Oil Core/Polymer Shell Microcapsules by Internal Phase Separation from Emulsion Droplets. II:  Controlling the Release Profile of Active Molecules

Langmuir ◽  
2005 ◽  
Vol 21 (12) ◽  
pp. 5278-5284 ◽  
Author(s):  
Peter J. Dowding ◽  
Rob Atkin ◽  
Brian Vincent ◽  
Philippe Bouillot
Keyword(s):  
Phase Separation ◽  
Release Profile ◽  
Polymer Shell ◽  
Emulsion Droplets ◽  
Internal Phase ◽  
Core Polymer

scholarly journals Preparation of Aqueous Core/Polymer Shell Microcapsules by Internal Phase Separation

2004 ◽  
Vol 37 (21) ◽  
pp. 7979-7985 ◽  
Author(s):  
Rob Atkin ◽  
Paul Davies ◽  
John Hardy ◽  
Brian Vincent
Keyword(s):  
Phase Separation ◽  
Polymer Shell ◽  
Internal Phase ◽  
Aqueous Core ◽  
Core Polymer

Preparation and Characterization of Silicone Liquid Core/Polymer Shell Microcapsules via Internal Phase Separation

2014 ◽  
Vol 299 (10) ◽  
pp. 1259-1267 ◽  
Author(s):  
Lidia González ◽  
Malgorzata Kostrzewska ◽  
Ma Baoguang ◽  
Li Li ◽  
Jens Henrik Hansen ◽  
...  
Keyword(s):  
Phase Separation ◽  
Liquid Core ◽  
Polymer Shell ◽  
Internal Phase ◽  
Silicone Liquid ◽  
Core Polymer

scholarly journals Fabrication of Multi-Layered Microspheres Based on Phase Separation for Drug Delivery

Micromachines ◽  
2021 ◽  
Vol 12 (6) ◽  
pp. 723
Author(s):  
He Xia ◽  
Ang Li ◽  
Jia Man ◽  
Jianyong Li ◽  
Jianfeng Li
Keyword(s):  
Aqueous Solution ◽  
Phase Separation ◽  
Gastric Fluid ◽  
Simulated Gastric Fluid ◽  
Sustained Drug Release ◽  
Simulated Intestinal Fluid ◽  
Glycol Diacrylate ◽  
Emulsion Droplets ◽  
Collection Tube ◽  
Poly Ethylene

In this work, we used a co-flow microfluidic device with an injection and a collection tube to generate droplets with different layers due to phase separation. The phase separation system consisted of poly(ethylene glycol) diacrylate 700 (PEGDA 700), PEGDA 250, and sodium alginate aqueous solution. When the mixture droplets formed in the outer phase, PEGDA 700 in the droplets would transfer into the outer aqueous solution, while PEGDA 250 still stayed in the initial droplet, breaking the miscibility equilibrium of the mixture and triggering the phase separation. As the phase separation proceeded, new cores emerged in the droplets, gradually forming the second and third layers. Emulsion droplets with different layers were polymerized under ultraviolet (UV) irradiation at different stages of phase separation to obtain microspheres. Microspheres with different layers showed various release behaviors in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). The release rate decreased with the increase in the number of layers, which showed a potential application in sustained drug release.

Controlling the internal morphology of aqueous core-PLGA shell microcapsules: promoting the internal phase separation via alcohol addition

2019 ◽  
Vol 24 (6) ◽  
pp. 671-679 ◽  
Author(s):  
Samer R. Abulateefeh ◽  
Ghada K. Al-Adhami ◽  
Mahmoud Y. Alkawareek ◽  
Alaaldin M. Alkilany
Keyword(s):  
Phase Separation ◽  
Internal Morphology ◽  
Internal Phase ◽  
Aqueous Core

Size-Dependent Phase Separation in Emulsion Droplets

ChemPhysChem ◽  
2018 ◽  
Vol 19 (16) ◽  
pp. 1995-1998 ◽  
Author(s):  
Jia Man ◽  
Steven Chien ◽  
Shuaishuai Liang ◽  
Jiang Li ◽  
Haosheng Chen
Keyword(s):  
Phase Separation ◽  
Size Dependent ◽  
Emulsion Droplets
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