Formation of Droplets and Mixing in Multiphase Microfluidics at Low Values of the Reynolds and the Capillary Numbers

Joshua D. Tice; Helen Song; Adam D. Lyon; Rustem F. Ismagilov

doi:10.1021/la030090w

Formation of Droplets and Mixing in Multiphase Microfluidics at Low Values of the Reynolds and the Capillary Numbers

Langmuir ◽

10.1021/la030090w ◽

2003 ◽

Vol 19 (22) ◽

pp. 9127-9133 ◽

Cited By ~ 486

Author(s):

Joshua D. Tice ◽

Helen Song ◽

Adam D. Lyon ◽

Rustem F. Ismagilov

Keyword(s):

Multiphase Microfluidics

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Piezoelectric Actuation in Multiphase Microfluidics

Encyclopedia of Microfluidics and Nanofluidics ◽

10.1007/978-1-4614-5491-5_1766 ◽

2015 ◽

pp. 2735-2743 ◽

Cited By ~ 1

Author(s):

Jie Xu ◽

Daniel Attinger

Keyword(s):

Piezoelectric Actuation ◽

Multiphase Microfluidics

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Engineering Drug Delivery Vehicles With Multiphase Microfluidics

ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology ◽

10.1115/nemb2013-93028 ◽

2013 ◽

Author(s):

Ho Cheung Shum ◽

Tiantian Kong ◽

Zhou Liu ◽

Yang Song

Keyword(s):

Drug Delivery ◽

Complex Structures ◽

Nonspherical Particles ◽

Two Phase ◽

Drug Delivery Vehicles ◽

Sequential Release ◽

Aqueous Two Phase Systems ◽

Delivery Vehicles ◽

Phase Systems ◽

Multiphase Microfluidics

In our work, we propose the use of multiphase microfluidics to prepare drug delivery vehicles with complex structures, such as core-shell capsules, multicompartment microspheres and nonspherical particles; by tailoring the spatial distribution of drugs, unconventional drug release profiles can be achieved. To avoid the use of harmful organic solvents, we introduce the use of aqueous two-phase systems in microfluidics to generate the emulsion templates for making these novel delivery vehicles. By manipulating the interfacial characteristics of the emulsion templates, complex structures with hydrophilic and hydrophobic compartments can be prepared for separate encapsulation and sequential release of both hydrophilic and hydrophobic drugs. We will discuss the fundamental problems that need to be addressed to generate these drug delivery vehicles and highlight their potential by demonstrating their release characteristics.

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