Revealing the Dual Role of Hydrogen for Growth Inhibition and Defect Healing in Polycyclic Aromatic Hydrocarbon Formation: QM/MD Simulations

2013 ◽  
Vol 4 (14) ◽  
pp. 2323-2327 ◽  
Author(s):  
Hai-Bei Li ◽  
Alister J. Page ◽  
Stephan Irle ◽  
Keiji Morokuma
Keyword(s):  
Polycyclic Aromatic Hydrocarbon ◽  
Aromatic Hydrocarbon ◽  
Growth Inhibition ◽  
Md Simulations ◽  
Dual Role ◽  
Defect Healing ◽  
Polycyclic Aromatic ◽  
Hydrocarbon Formation

Formation of phenylacetylene and benzocyclobutadiene in the ortho-benzyne + acetylene reaction

2021 ◽  
Author(s):  
Morgan McCabe ◽  
Patrick Hemberger ◽  
Dario Campisi ◽  
Jeger Broxterman ◽  
Engelbert Reusch ◽  
...  
Keyword(s):  
Polycyclic Aromatic Hydrocarbon ◽  
Aromatic Hydrocarbon ◽  
Polycyclic Aromatic ◽  
Hydrocarbon Formation

Ortho-benzyne is a potentially important precursor for polycyclic aromatic hydrocarbon formation, but much is still unknown about its chemistry. In this work, we report on a combined experimental and theoretical...

scholarly journals A polycyclic aromatic hydrocarbon-enriched environmental chemical mixture enhances AhR, antiapoptotic signaling and a proliferative phenotype in breast cancer cells

2020 ◽  
Author(s):  
Larisa M Gearhart-Serna ◽  
John B Davis ◽  
Mohit Kumar Jolly ◽  
Nishad Jayasundara ◽  
Scott J Sauer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Polycyclic Aromatic Hydrocarbon ◽  
Aromatic Hydrocarbon ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Complex Mixture ◽  
Environmental Chemicals ◽  
Er Positive ◽  
Polycyclic Aromatic

Abstract Emerging evidence suggests the role of environmental chemicals, in particular endocrine-disrupting chemicals (EDCs), in progression of breast cancer and treatment resistance, which can impact survival outcomes. However, most research tends to focus on tumor etiology and the effect of single chemicals, offering little insight into the effects of realistic complex mixture exposures on tumor progression. Herein, we investigated the effect of a polycyclic aromatic hydrocarbon (PAH)-enriched EDC mixture in a panel of normal and breast cancer cells and in a tumor organoid model. Cells or organoids in culture were treated with EDC mixture at doses estimated from US adult intake of the top four PAH compounds within the mixture from the National Health and Nutrition Examination Survey database. We demonstrate that low-dose PAH mixture (6, 30 and 300 nM) increased aryl hydrocarbon receptor (AhR) expression and CYP activity in estrogen receptor (ER) positive but not normal mammary or ER-negative breast cancer cells, and that upregulated AhR signaling corresponded with increased cell proliferation and expression of antiapoptotic and antioxidant proteins XIAP and SOD1. We employed a mathematical model to validate PAH-mediated increases in AhR and XIAP expression in the MCF-7 ER-positive cell line. Furthermore, the PAH mixture caused significant growth increases in ER-negative breast cancer cell derived 3D tumor organoids, providing further evidence for the role of a natural-derived PAH mixture in enhancing a tumor proliferative phenotype. Together, our integrated cell signaling, computational and phenotype analysis reveals the underlying mechanisms of EDC mixtures in breast cancer progression and survival.

Modeling of nitro-polycyclic aromatic hydrocarbon formation and decay in the atmosphere

1995 ◽  
Vol 29 (10) ◽  
pp. 1171-1181 ◽  
Author(s):  
Zhihua Fan ◽  
Danhua Chen ◽  
Parag Birla ◽  
Richard M. Kamens
Keyword(s):  
Polycyclic Aromatic Hydrocarbon ◽  
Aromatic Hydrocarbon ◽  
Polycyclic Aromatic ◽  
Hydrocarbon Formation

The Role of Polycyclic Aromatic Hydrocarbon Metabolism in Dimethylbenz[a]anthracene-Induced Pre-B Lymphocyte Apoptosis

1999 ◽  
Vol 161 (1) ◽  
pp. 10-22 ◽  
Author(s):  
K.K. Mann ◽  
R.A. Matulka ◽  
M.E. Hahn ◽  
A.F. Trombino ◽  
B.P. Lawrence ◽  
...  
Keyword(s):  
Polycyclic Aromatic Hydrocarbon ◽  
Aromatic Hydrocarbon ◽  
B Lymphocyte ◽  
Lymphocyte Apoptosis ◽  
Polycyclic Aromatic

The Influence of Cooking Methods and Some Marinades on Polycyclic Aromatic Hydrocarbon Formation in Beef Meat

2017 ◽  
Vol 40 (2) ◽  
pp. 195-205 ◽  
Author(s):  
Özlem Kılıç Büyükkurt ◽  
Elif Aykın Dinçer ◽  
İhsan Burak Çam ◽  
Cihadiye Candal ◽  
Mustafa Erbaş
Keyword(s):  
Polycyclic Aromatic Hydrocarbon ◽  
Aromatic Hydrocarbon ◽  
Cooking Methods ◽  
Beef Meat ◽  
Polycyclic Aromatic ◽  
Hydrocarbon Formation
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