Methyl iodide thermal reactions when chemisorbed on nickel(100) surfaces. [Erratum to document cited in CA117(16):158421g]

Langmuir ◽  
1993 ◽  
Vol 9 (3) ◽  
pp. 880-880 ◽  
Author(s):  
Sariwan Tjandra ◽  
Francisco Zaera
Keyword(s):  
Methyl Iodide ◽  
Thermal Reactions

THE CHEMICAL FATE OF RECOIL IODINE ATOMS IN IODINE–METHYL IODIDE SOLUTIONS

1964 ◽  
Vol 42 (12) ◽  
pp. 2684-2694
Author(s):  
N. V. Klassen ◽  
A. P. Baerg
Keyword(s):  
Methyl Iodide ◽  
Mole Fraction ◽  
Neutron Irradiation ◽  
Iodine Concentration ◽  
Thermal Reactions ◽  
Chemical Fate ◽  
Diffusion Controlled ◽  
Organic Products

The organic yield of recoil 126I, produced by the 14 MeV neutron irradiation of iodine–methyl iodide solutions, was examined over iodine concentrations from 0.34 mole fraction iodine to "pure" methyl iodide. By correcting for exchange between I2 and methyl iodide, the initial organic yield at very low iodine concentrations was found to be 57%. The time for one-half of the I2 to exchange with CH3I was found to decrease with decreasing iodine concentration. At all iodine concentrations the organic products containing 126I consisted mainly of CH3I and CH2I2. The formation of products is discussed in terms of thermal reactions, diffusion-controlled reactions in the spurs, and hot reactions.

Methyl iodide thermal reactions when chemisorbed on nickel(100) surfaces

Langmuir ◽  
1992 ◽  
Vol 8 (9) ◽  
pp. 2090-2097 ◽  
Author(s):  
Sariwan Tjandra ◽  
Francisco Zaera
Keyword(s):  
Methyl Iodide ◽  
Thermal Reactions

Femtosecond reaction dynamics of Rydberg states. Methyl iodide

1993 ◽  
Vol 214 (3-4) ◽  
pp. 281-289 ◽  
Author(s):  
M.H.M. Janssen ◽  
M. Dantus ◽  
H. Guo ◽  
A.H. Zewail
Keyword(s):  
Methyl Iodide ◽  
Rydberg States ◽  
Reaction Dynamics

scholarly journals Improved synthesis of SV2A targeting radiotracer [11C]UCB-J

2019 ◽  
Vol 4 (1) ◽  
Author(s):  
Johanna Rokka ◽  
Eva Schlein ◽  
Jonas Eriksson
Keyword(s):  
Methyl Iodide ◽  
Water Solution ◽  
Synthesis Method ◽  
Radiochemical Yield ◽  
Preparative Hplc ◽  
Step Method ◽  
Synaptic Density ◽  
Excellent Starting Point ◽  
Starting Point

Abstract Introduction [11C]UCB-J is a tracer developed for PET (positron emission tomography) that has high affinity towards synaptic vesicle glycoprotein 2A (SV2A), a protein believed to participate in the regulation of neurotransmitter release in neurons and endocrine cells. The localisation of SV2A in the synaptic terminals makes it a viable target for in vivo imaging of synaptic density in the brain. Several SV2A targeting compounds have been evaluated as PET tracers, including [11C]UCB-J, with the aim to facilitate studies of synaptic density in neurological diseases. The original two-step synthesis method failed in our hands to produce sufficient amounts of [11C]UCB-J, but served as an excellent starting point for further optimizations towards a high yielding and simplified one-step method. [11C]Methyl iodide was trapped in a clear THF-water solution containing the trifluoroborate substituted precursor, potassium carbonate and palladium complex. The resulting reaction mixture was heated at 70 °C for 4 min to produce [11C]UCB-J. Results After semi-preparative HPLC purification and reformulation in 10% ethanol/phosphate buffered saline, the product was obtained in 39 ± 5% radiochemical yield based on [11C]methyl iodide, corresponding to 1.8 ± 0.5 GBq at EOS. The radiochemical purity was > 99% and the molar activity was 390 ± 180 GBq/μmol at EOS. The product solution contained < 2 ppb palladium. Conclusions A robust and high yielding production method has been developed for [11C]UCB-J, suitable for both preclinical and clinical PET applications.

THE KINETICS OF THE THERMAL REACTIONS OF ETHYLENE OXIDE

1963 ◽  
Vol 41 (12) ◽  
pp. 2956-2961 ◽  
Author(s):  
M. Lynne Neufeld ◽  
Arthur T. Blades
Keyword(s):  
Free Radicals ◽  
Free Radical ◽  
Ethylene Oxide ◽  
Thermal Reactions ◽  
Kinetics Of

The thermal reactions of ethylene oxide in the presence of an excess of propylene have been studied as a function of pressure and it has been found that there are two sets of products, acetaldehyde and free radicals, presumably methyl and formyl. These products are believed to arise from an excited acetaldehyde intermediate. Some evidence has been obtained for the occurrence of a surface-catalyzed rearrangement to acetaldehyde but the free radical products are uninfluenced by surface.

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