A Surfactant Transition Metal Chelate

Langmuir ◽  
2003 ◽  
Vol 19 (11) ◽  
pp. 4859-4862 ◽  
Author(s):  
David A. Jaeger ◽  
Mary F. Peacock ◽  
D. Scott Bohle
1989 ◽  
Vol 11 ◽  
pp. 221-226 ◽  
Author(s):  
I.E. Uflyand ◽  
I.V. Kokoreva ◽  
A.G. Starikov ◽  
V.N. Sheinker ◽  
A.D. Pomogailo

1993 ◽  
Vol 3 (3) ◽  
pp. 102-104 ◽  
Author(s):  
Vladimir I. Minkin ◽  
Nikolai V. Volbushko ◽  
Mikhail S. Korobov ◽  
Leonid E. Nivorozhkin

Drug Research ◽  
2020 ◽  
Vol 70 (12) ◽  
pp. 583-592
Author(s):  
Md. Jamal Hossain ◽  
Mohammad A. Rashid ◽  
Md. Zakir Sultan

AbstractThis current research aimed to establish the most required pharmacodynamics parameters of two transition metal complexes of an antimicrobial drug secnidazole. The spectroscopic fluorescence quenching strategy was outlined to evaluate the binding mechanism and binding affinity of nickel (II) and chromium (III) complexes of secnidazole with bovine serum albumin (BSA). The conformational modifications and the interacting patterns of the protein due to the interaction of the parent compound of the metal complexes have been investigated by molecular docking approach. The ligand-protein interactions were confirmed by the spectral quelling of the serum protein’s intensity in the presence of metal chelate of secnidazole. The quenching mechanism was an endothermic dynamic process. The calculated thermodynamic factors delineated van der Waals interactions mainly influenced the spontaneous process. The UV-fluorescence curves were studied to establish the energy transformation profile according to the Förster resonance energy transfer (FRET) theory. The double-logarithm plot exhibited the binding number that ensured the drug-protein interaction was at a 1:1 ratio. The compared binding constants dictated that both metal chelates gained higher binding affinity, longer half-life, and achieved the capacity to show the pharmacological effects by a lower dose than the parent molecule.


2016 ◽  
Vol 450 ◽  
pp. 251-257 ◽  
Author(s):  
Jianfeng Yuan ◽  
Mianbin Wu ◽  
Jianping Lin ◽  
Lirong Yang

Polyhedron ◽  
2018 ◽  
Vol 151 ◽  
pp. 74-81 ◽  
Author(s):  
Inna M. Grigorieva ◽  
Tatiyana V. Serebryanskaya ◽  
Yuri V. Grigoriev ◽  
Alexander S. Lyakhov ◽  
Ludmila S. Ivashkevich ◽  
...  

1987 ◽  
Vol 26 (13) ◽  
pp. 2171-2176 ◽  
Author(s):  
Martin M. Finnegan ◽  
Tammy G. Lutz ◽  
William O. Nelson ◽  
Alexis Smith ◽  
Chris Orvig

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