Polymerization-like Multilevel Hierarchical Self-Assembly of Polymer Vesicles into Macroscopic Superstructures with Controlled Complexity

Langmuir ◽  
2010 ◽  
Vol 26 (18) ◽  
pp. 14512-14519 ◽  
Author(s):  
Haibao Jin ◽  
Yongfeng Zhou ◽  
Wei Huang ◽  
Deyue Yan
Keyword(s):  
Self Assembly ◽  
Polymer Vesicles

Flow Chemistry Controls Both Self-Assembly and the Entrapped Oscillatory Cargo in Belousov-Zhabotinsky Driven Polymerization-Induced Self-Assembly

2019 ◽  
Author(s):  
Liman Hou ◽  
Marta Dueñas-Diez ◽  
Rohit Srivastava ◽  
Juan Perez-Mercader
Keyword(s):  
Self Assembly ◽  
Flow Chemistry ◽  
Batch Reactors ◽  
Equilibrium Conditions ◽  
One Pot ◽  
Bz Reaction ◽  
Polymer Vesicles ◽  
Simultaneous Control ◽  
Novel Method ◽  
Continuously Stirred Tank Reactor

<p></p><p>Belousov-Zhabotinsky (B-Z) reaction driven polymerization-induced self-assembly (PISA), or B-Z PISA, is a novel method for the autonomous one-pot synthesis of polymer vesicles from a macroCTA (macro chain transfer agent) and monomer solution (“soup”) containing the above and the BZ reaction components. In it, the polymerization is driven (and controlled) by periodically generated radicals generated in the oscillations of the B-Z reaction. These are inhibitor/activator radicals for the polymerization. Until now B-Z PISA has only been carried out in batch reactors. In this manuscript we present the results of running the system using a continuously stirred tank reactor (CSTR) configuration which offers some interesting advantages.Indeed, by controlling the CSTR parameters we achieve reproducible and simultaneous control of the PISA process and of the properties of the oscillatory cargo encapsulated in the resulting vesicles. Furthermore, the use of flow chemistry enables a more precise morphology control and chemical cargo tuning. Finally, in the context of biomimetic applications a CSTR operation mimics more closely the open non-equilibrium conditions of living systems and their surrounding environments.</p><p></p>

On-demand shape transformation of polymer vesicles via site-specific isomerization of hydrazone photoswitches in monodisperse hydrophobic oligomers

2021 ◽  
Author(s):  
Valene Wang ◽  
Jiwon Kim ◽  
Junyoung Kim ◽  
Seul Woo Lee ◽  
Kyoung Taek Kim
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Conformational Change ◽  
Self Assembly ◽  
Shape Control ◽  
Shape Transformation ◽  
Site Specific ◽  
On Demand ◽  
Polymer Vesicles

The shape control of nanostructures formed by the solution self-assembly of block copolymers is of significance for drug delivery. In particular, site-specific perturbation resulting in the conformational change of the...

Hyperbranched polymer vesicles: from self-assembly, characterization, mechanisms, and properties to applications

2015 ◽  
Vol 44 (12) ◽  
pp. 3874-3889 ◽  
Author(s):  
Wenfeng Jiang ◽  
Yongfeng Zhou ◽  
Deyue Yan
Keyword(s):  
Self Assembly ◽  
Hyperbranched Polymer ◽  
Polymer Vesicles

This tutorial review summarizes the first 10 years of work on hyperbranched polymer vesicles from syntheses, self-assembly, and properties to applications.

scholarly journals Confinement of Therapeutic Enzymes in Selectively Permeable Polymer Vesicles by Polymerization-Induced Self-Assembly (PISA) Reduces Antibody Binding and Proteolytic Susceptibility

2018 ◽  
Vol 4 (6) ◽  
pp. 718-723 ◽  
Author(s):  
Lewis D. Blackman ◽  
Spyridon Varlas ◽  
Maria C. Arno ◽  
Zachary H. Houston ◽  
Nicholas L. Fletcher ◽  
...  
Keyword(s):  
Self Assembly ◽  
Antibody Binding ◽  
Polymer Vesicles ◽  
Permeable Polymer ◽  
Therapeutic Enzymes

scholarly journals Tuning Size and Morphology of mPEG-b-p(HPMA-Bz) Copolymer Self-Assemblies Using Microfluidics

Polymers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 2572
Author(s):  
Jaleesa Bresseleers ◽  
Mahsa Bagheri ◽  
Coralie Lebleu ◽  
Sébastien Lecommandoux ◽  
Olivier Sandre ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Self Assembly ◽  
Size Difference ◽  
Flow Rates ◽  
Polymer Vesicles ◽  
Attractive Option ◽  
Self Assembled ◽  
Size And Morphology ◽  
Poly Ethylene ◽  
Careful Design

The careful design of nanoparticles, in terms of size and morphology, is of great importance to developing effective drug delivery systems. The ability to precisely tailor nanoparticles in size and morphology during polymer self-assembly was therefore investigated. Four poly(ethylene glycol)-b-poly(N-2-benzoyloxypropyl methacrylamide) mPEG-b-p(HPMA-Bz) block copolymers with a fixed hydrophilic block of mPEG 5 kDa and a varying molecular weight of the hydrophobic p(HPMA-Bz) block (A: 17.1, B: 10.0, C: 5.2 and D: 2.7 kDa) were self-assembled into nanoparticles by nanoprecipitation under well-defined flow conditions, using microfluidics, at different concentrations. The nanoparticles from polymer A, increased in size from 55 to 90 nm using lower polymer concentrations and slower flow rates and even polymer vesicles were formed along with micelles. Similarly, nanoparticles from polymer D increased in size from 35 to 70 nm at slower flow rates and also formed vesicles along with micelles, regardless of the used concentration. Differently, polymers B and C mainly self-assembled into micelles at the different applied flow rates with negligible size difference. In conclusion, this study demonstrates that the self-assembly of mPEG-b-p(HPMA-Bz) block copolymers can be easily tailored in size and morphology using microfluidics and is therefore an attractive option for further scaled-up production activities.

Self‐Assembly of Giant Polymer Vesicles by Light‐Assisted Solid Hydration

2019 ◽  
Vol 40 (9) ◽  
pp. 1900027 ◽  
Author(s):  
Lucas Caire da Silva ◽  
Emeline Rideau ◽  
Katharina Landfester
Keyword(s):  
Self Assembly ◽  
Polymer Vesicles

Open-air preparation of cross-linked CO2-responsive polymer vesicles by enzyme-assisted photoinitiated polymerization-induced self-assembly

2019 ◽  
Vol 55 (79) ◽  
pp. 11920-11923 ◽  
Author(s):  
Liangliang Yu ◽  
Yuxuan Zhang ◽  
Xiaocong Dai ◽  
Qin Xu ◽  
Li Zhang ◽  
...  
Keyword(s):  
Self Assembly ◽  
High Solids ◽  
Photoinitiated Polymerization ◽  
Polymer Vesicles ◽  
Responsive Polymer

An open-air strategy via enzyme-assisted photoinitiated polymerization-induced self-assembly (photo-PISA) in water is developed for preparing cross-linked CO2-responsive vesicles at high solids contents.

Formation of polymer vesicles by simultaneous chain growth and self-assembly of amphiphilic block copolymers

2009 ◽  
pp. 2887 ◽  
Author(s):  
Guillaume Delaittre ◽  
Charlotte Dire ◽  
Jutta Rieger ◽  
Jean-Luc Putaux ◽  
Bernadette Charleux
Keyword(s):  
Block Copolymers ◽  
Self Assembly ◽  
Amphiphilic Block Copolymers ◽  
Chain Growth ◽  
Polymer Vesicles

Cationic Charged Polymer Vesicles from Amphiphilic PEI-g-PSSA-g-PEI as Potential Gene Delivery Vehicles

2015 ◽  
Vol 68 (5) ◽  
pp. 806 ◽  
Author(s):  
Liandong Feng ◽  
Xinyu Hu ◽  
Aming Xie ◽  
Hao Yu ◽  
Yangyang Liu ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Self Assembly ◽  
Transfection Efficiency ◽  
Hexagonal Structure ◽  
Polymer Vesicles ◽  
Small Series ◽  
Transmission Electron ◽  
Delivery Vehicles ◽  
Insoluble Polymers

Polymer vesicles have attracted extensive interest for a variety of biomedical applications. Herein, novel polymer vesicles are prepared by the self-assembly of amphiphilic polyethyleneimine-g-poly(disulfide amine)-g-polyethyleneimine (PEI-g-PSSA-g-PEI) for gene delivery. To investigate the effect of hydrophobicity on transfection efficiency, a small series of PEI-g-PSSA-g-PEI were prepared under uniform conditions containing PEI fragments of the same molecular weight. The hydrophobicity of PEI-g-PSSA-g-PEI was adjusted by varying the hydrophobic content in the poly(disulfide amine) backbone and by choosing hydrophobic monomers ranging in length from C12 to C16. The hydrophobicity of polymers was also related to DNA binding affinity. Polymer vesicles obtained from the water-insoluble polymers condensed with DNA into polyplexes with sizes below 200 nm and surface charge ranging from +10 to +35 mV that were suitable for cell endocytosis. DNA polyplexes exhibited an inverted hexagonal structure, observed by transmission electron microscopy. The results of in vitro transfection demonstrate that the hydrophobic–hydrophilic balance of copolymers greatly affects their transfection properties. The top-performing polymer, II-70 %, showed improved transfection efficiency and significantly lower cytotoxicity on COS-7 cells when compared with commercial reagents polyethyleneimine (PEI 25K) and Lipofectamine 2000. These results indicate that cationic polymer vesicles with tunable hydrophobicity are promising materials for gene delivery.

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