Blood–brain barrier properties of human immunodeficiency virus antiretrovirals

1999 ◽  
Vol 88 (10) ◽  
pp. 950-954 ◽  
Author(s):  
Mehran Yazdanian
Keyword(s):  
Human Immunodeficiency Virus ◽  
Blood Brain Barrier ◽  
Barrier Properties ◽  
Brain Barrier ◽  
Blood Brain ◽  
Immunodeficiency Virus

The Primary Phase of Infection by Pathogenic Simian–Human Immunodeficiency Virus Results in Disruption of the Blood–Brain Barrier

2003 ◽  
Vol 19 (10) ◽  
pp. 837-846 ◽  
Author(s):  
Edward B. Stephens ◽  
Dinesh K. Singh ◽  
M. Eric Kohler ◽  
Mollie Jackson ◽  
Erik Pacyniak ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Blood Brain Barrier ◽  
Primary Phase ◽  
Brain Barrier ◽  
Blood Brain ◽  
Immunodeficiency Virus

scholarly journals Effect of human immunodeficiency virus on blood-brain barrier integrity and function: an update

2015 ◽  
Vol 9 ◽  
Author(s):  
Venkata Subba Rao Atluri ◽  
Melissa Hidalgo ◽  
Thangavel Samikkannu ◽  
Kesava Rao Venkata Kurapati ◽  
Rahul Dev Jayant ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Barrier Integrity ◽  
Blood Brain ◽  
Immunodeficiency Virus ◽  
And Function ◽  
Blood Brain Barrier Integrity

scholarly journals Intra-blood-brain barrier synthesis of human immunodeficiency virus antigen and antibody in humans and chimpanzees.

1987 ◽  
Vol 84 (11) ◽  
pp. 3876-3880 ◽  
Author(s):  
J. Goudsmit ◽  
L. G. Epstein ◽  
D. A. Paul ◽  
H. J. van der Helm ◽  
G. J. Dawson ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Blood Brain Barrier ◽  
Virus Antigen ◽  
Brain Barrier ◽  
Blood Brain ◽  
Immunodeficiency Virus

scholarly journals Human Immunodeficiency Virus Type 1 Infection Increases the In Vivo Capacity of Peripheral Monocytes To Cross the Blood-Brain Barrier into the Brain and the In Vivo Sensitivity of the Blood-Brain Barrier to Disruption by Lipopolysaccharide

2008 ◽  
Vol 82 (15) ◽  
pp. 7591-7600 ◽  
Author(s):  
Hongwei Wang ◽  
Jinglin Sun ◽  
Harris Goldstein
Keyword(s):  
Human Immunodeficiency Virus ◽  
Blood Brain Barrier ◽  
Human Immunodeficiency Virus Type ◽  
Brain Barrier ◽  
Blood Brain ◽  
Immunodeficiency Virus ◽  
The Brain ◽  
Hiv 1

ABSTRACT Human immunodeficiency virus type 1 (HIV-1), introduced into the brain by HIV-1-infected monocytes which migrate across the blood-brain barrier (BBB), infects resident macrophages and microglia and initiates a process that causes HIV-1-associated neurocognitive disorders. The mechanism by which HIV-1 infection circumvents the BBB-restricted passage of systemic leukocytes into the brain and disrupts the integrity of the BBB is not known. Circulating lipopolysaccharide (LPS), which can compromise the integrity of the BBB, is significantly increased in HIV-1-infected individuals. We hypothesized that HIV-1 infection increases monocyte capacity to migrate across the BBB, which is further facilitated by a compromise of BBB integrity mediated by the increased systemic LPS levels present in HIV-1-infected individuals. To investigate this possibility, we examined the in vivo BBB migration of monocytes derived from our novel mouse model, JR-CSF/EYFP mice, which are transgenic for both a long terminal repeat-regulated full-length infectious HIV-1 provirus and ROSA-26-regulated enhanced yellow fluorescent protein. We demonstrated that JR-CSF/EYFP mouse monocytes displayed an increased capacity to enter the brain by crossing either an intact BBB or a BBB whose integrity was partially compromised by systemic LPS. We also demonstrated that the JR-CSF mouse BBB was more susceptible to disruption by systemic LPS than the control wild-type mouse BBB. These results demonstrated that HIV-1 infection increased the ability of monocytes to enter the brain and increased the sensitivity of the BBB to disruption by systemic LPS, which is elevated in HIV-1-infected individuals. These mice represent a new in vivo system for studying the mechanism by which HIV-1-infected monocytes migrate into the brain.

scholarly journals Blood-Brain Barrier Tight Junction Disruption in Human Immunodeficiency Virus-1 Encephalitis

1999 ◽  
Vol 155 (6) ◽  
pp. 1915-1927 ◽  
Author(s):  
Linda M. Dallasta ◽  
Liubomir A. Pisarov ◽  
James E. Esplen ◽  
Jonette V. Werley ◽  
Ashlee V. Moses ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Tight Junction ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain ◽  
Immunodeficiency Virus ◽  
Tight Junction Disruption ◽  
Human Immunodeficiency Virus 1
Sign in / Sign up

Export Citation Format

Share Document