Hierarchical Self-Assembly of Designed 2 × 2-α-Helix Bundle Proteins on Au(111) Surfaces

Langmuir ◽  
2006 ◽  
Vol 22 (15) ◽  
pp. 6661-6667 ◽  
Author(s):  
Hainer Wackerbarth ◽  
A. Pernille Tofteng ◽  
Knud J. Jensen ◽  
Ib Chorkendorff ◽  
Jens Ulstrup
Keyword(s):  
Self Assembly ◽  
Helix Bundle ◽  
Α Helix

De NovoDesign and Synthesis of Four α-Helix Bundle Proteins with Flavin Function

1993 ◽  
Vol 22 (9) ◽  
pp. 1533-1536 ◽  
Author(s):  
Hisakazu Mihara ◽  
Kin-ya Tomizaki ◽  
Norikazu Nishino ◽  
Tsutomu Fujimoto
Keyword(s):  
Helix Bundle ◽  
Α Helix

Self-Assembly of a Four-Helix Bundle on a DNA Quadruplex

2009 ◽  
Vol 48 (15) ◽  
pp. 2749-2751 ◽  
Author(s):  
Brooke A. Rosenzweig ◽  
Andrew D. Hamilton
Keyword(s):  
Self Assembly ◽  
Helix Bundle ◽  
Dna Quadruplex ◽  
Four Helix Bundle

scholarly journals Tubular Assembly Formation Induced by Leucine Alignment along the Hydrophobic Helix of Amphiphilic Polypeptides

2021 ◽  
Vol 22 (21) ◽  
pp. 12075
Author(s):  
Mohammed A. Abosheasha ◽  
Toru Itagaki ◽  
Yoshihiro Ito ◽  
Motoki Ueda
Keyword(s):  
Double Layer ◽  
Self Assembly ◽  
Helical Structure ◽  
Tube Formation ◽  
Rolled Sheet ◽  
Α Helix ◽  
Necessary And Sufficient ◽  
Hydrophobic Helix ◽  
Nanotube Dispersion ◽  
Spherical Vesicles

The introduction of α-helical structure with a specific helix–helix interaction into an amphipathic molecule enables the determination of the molecular packing in the assembly and the morphological control of peptide assemblies. We previously reported that the amphiphilic polypeptide SL12 with a polysarcosine (PSar) hydrophilic chain and hydrophobic α-helix (l-Leu-Aib)6 involving the LxxxLxxxL sequence, which induces homo-dimerization due to the concave–convex interaction, formed a nanotube with a uniform 80 nm diameter. In this study, we investigated the importance of the LxxxLxxxL sequence for tube formation by comparing amphiphilic polypeptide SL4A4L4 with hydrophobic α-helix (l-Leu-Aib)2-(l-Ala-Aib)2-(l-Leu-Aib)2 and SL12. SL4A4L4 formed spherical vesicles and micelles. The effect of the LxxxLxxxL sequence elongation on tube formation was demonstrated by studying assemblies of PSar-b-(l-Ala-Aib)-(l-Leu-Aib)6-(l-Ala-Aib) (SA2L12A2) and PSar-b-(l-Leu-Aib)8 (SL16). SA2L12A2 formed nanotubes with a uniform 123 nm diameter, while SL16 assembled into vesicles. These results showed that LxxxLxxxL is a necessary and sufficient sequence for the self-assembly of nanotubes. Furthermore, we fabricated a double-layer nanotube by combining two kinds of nanotubes with 80 and 120 nm diameters—SL12 and SA2L12A2. When SA2L12A2 self-assembled in SL12 nanotube dispersion, SA2L12A2 initially formed a rolled sheet, the sheet then wrapped the SL12 nanotube, and a double-layer nanotube was obtained.

scholarly journals Protein Evolution across Fold Classes: A 3-α-Helix Bundle can Switch to β, α/β, and α+β Folds by Stepwise Mutation

2015 ◽  
Vol 108 (2) ◽  
pp. 203a-204a
Author(s):  
Lauren L. Porter ◽  
Yanan He ◽  
Yihong Chen ◽  
John Orban ◽  
Philip N. Bryan
Keyword(s):  
Protein Evolution ◽  
Helix Bundle ◽  
Stepwise Mutation ◽  
Α Helix

scholarly journals Amyloid Self‐Assembly of hIAPP8‐20 via the Accumulation of Helical Oligomers, α‐Helix to β‐Sheet Transition, and Formation of β‐Barrel Intermediates

Small ◽  
2019 ◽  
Vol 15 (18) ◽  
pp. 1805166 ◽  
Author(s):  
Yunxiang Sun ◽  
Aleksandr Kakinen ◽  
Yanting Xing ◽  
Pouya Faridi ◽  
Aparna Nandakumar ◽  
...  
Keyword(s):  
Self Assembly ◽  
Α Helix ◽  
Β Sheet

Self-Assembly of Heme A and Heme B in a Designed Four-Helix Bundle:  Implications for a CytochromecOxidase Maquette†

Biochemistry ◽  
2000 ◽  
Vol 39 (36) ◽  
pp. 11041-11049 ◽  
Author(s):  
Brian R. Gibney ◽  
Yasuhiro Isogai ◽  
Francesc Rabanal ◽  
Konda S. Reddy ◽  
Anne M. Grosset ◽  
...  
Keyword(s):  
Self Assembly ◽  
Helix Bundle ◽  
Four Helix Bundle

Stabilization of an α Helix by β-Sheet-Mediated Self-Assembly of a Macrocyclic Peptide

2009 ◽  
Vol 121 (9) ◽  
pp. 1629-1633 ◽  
Author(s):  
Yong-beom Lim ◽  
Kyung-Soo Moon ◽  
Myongsoo Lee
Keyword(s):  
Self Assembly ◽  
Α Helix ◽  
Β Sheet ◽  
Macrocyclic Peptide
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