Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 2. Prediction of blood–brain barrier penetration

1999 ◽  
Vol 88 (8) ◽  
pp. 815-821 ◽  
Author(s):  
David E. Clark
Keyword(s):  
Surface Area ◽  
Blood Brain Barrier ◽  
Transport Phenomena ◽  
Molecular Surface ◽  
Brain Barrier ◽  
Molecular Surface Area ◽  
Blood Brain ◽  
Barrier Penetration ◽  
Rapid Calculation ◽  
Polar Molecular Surface Area

scholarly journals Association Between Vancomycin Blood Brain Barrier Penetration and Clinical Response in Postsurgical Meningitis

2017 ◽  
Vol 20 ◽  
pp. 161 ◽  
Author(s):  
Qing Wang ◽  
Si Chen ◽  
Yan-Gang Zhou ◽  
Ping Xu ◽  
Yi-Ping Liu ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Clinical Response ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Serum Samples ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Blood Brain ◽  
Barrier Penetration ◽  
White Blood Cell Counts

PURPOSE: This study investigated the association between vancomycin blood brain barrier penetration and clinical response in patients with postsurgical meningitis. METHODS: Adult patients with postsurgical meningitis were recruited. Eligible patients received vancomycin 500 mg every 6 h for at least 5 days. On day 3 or 4, cerebrospinal fluid (CSF) and simultaneous serum samples were obtained to determine CSF minimum concentrations (Cmin), serum Cmin and CSF to serum Cmin ratio. RESULTS: Twenty-two patients (14 men and 8 women; mean age of 52.6± 12.1 years) were recruited. The vancomycin Cmin was 3.63 ± 1.64 mg/L in CSF and 13.38 ± 5.36 mg/L in serum, with the CSF to serum Cmin ratio of 0.291 ± 0.118. The Cmin in serum and in CSF showed a significant correlation (p=0.005, r =0.575). The vancomycin CSF Cmin had a significant correlation with the decline of white blood cell counts (WBCs) in CSF (p=0.003, r =0.609). CSF Cmin, serum Cmin and CSF to serum Cmin ratio all showed no significant correlation with clinical response (p=0.335, 0.100, 0.679, respectively). CONCLUSIONS: There was a positive correlation between serum Cmin and CSF Cmin. However, only CSF Cmin is positively correlated with WBCs improvement in CSF. All other parameters such as serum Cmin, CSF Cmin and CSF to serum Cmin ratio had no correlation with clinical response. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

scholarly journals A TfR-Binding Cystine-Dense Peptide Promotes Blood–Brain Barrier Penetration of Bioactive Molecules

2020 ◽  
Vol 432 (14) ◽  
pp. 3989-4009 ◽  
Author(s):  
Zachary R. Crook ◽  
Emily Girard ◽  
Gregory P. Sevilla ◽  
Morgan Merrill ◽  
Della Friend ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Bioactive Molecules ◽  
Brain Barrier ◽  
Blood Brain ◽  
Barrier Penetration

Automatic QSAR modeling of ADME properties: blood–brain barrier penetration and aqueous solubility

2008 ◽  
Vol 22 (6-7) ◽  
pp. 431-440 ◽  
Author(s):  
Olga Obrezanova ◽  
Joelle M. R. Gola ◽  
Edmund J. Champness ◽  
Matthew D. Segall
Keyword(s):  
Blood Brain Barrier ◽  
Aqueous Solubility ◽  
Brain Barrier ◽  
Qsar Modeling ◽  
Blood Brain ◽  
Barrier Penetration ◽  
Adme Properties
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