Toluene Solubilization Induces Different Modes of Mixed Micelle Growth†

Langmuir ◽  
2005 ◽  
Vol 21 (22) ◽  
pp. 9803-9808 ◽  
Author(s):  
Yael G. Mishael ◽  
Paul L. Dubin
Keyword(s):  
Mixed Micelle

Development of Curcumin-Loaded Polymeric Mixed Micelle for Skin Moisturizing Antioxidant Formulation

2021 ◽  
Vol 901 ◽  
pp. 98-103
Author(s):  
Sunee Channarong ◽  
Parapat Sobharaksha ◽  
Chanchai Sardseangjun ◽  
Panipak Vasvid
Keyword(s):  
Mixed Micelle ◽  
Polymeric Micelles ◽  
Entrapment Efficiency ◽  
Water Soluble ◽  
Poloxamer 407 ◽  
Average Particle ◽  
Yellow Color ◽  
Stability Data ◽  
Hydrogenated Castor Oil ◽  
The Stability

Abstract The aim of this study was to fabricate curcumin-loaded polymeric mixed micelle which was a new nanocarrier of therpeutic agent for skin uses. Curcumin was extracted from dried turmeric rhizomes using ethanol and recrystallized. The purity of curcumin was 79±3.6 %w/w. Six curcumin-loaded polymeric micelles (PM1-PM6) were prepared by simple dissolution method using poloxamer 407 (5% and 10%) as a main core structure. PEG-40 hydrogenated castor oil (PEG-40HCO) was incorporated at two percentages (2.5% and 5.0%) to study the effect on the nanoparticle characteristics. The average particle sizes of PM1-PM6 were in the range of 33.3±6.6 nm to 171.3±52.8 nm. The entrapment efficiency and the loading capacity of curcumin were in the range of 47.45%-77.35% and 0.048%w/w-0.078%w/w, respectively. When PEG-40HCO was incorporated in to the polymeric micelles, the particle size decreased and the entrapment efficiency increased. Thus, PM4 and PM5 were selected for further study. Moisturizing antioxidant creams containing 0.005%w/w of curcumin loaded in PM4, PM5 and curcumin simply dissolved in propylene glycol (PG) were formulated. The resulted formulations showed good spreadability and good characteristics. After being subjected to accelerated test, all of the formulations remained with characteristic color, pH and showed no phase separation. The stability data showed that the moisturizing antioxidant creams were stable for the whole 3 months after storage at accelerated temperature (45°C/75%RH). The study demonstrated that polymeric mixed micelle spontaneously encapsulated a poorly water-soluble curcumin and increased the solubility up to 250 folds. The developed moisturizing cream containing 0.005%w/w of curcumin resulted a greenish-yellow color preparation. It had tolerable physicochemical properties based on curcumin content, pH and viscosity under the harsh condition. The cream also had satisfactory antioxidant activity, which can be regarded as an effective and acceptable therapeutic or skincare products for topical uses.

Determination of Surfactants Based on Mixed-Micelle Formation

1995 ◽  
Vol 67 (11) ◽  
pp. 1872-1880 ◽  
Author(s):  
Dolores. Sicilia ◽  
Soledad. Rubio ◽  
Dolores. Perez-Bendito
Keyword(s):  
Mixed Micelle ◽  
Micelle Formation ◽  
Mixed Micelle Formation

Surface protection of an organic pigment based on a modification using a mixed-micelle system

2016 ◽  
Vol 127 ◽  
pp. 100-109 ◽  
Author(s):  
Erika Švara Fabjan ◽  
Mojca Otoničar ◽  
Miran Gaberšček ◽  
Andrijana Sever Škapin
Keyword(s):  
Mixed Micelle ◽  
Organic Pigment ◽  
Surface Protection ◽  
Micelle System

Synthesis and characterization of ratiometric nanosensors for pH quantification: a mixed micelle approach

2012 ◽  
Vol 48 (39) ◽  
pp. 4776 ◽  
Author(s):  
E. K. Pramod Kumar ◽  
Kristoffer Almdal ◽  
Thomas L. Andresen
Keyword(s):  
Mixed Micelle ◽  
Synthesis And Characterization

A Stimulated Mixed Micelle System for In Vitro Study on Chemo-Photodynamic Therapy

2015 ◽  
Vol 16 (2) ◽  
pp. 188-197 ◽  
Author(s):  
Ching-Yi Chen ◽  
Chao-Kai Syu ◽  
Hsin Chang Lin
Keyword(s):  
Photodynamic Therapy ◽  
Mixed Micelle ◽  
In Vitro Study ◽  
Vitro Study ◽  
Micelle System

scholarly journals Traceless native chemical ligation of lipid-modified peptide surfactants by mixed micelle formation

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Shuaijiang Jin ◽  
Roberto J. Brea ◽  
Andrew K. Rudd ◽  
Stuart P. Moon ◽  
Matthew R. Pratt ◽  
...  
Keyword(s):  
Mixed Micelle ◽  
Micelle Formation ◽  
Native Chemical Ligation ◽  
Chemical Ligation ◽  
Mixed Micelle Formation

scholarly journals Why is glycocholic acid sodium salt better than deoxycholic acid sodium salt for the preparation of mixed micelle injections?

2019 ◽  
Vol 7 (11) ◽  
pp. 3675-3680
Author(s):  
Tao Wang ◽  
Liao Shen ◽  
Lijun Sun ◽  
Yadan Zhang ◽  
Haiyan Li ◽  
...  
Keyword(s):  
Sodium Salt ◽  
Mixed Micelle ◽  
Deoxycholic Acid ◽  
Glycocholic Acid ◽  
Acid Sodium Salt ◽  
Better Than

scholarly journals Solutol®HS15+pluronicF127 and Solutol®HS15+pluronicL61 mixed micelle systems for oral delivery of genistein

2019 ◽  
Vol Volume 13 ◽  
pp. 1947-1956 ◽  
Author(s):  
Pinggang Ding ◽  
Yuxuan Chen ◽  
Guangshang Cao ◽  
Hongxue Shen ◽  
Jianming Ju ◽  
...  
Keyword(s):  
Oral Delivery ◽  
Mixed Micelle
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