Quick Synthesis of Lipid−Polymer Hybrid Nanoparticles with Low Polydispersity Using a Single-Step Sonication Method

Langmuir ◽  
2010 ◽  
Vol 26 (22) ◽  
pp. 16958-16962 ◽  
Author(s):  
Ronnie H. Fang ◽  
Santosh Aryal ◽  
Che-Ming Jack Hu ◽  
Liangfang Zhang
Keyword(s):  
Single Step ◽  
Hybrid Nanoparticles ◽  
Polymer Hybrid

Single-Step Assembly of Cationic Lipid–Polymer Hybrid Nanoparticles for Systemic Delivery of siRNA

ACS Nano ◽  
2012 ◽  
Vol 6 (6) ◽  
pp. 4955-4965 ◽  
Author(s):  
Xian-Zhu Yang ◽  
Shuang Dou ◽  
Yu-Cai Wang ◽  
Hong-Yan Long ◽  
Meng-Hua Xiong ◽  
...  
Keyword(s):  
Cationic Lipid ◽  
Single Step ◽  
Hybrid Nanoparticles ◽  
Systemic Delivery ◽  
Polymer Hybrid

Development and characterization of single step self-assembled lipid polymer hybrid nanoparticles for effective delivery of methotrexate

RSC Advances ◽  
2015 ◽  
Vol 5 (77) ◽  
pp. 62989-62999 ◽  
Author(s):  
Neeraj K. Garg ◽  
Bhupinder Singh ◽  
Gajanand Sharma ◽  
Varun Kushwah ◽  
Rajeev K. Tyagi ◽  
...  
Keyword(s):  
Single Step ◽  
Controlled Delivery ◽  
Hybrid Nanoparticles ◽  
Polymer Hybrid ◽  
Effective Delivery ◽  
Self Assembled

The present study was designed to develop methotrexate (MTX) loaded lipid polymer hybrid nanoparticles (LPHNPs) for spatial and controlled delivery of this drug.

Lipid-polymer hybrid nanoparticles: Synthesis strategies and biomedical applications

2019 ◽  
Vol 160 ◽  
pp. 130-142 ◽  
Author(s):  
Vivek Dave ◽  
Kajal Tak ◽  
Amit Sohgaura ◽  
Ashish Gupta ◽  
Veera Sadhu ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Hybrid Nanoparticles ◽  
Polymer Hybrid ◽  
Nanoparticles Synthesis

scholarly journals Hybrid Biopolymer and Lipid Nanoparticles with Improved Transfection Efficacy for mRNA

Cells ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 2034 ◽  
Author(s):  
Christian D. Siewert ◽  
Heinrich Haas ◽  
Vera Cornet ◽  
Sara S. Nogueira ◽  
Thomas Nawroth ◽  
...  
Keyword(s):  
Small Angle ◽  
Messenger Rna ◽  
Physicochemical Characterization ◽  
Single Step ◽  
Model Systems ◽  
Molecular Organization ◽  
Hybrid Nanoparticles ◽  
Polymer Mixture ◽  
Internal Organization ◽  
Transfection Efficacy

Hybrid nanoparticles from lipidic and polymeric components were assembled to serve as vehicles for the transfection of messenger RNA (mRNA) using different portions of the cationic lipid DOTAP (1,2-Dioleoyl-3-trimethylammonium-propane) and the cationic biopolymer protamine as model systems. Two different sequential assembly approaches in comparison with a direct single-step protocol were applied, and molecular organization in correlation with biological activity of the resulting nanoparticle systems was investigated. Differences in the structure of the nanoparticles were revealed by thorough physicochemical characterization including small angle neutron scattering (SANS), small angle X-ray scattering (SAXS), and cryogenic transmission electron microscopy (cryo-TEM). All hybrid systems, combining lipid and polymer, displayed significantly increased transfection in comparison to lipid/mRNA and polymer/mRNA particles alone. For the hybrid nanoparticles, characteristic differences regarding the internal organization, release characteristics, and activity were determined depending on the assembly route. The systems with the highest transfection efficacy were characterized by a heterogenous internal organization, accompanied by facilitated release. Such a system could be best obtained by the single step protocol, starting with a lipid and polymer mixture for nanoparticle formation.

Photoresponsive lipid-polymer hybrid nanoparticles for controlled doxorubicin release

2017 ◽  
Vol 28 (25) ◽  
pp. 255101 ◽  
Author(s):  
Cuiping Yao ◽  
Ming Wu ◽  
Cecheng Zhang ◽  
Xinyi Lin ◽  
Zuwu Wei ◽  
...  
Keyword(s):  
Hybrid Nanoparticles ◽  
Polymer Hybrid ◽  
Doxorubicin Release

scholarly journals Lipid-polymer hybrid nanoparticles: Development & statistical optimization of norfloxacin for topical drug delivery system

2017 ◽  
Vol 2 (4) ◽  
pp. 269-280 ◽  
Author(s):  
Vivek Dave ◽  
Renu Bala Yadav ◽  
Kriti Kushwaha ◽  
Sachdev Yadav ◽  
Swapnil Sharma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Statistical Optimization ◽  
Hybrid Nanoparticles ◽  
Topical Drug Delivery ◽  
Polymer Hybrid

Pulmonary delivery of antitubercular drugs using spray-dried lipid–polymer hybrid nanoparticles

2015 ◽  
Vol 44 (6) ◽  
pp. 1544-1555 ◽  
Author(s):  
Ankur Bhardwaj ◽  
Shuchi Mehta ◽  
Shailendra Yadav ◽  
Sudheer K. Singh ◽  
Anne Grobler ◽  
...  
Keyword(s):  
Pulmonary Delivery ◽  
Hybrid Nanoparticles ◽  
Antitubercular Drugs ◽  
Polymer Hybrid ◽  
Spray Dried
Sign in / Sign up

Export Citation Format

Share Document