicin Coated with Poly(ethylene glycol) and Folic Acid: Relation between Coating Structure, Surface Properties, Colloidal Stability, and Cancer Cell Targeting

Langmuir ◽  
2011 ◽  
Vol 28 (2) ◽  
pp. 1496-1505 ◽  
Author(s):  
Karine Kaaki ◽  
Katel Hervé-Aubert ◽  
Manuela Chiper ◽  
Andriy Shkilnyy ◽  
Martin Soucé ◽  
...  
Keyword(s):  
Folic Acid ◽  
Ethylene Glycol ◽  
Surface Properties ◽  
Colloidal Stability ◽  
Poly Ethylene Glycol ◽  
Coating Structure ◽  
Structure Surface ◽  
Cancer Cell Targeting ◽  
Poly Ethylene ◽  
Magnetic Nanocarriers

A smart drug-delivery nanosystem based on carboxylated graphene quantum dots for tumor-targeted chemotherapy

Nanomedicine ◽  
2019 ◽  
Vol 14 (15) ◽  
pp. 2011-2025 ◽  
Author(s):  
Zhen Li ◽  
Jialong Fan ◽  
Chunyi Tong ◽  
Hongyan Zhou ◽  
Wenmiao Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Quantum Dots ◽  
Folic Acid ◽  
Ethylene Glycol ◽  
Drug Delivery System ◽  
Delivery System ◽  
Graphene Quantum Dots ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Aim: Constructing a new drug-delivery system using carboxylated graphene quantum dots (cGQDs) for tumor chemotherapy in vivo. Materials & methods: A drug-delivery system was synthesized through a crosslink reaction of cGQDs, NH2-poly(ethylene glycol)-NH2 and folic acid. Results: A drug delivery system of folic acid-poly(ethylene glycol)-cGQDs was successfully constructed with ideal entrapment efficiency (97.5%) and drug-loading capacity (40.1%). Cell image indicated that the nanosystem entered into human cervical cancer cells mainly through macropinocytosis-dependent pathway. In vivo experiments showed the outstanding antitumor ability and low systemic toxicity of this nanodrug-delivery system. Conclusion: The newly developed drug-delivery system provides an important alternative for tumor therapy without causing systemic adverse effects.

Specific Antitumor Targetable β-Cyclodextrin−Poly(ethylene Glycol)−Folic Acid Drug Delivery Bioconjugate

2004 ◽  
Vol 15 (5) ◽  
pp. 997-1004 ◽  
Author(s):  
Stefano Salmaso ◽  
Alessandra Semenzato ◽  
Paolo Caliceti ◽  
Johan Hoebeke ◽  
Fabio Sonvico ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Multidentate Poly(ethylene glycol) Ligands Provide Colloidal Stability to Semiconductor and Metallic Nanocrystals in Extreme Conditions

2010 ◽  
Vol 132 (28) ◽  
pp. 9804-9813 ◽  
Author(s):  
Michael H. Stewart ◽  
Kimihiro Susumu ◽  
Bing C. Mei ◽  
Igor L. Medintz ◽  
James B. Delehanty ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Colloidal Stability ◽  
Extreme Conditions ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene
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