Target-Specific Cellular Uptake of PLGA Nanoparticles Coated with Poly(l-lysine)−Poly(ethylene glycol)−Folate Conjugate

Langmuir ◽  
2005 ◽  
Vol 21 (19) ◽  
pp. 8852-8857 ◽  
Author(s):  
Sun Hwa Kim ◽  
Ji Hoon Jeong ◽  
Ki Woo Chun ◽  
Tae Gwan Park
Keyword(s):  
Ethylene Glycol ◽  
Cellular Uptake ◽  
Plga Nanoparticles ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Folate Conjugate

Controlling the morphology of glyco-nanoparticles in water using block copolymer mixtures: the effect on cellular uptake

2015 ◽  
Vol 6 (45) ◽  
pp. 7812-7820 ◽  
Author(s):  
Aydan Dag ◽  
Hongxu Lu ◽  
Martina Stenzel
Keyword(s):  
Block Copolymer ◽  
Ethylene Glycol ◽  
Cellular Uptake ◽  
Methyl Ether ◽  
Butyl Acrylate ◽  
Diblock Copolymers ◽  
Ethyl Acrylate ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Glycol Methyl Ether

Poly[(2-(α-d-mannosyloxy)ethyl acrylate)-block-(n-butyl acrylate)], P(ManA-b-BA), and poly[poly(ethylene glycol) methyl ether acrylate]-block-(n-butyl acrylate)], P(OEGMEA-b-BA) diblock copolymers were mixed at various ratios to generate self-assembled structures of different morphologies.

Cellular uptake and transfection activity of DNA complexes based on poly(ethylene glycol)-poly(l-glutamine) copolymer with PAMAM G2

2013 ◽  
Vol 1 (38) ◽  
pp. 5114 ◽  
Author(s):  
Shirong Pan ◽  
Duanwen Cao ◽  
Rong Fang ◽  
Wu Yi ◽  
Huan Huang ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Cellular Uptake ◽  
Poly Ethylene Glycol ◽  
Dna Complexes ◽  
Poly Ethylene

scholarly journals Impact of the conjugation of antibodies to the surfaces of polymer nanoparticles on the immune cell targeting abilities

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Na Kyeong Lee ◽  
Chi-Pin James Wang ◽  
Jaesung Lim ◽  
Wooram Park ◽  
Ho-Keun Kwon ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Immune Cell ◽  
Plga Nanoparticles ◽  
Antibody Fragments ◽  
Full Length ◽  
Cell Targeting ◽  
Poly Ethylene Glycol ◽  
Delivery Technique ◽  
Poly Ethylene

AbstractAntibodies have been widely used to provide targeting ability and to enhance bioactivity owing to their high specificity, availability, and diversity. Recent advances in biotechnology and nanotechnology permit site-specific engineering of antibodies and their conjugation to the surfaces of nanoparticles (NPs) in various orientations through chemical conjugations and physical adhesions. This study proposes the conjugation of poly(lactic-co-glycolic acid) (PLGA) NPs with antibodies by using two distinct methods, followed by a comparison between the cell-targeting efficiencies of both techniques. Full-length antibodies were conjugated to the PLGA-poly(ethylene glycol)-carboxylic acid (PLGA-PEG-COOH) NPs through the conventional carbodiimide coupling reaction, and f(ab′)2 antibody fragments were conjugated to the PLGA-poly(ethylene glycol)-maleimide(PLGA-PEG-Mal) NPs through interactions between the f(ab′)2 fragment thiol groups and the maleimide located on the nanoparticle surface. The results demonstrate that the PLGA nanoparticles conjugated with the f(ab′)2 antibody fragments had a higher targeting efficiency in vitro and in vivo than that of the PLGA nanoparticles conjugated with the full-length antibodies. The results of this study can be built upon to design a delivery technique for drugs through biocompatible nanoparticles.

Poly(ethylene glycol) or poly(2-ethyl-2-oxazoline) – A systematic comparison of PLGA nanoparticles from the bottom up

2020 ◽  
Vol 134 ◽  
pp. 109801 ◽  
Author(s):  
Michael Dirauf ◽  
Christian Grune ◽  
Christine Weber ◽  
Ulrich S. Schubert ◽  
Dagmar Fischer
Keyword(s):  
Ethylene Glycol ◽  
Plga Nanoparticles ◽  
Poly Ethylene Glycol ◽  
Bottom Up ◽  
Systematic Comparison ◽  
Poly Ethylene

Poly(ethylene glycol) shell-sheddable nanomicelle prodrug of camptothecin with enhanced cellular uptake

2013 ◽  
Vol 105 ◽  
pp. 294-302 ◽  
Author(s):  
Qinge Wu ◽  
Fang Du ◽  
Yu Luo ◽  
Wei Lu ◽  
Jin Huang ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Cellular Uptake ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene
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