scholarly journals Simple Method for Preparing Poly(ethylene glycol)-Surface-Conjugated Liposome-Encapsulated Hemoglobins: Physicochemical Properties, Long-Term Storage Stability, and Their Reactions with O2, CO, and NO

Langmuir ◽  
2011 ◽  
Vol 27 (14) ◽  
pp. 8829-8840 ◽  
Author(s):  
Shahid Rameez ◽  
Andre F. Palmer
Keyword(s):  
Ethylene Glycol ◽  
Physicochemical Properties ◽  
Storage Stability ◽  
Poly Ethylene Glycol ◽  
Simple Method ◽  
Long Term Storage ◽  
Poly Ethylene ◽  
Term Storage

scholarly journals Poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) Copolymers for the Formulation of In Situ Forming Depot Long-Acting Injectables

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 605
Author(s):  
Marie-Emérentienne Cagnon ◽  
Silvio Curia ◽  
Juliette Serindoux ◽  
Jean-Manuel Cros ◽  
Feifei Ng ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Surface Erosion ◽  
Sustained Delivery ◽  
Trimethylene Carbonate ◽  
Poly Ethylene Glycol ◽  
In Situ Forming ◽  
Poly Ethylene ◽  
Long Acting

This article describes the utilization of (methoxy)poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) ((m)PEG–PTMC) diblock and triblock copolymers for the formulation of in situ forming depot long-acting injectables by solvent exchange. The results shown in this manuscript demonstrate that it is possible to achieve long-term drug deliveries from suspension formulations prepared with these copolymers, with release durations up to several months in vitro. The utilization of copolymers with different PEG and PTMC molecular weights affords to modulate the release profile and duration. A pharmacokinetic study in rats with meloxicam confirmed the feasibility of achieving at least 28 days of sustained delivery by using this technology while showing good local tolerability in the subcutaneous environment. The characterization of the depots at the end of the in vivo study suggests that the rapid phase exchange upon administration and the surface erosion of the resulting depots are driving the delivery kinetics from suspension formulations. Due to the widely accepted utilization of meloxicam as an analgesic drug for animal care, the results shown in this article are of special interest for the development of veterinary products aiming at a very long-term sustained delivery of this therapeutic molecule.

scholarly journals Evaluation of the Long-Term Storage Stability of the Cyanide Antidote: Dimethyl Trisulfide and Degradation Product Identification

ACS Omega ◽  
2020 ◽  
Vol 5 (42) ◽  
pp. 27171-27179 ◽  
Author(s):  
Indika K. Warnakula ◽  
Afshin Ebrahimpour ◽  
Sun Yi Li ◽  
Ramesha D. Gaspe Ralalage ◽  
Chathuranga C. Hewa-Rahinduwage ◽  
...  
Keyword(s):  
Degradation Product ◽  
Storage Stability ◽  
Dimethyl Trisulfide ◽  
Long Term Storage ◽  
Cyanide Antidote ◽  
Product Identification ◽  
Term Storage

Poly(ethylene glycol)-Conjugation and Deoxygenation Enable Long-Term Preservation of Hemoglobin-Vesicles as Oxygen Carriers in a Liquid State

2000 ◽  
Vol 11 (3) ◽  
pp. 425-432 ◽  
Author(s):  
Hiromi Sakai ◽  
Ken-ichi Tomiyama ◽  
Keitaro Sou ◽  
Shinji Takeoka ◽  
Eishun Tsuchida
Keyword(s):  
Ethylene Glycol ◽  
Liquid State ◽  
Oxygen Carriers ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Long Term Preservation

Retrospective statistical analysis of lyophilized protein formulations of progenipoietin using PLS: Determination of the critical parameters for long-term storage stability

2004 ◽  
Vol 93 (10) ◽  
pp. 2609-2623 ◽  
Author(s):  
Derrick S. Katayama ◽  
Carol F. Kirchhoff ◽  
Carrie M. Elliott ◽  
Robert E. Johnson ◽  
Jeffry Borgmeyer ◽  
...  
Keyword(s):  
Statistical Analysis ◽  
Storage Stability ◽  
Critical Parameters ◽  
Long Term Storage ◽  
Protein Formulations ◽  
Term Storage

scholarly journals Rapid Recovery of Clofazimine-Loaded Nanoparticles with Long-Term Storage Stability as Anti-Cryptosporidium Therapy

2018 ◽  
Vol 1 (5) ◽  
pp. 2184-2194 ◽  
Author(s):  
Jie Feng ◽  
Yingyue Zhang ◽  
Simon A. McManus ◽  
Kurt D. Ristroph ◽  
Hoang D. Lu ◽  
...  
Keyword(s):  
Storage Stability ◽  
Rapid Recovery ◽  
Long Term Storage ◽  
Term Storage

Long term storage stability of bio-oil from rice husk fast pyrolysis

Energy ◽  
2019 ◽  
Vol 186 ◽  
pp. 115882 ◽  
Author(s):  
Wenfei Cai ◽  
Ning Kang ◽  
Moon Ki Jang ◽  
Chen Sun ◽  
Ronghou Liu ◽  
...  
Keyword(s):  
Rice Husk ◽  
Storage Stability ◽  
Fast Pyrolysis ◽  
Long Term Storage ◽  
Bio Oil ◽  
Term Storage

Long-Term Storage Stability of the Bacteriocin Propionicin PLG-1 Produced by Propionibacterium thoenii and Potential as a Food Preservative†

1996 ◽  
Vol 59 (5) ◽  
pp. 481-486 ◽  
Author(s):  
HSING-YI HSIEH ◽  
BONITA A. GLATZ
Keyword(s):  
Storage Stability ◽  
Skim Milk ◽  
Lactobacillus Delbrueckii ◽  
Food Preservative ◽  
Long Term Storage ◽  
Cell Counts ◽  
Viable Cells ◽  
Propionibacterium Thoenii ◽  
Term Storage

Propionicin PLG-1, a bacteriocin produced by Propionibacterium thoenii strain P127, was tested for characteristics that could determine its usefulness as a food preservative: long-term storage stability and effectiveness in a food model system. Partially purified propionicin PLG-1 samples, lyophilized and nonlyophilized, were stored at 25, 4, and −20°C. Bacteriocin activity increased by as much as 200% over the first 10 days of storage in nonlyophilized samples stored at 25 or 4°C. Activity then decreased gradually for samples stored at 25°C while samples stored at 4°C retained high activity through 14 weeks of storage. Nonlyophilized samples frozen at −20°C and lyophilized samples stored at all temperatures did not change significantly in activity through 25 weeks of storage. Propionicin was added at 100 and 1,000 arbitrary units (AU)/ml to lactobacilli MRS broth and to skim milk, each inoculated with 105 cells per ml of Lactobacillus delbrueckii ATCC 4797. Upon incubation at 37°C with 1,000 AU/ml, cell numbers were reduced by at least 4 log units within 2 h and no viable cells were detected after 96 h in either medium. With 100 AU/ml of propionicin, viable cells were reduced by 2 log units within 12 h at 37°C, but culture growth resumed after 24 h. At 15°C, no viable cells were detected after 48 h in the presence of 1,000 AU/ml of propionicin, while viable cell counts were gradually reduced to about 10 cells per ml by 168 h in the presence of 100 AU/ml of propionicin.

scholarly journals Insulin/poly(ethylene glycol)-block-poly(l-lysine) Complexes: Physicochemical Properties and Protein Encapsulation

2015 ◽  
Vol 119 (22) ◽  
pp. 6813-6819 ◽  
Author(s):  
Natassa Pippa ◽  
Radostina Kalinova ◽  
Ivaylo Dimitrov ◽  
Stergios Pispas ◽  
Costas Demetzos
Keyword(s):  
Ethylene Glycol ◽  
Physicochemical Properties ◽  
Protein Encapsulation ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene
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