Poly(l-lysine)-graft-poly(ethylene glycol) Assembled Monolayers on Niobium Oxide Surfaces:  A Quantitative Study of the Influence of Polymer Interfacial Architecture on Resistance to Protein Adsorption by ToF-SIMS and in Situ OWLS

Langmuir ◽  
2003 ◽  
Vol 19 (22) ◽  
pp. 9216-9225 ◽  
Author(s):  
Stéphanie Pasche ◽  
Susan M. De Paul ◽  
Janos Vörös ◽  
Nicholas D. Spencer ◽  
Marcus Textor
Keyword(s):  
Ethylene Glycol ◽  
Protein Adsorption ◽  
Quantitative Study ◽  
Niobium Oxide ◽  
Oxide Surfaces ◽  
Poly Ethylene Glycol ◽  
Tof Sims ◽  
Assembled Monolayers ◽  
Poly Ethylene

scholarly journals Poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) Copolymers for the Formulation of In Situ Forming Depot Long-Acting Injectables

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 605
Author(s):  
Marie-Emérentienne Cagnon ◽  
Silvio Curia ◽  
Juliette Serindoux ◽  
Jean-Manuel Cros ◽  
Feifei Ng ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Surface Erosion ◽  
Sustained Delivery ◽  
Trimethylene Carbonate ◽  
Poly Ethylene Glycol ◽  
In Situ Forming ◽  
Poly Ethylene ◽  
Long Acting

This article describes the utilization of (methoxy)poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) ((m)PEG–PTMC) diblock and triblock copolymers for the formulation of in situ forming depot long-acting injectables by solvent exchange. The results shown in this manuscript demonstrate that it is possible to achieve long-term drug deliveries from suspension formulations prepared with these copolymers, with release durations up to several months in vitro. The utilization of copolymers with different PEG and PTMC molecular weights affords to modulate the release profile and duration. A pharmacokinetic study in rats with meloxicam confirmed the feasibility of achieving at least 28 days of sustained delivery by using this technology while showing good local tolerability in the subcutaneous environment. The characterization of the depots at the end of the in vivo study suggests that the rapid phase exchange upon administration and the surface erosion of the resulting depots are driving the delivery kinetics from suspension formulations. Due to the widely accepted utilization of meloxicam as an analgesic drug for animal care, the results shown in this article are of special interest for the development of veterinary products aiming at a very long-term sustained delivery of this therapeutic molecule.

Measurements of Interbilayer Forces and Protein Adsorption on Uncharged Lipid Bilayers Displaying Poly(ethylene glycol) Chains†

Biochemistry ◽  
2000 ◽  
Vol 39 (12) ◽  
pp. 3441-3451 ◽  
Author(s):  
Nadezhda V. Efremova ◽  
Bruce Bondurant ◽  
David F. O'Brie ◽  
Deborah E. Leckband
Keyword(s):  
Ethylene Glycol ◽  
Protein Adsorption ◽  
Lipid Bilayers ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Poly(ethylene glycol) Grafting to Poly(ether imide) Membranes: Influence on Protein Adsorption and Thrombocyte Adhesion

2013 ◽  
Vol 13 (12) ◽  
pp. 1720-1729 ◽  
Author(s):  
Axel T. Neffe ◽  
Maik von Ruesten-Lange ◽  
Steffen Braune ◽  
Karola Luetzow ◽  
Toralf Roch ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Protein Adsorption ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene
Sign in / Sign up

Export Citation Format

Share Document