Bioadhesive Control of Plasma Proteins and Blood Cells from Umbilical Cord Blood onto the Interface Grafted with Zwitterionic Polymer Brushes

Langmuir ◽  
2012 ◽  
Vol 28 (9) ◽  
pp. 4309-4317 ◽  
Author(s):  
Yu Chang ◽  
Yung Chang ◽  
Akon Higuchi ◽  
Yu-Ju Shih ◽  
Pei-Tsz Li ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Blood Cells ◽  
Polymer Brushes ◽  
Plasma Proteins ◽  
Zwitterionic Polymer

Long-term engraftment stability of umbilical cord blood cells preserved in −135 °C mechanical freezers

2021 ◽  
pp. 106590
Author(s):  
Harumi Kato ◽  
Hirofumi Taji ◽  
Takeshi Kodaira ◽  
Tomohiro Kinoshita ◽  
Kazuhito Yamamoto
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Blood Cells ◽  
Cord Blood Cells ◽  
Umbilical Cord Blood Cells

scholarly journals Human Leukocyte Antigen and Red Blood Cells Impact Umbilical Cord Blood CD34+ Cell Viability after Thawing

2019 ◽  
Vol 20 (19) ◽  
pp. 4875 ◽  
Author(s):  
Vanegas ◽  
Galindo ◽  
Páez-Gutiérrez ◽  
González-Acero ◽  
Medina-Valderrama ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Cell Viability ◽  
Cord Blood ◽  
Red Blood Cells ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Blood Cells ◽  
Human Leukocyte ◽  
Hla Typing ◽  
Leukocyte Antigen

Hematopoietic progenitor cell (HPC) transplantation is a treatment option for malignant and nonmalignant diseases. Umbilical cord blood (UCB) is an important HPC source, mainly for pediatric patients. It has been demonstrated that human leukocyte antigen (HLA) matching and cell dose are the most important features impacting clinical outcomes. However, UCB matching is performed using low resolution HLA typing and it has been demonstrated that the unnoticed mismatches negatively impact the transplant. Since we found differences in CD34+ viability after thawing of UCB units matched for two different patients (p = 0.05), we presumed a possible association between CD34+ cell viability and HLA. We performed a multivariate linear model (n = 67), comprising pre-cryopreservation variables and high resolution HLA genotypes separately. We found that pre-cryopreservation red blood cells (RBC), granulocytes, and viable CD34+ cell count significantly impacted CD34+ viability after thawing, along with HLA-B or -C (R2 = 0.95, p = 0.01; R2 = 0.56, p = 0.007, respectively). Although HLA-B*40:02 may have a negative impact on CD34+ cell viability, RBC depletion significantly improves it.

In vitro clinical-grade generation of red blood cells from human umbilical cord blood CD34+ cells

Transfusion ◽  
2008 ◽  
Vol 48 (10) ◽  
pp. 2235-2245 ◽  
Author(s):  
Eun Jung Baek ◽  
Han-Soo Kim ◽  
Sinyoung Kim ◽  
Honglien Jin ◽  
Tae-Yeal Choi ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Blood Cells ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord ◽  
Clinical Grade ◽  
Cd34 Cells ◽  
Cord Blood Cd34

Hepatocyte differentiation from embryonic stem cells and umbilical cord blood cells

2005 ◽  
Vol 12 (3) ◽  
pp. 196-202 ◽  
Author(s):  
Kenichi Teramoto ◽  
Kinji Asahina ◽  
Yuji Kumashiro ◽  
Sei Kakinuma ◽  
Ryoko Chinzei ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Blood Cells ◽  
Embryonic Stem ◽  
Hepatocyte Differentiation ◽  
Cord Blood Cells ◽  
Umbilical Cord Blood Cells

scholarly journals Noninvasive Bioluminescent Imaging Demonstrates Long-Term Multilineage Engraftment of Ex Vivo-Expanded CD34-Selected Umbilical Cord Blood Cells

Stem Cells ◽  
2009 ◽  
Vol 27 (8) ◽  
pp. 1932-1940 ◽  
Author(s):  
David Steiner ◽  
Juri Gelovani ◽  
Barbara Savoldo ◽  
Simon N. Robinson ◽  
William K. Decker ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Blood Cells ◽  
Ex Vivo ◽  
Bioluminescent Imaging ◽  
Cord Blood Cells ◽  
Umbilical Cord Blood Cells

Applications of Human Umbilical Cord Blood Cells in Central Nervous System Regeneration

2010 ◽  
Vol 5 (1) ◽  
pp. 17-22 ◽  
Author(s):  
Antonio Herranz ◽  
Rafael Gonzalo-Gobernado ◽  
Diana Reimers ◽  
Maria Asensio ◽  
Macarena Rodriguez-Serrano ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Blood Cells ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord ◽  
Cord Blood Cells ◽  
Umbilical Cord Blood Cells
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