Surface selective chemical modification of fluoropolymer using aluminum deposition

Langmuir ◽  
1991 ◽  
Vol 7 (10) ◽  
pp. 2146-2152 ◽  
Author(s):  
Neil B. McKeown ◽  
Peter G. Kalman ◽  
Rana. Sodhi ◽  
Alex D. Romaschin ◽  
Michael. Thompson
Keyword(s):  
Chemical Modification ◽  
Selective Chemical ◽  
Aluminum Deposition

Identifying the Active Site of N-Doped Graphene for Oxygen Reduction by Selective Chemical Modification

2018 ◽  
Vol 3 (4) ◽  
pp. 986-991 ◽  
Author(s):  
Tao Wang ◽  
Zhi-Xin Chen ◽  
Yu-Gang Chen ◽  
Li-Jun Yang ◽  
Xiao-Dong Yang ◽  
...  
Keyword(s):  
Chemical Modification ◽  
Oxygen Reduction ◽  
Active Site ◽  
Doped Graphene ◽  
Selective Chemical

Activated Human Hageman Factor (XII)*

1965 ◽  
Vol 14 (01/02) ◽  
pp. 001-011 ◽  
Author(s):  
R. J Speer ◽  
Helen Ridgway ◽  
J. M Hill
Keyword(s):  
Chemical Modification ◽  
Mechanism Of Action ◽  
Chemical Characteristics ◽  
Factor Xii ◽  
Improved Method ◽  
Enzymatic Assays ◽  
Hageman Factor ◽  
Selective Chemical ◽  
Physical And Chemical ◽  
Shed Light

SummaryAn improved method for the isolation of highly purified active human Hageman factor has been described. An overall recovery of 25% with a purification of 106 has been achieved. Certain of the physical and chemical characteristics of XII have been elucidated. Selective chemical modification of functional groups and a variety of enzymatic assays have been employed in an effort to shed light on the mechanism of action of this procoagulant.

nSite-Selective, Chemical Modification of Protein at Aromatic Side Chain and Their Emergent Applications

2021 ◽  
Vol 28 ◽  
Author(s):  
Arnab Chowdhury ◽  
Saurav Chatterjee ◽  
Akumlong Pongen ◽  
Dhanjit Sarania ◽  
Nitesh Mani Tripathi ◽  
...  
Keyword(s):  
Chemical Modification ◽  
Chemical Reactivity ◽  
Future Perspective ◽  
Side Chain ◽  
Aromatic Side Chain ◽  
Therapeutic Applications ◽  
Selective Chemical ◽  
Photocatalytic Reactions ◽  
Metal Catalyzed ◽  
Site Selective

: Site-selective chemical modification of protein side chain has probed enormous opportunities in the fundamental understanding of cellular biology and therapeutic applications. Primarily, in the field of biopharmaceutical where formulation of bioconjugates is found to be potential medicine than an individual constituent. In this regard, Lysine and Cysteine are the most widely used endogenous amino acid for these purposes. Recently, the aromatic side chain residues (Trp, Tyr, and His) that are low abundant in protein have gained more attention in therapeutic applications due to their advantages of chemical reactivity and specificity. This review discusses the site-selective bioconjugation methods for aromatic side chains (Trp, Tyr and His) and highlights the developed strategies in the last three years, along with their applications. Also, the review highlights the prevalent methods published earlier. We have examined that metal-catalyzed and photocatalytic reactions are gaining more attention for bioconjugation, though their practical operation is under development. The review has been summarized with the future perspective of protein and peptide conjugations contemplating therapeutic applications and challenges.

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