Synthesis, stereoselective enzymatic hydrolysis, and skin permeation of diastereomeric propranolol ester prodrugs

1999 ◽  
Vol 88 (5) ◽  
pp. 544-550 ◽  
Author(s):  
Chandrasekhar Udata ◽  
Giridhar Tirucherai ◽  
Ashim K. Mitra
Keyword(s):  
Enzymatic Hydrolysis ◽  
Skin Permeation ◽  
Ester Prodrugs

Skin permeation and ex vivo skin metabolism of O-acyl haloperidol ester prodrugs

2009 ◽  
Vol 367 (1-2) ◽  
pp. 44-50 ◽  
Author(s):  
Andrew P. Morris ◽  
Keith R. Brain ◽  
Charles M. Heard
Keyword(s):  
Ex Vivo ◽  
Skin Permeation ◽  
Skin Metabolism ◽  
Ester Prodrugs

scholarly journals Evaluation of Physicochemical Properties, Skin Permeation and Accumulation Profiles of Ketorolac Fatty Ester Prodrugs

2007 ◽  
Vol 30 (11) ◽  
pp. 2211-2216 ◽  
Author(s):  
Krishna Hari Bhandari ◽  
Madhuri Newa ◽  
Sung II Yoon ◽  
Jung Sun Kim ◽  
Ki Young Jang ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Skin Permeation ◽  
Fatty Ester ◽  
Ester Prodrugs

Metabolic Studies of Vitamin K1-14C and Menadione-14C in the Normal and Hepatectomized Rats

1968 ◽  
Vol 19 (03/04) ◽  
pp. 383-388 ◽  
Author(s):  
R Losito ◽  
C. A Owen ◽  
E. V Flock ◽  
Keyword(s):  
Enzymatic Hydrolysis ◽  
Oral Anticoagulants ◽  
Urinary Metabolites ◽  
The Other ◽  
Vitamin K1 ◽  
Vitamin K3 ◽  
Metabolic Studies ◽  
Intact Rats

SummaryThe metabolism of vitamin K1- 14C and menadione-14C (vitamin K3-14C) was studied in normal and hepateetomized rats. After the administration of menadione, about 70% of the 14C was excreted in the urine in 24 hrs in both types of rats. Two urinary metabolites were identified by enzymatic hydrolysis: one a glucuronide and the other a sulfate of reduced menadione. Thus, the liver is not necessary for the metabolism of menadione. In the vitamin K1 studies, the intact rats excreted only 10% of the 14C and the hepatectomized rats excreted less than 0.5%. The retention of vitamin K1 may explain its superiority over menadione as an antidote for overdosages of oral anticoagulants.

From biorefineries to bioproducts: conversion of pretreated pulp from biorefining streams to lignocellulose nanofibers

TAPPI Journal ◽  
2019 ◽  
Vol 18 (4) ◽  
pp. 233-241
Author(s):  
CHENGGUI SUN ◽  
RICHARD CHANDRA ◽  
YAMAN BOLUK
Keyword(s):  
Energy Consumption ◽  
Enzymatic Hydrolysis ◽  
Rheological Behavior ◽  
Material Basis ◽  
Softwood Pulp ◽  
Energy Consumptions ◽  
Hardwood Pulp ◽  
The Stability ◽  
Lignocellulose Nanofibers

This study investigates the use of pretreatment and enzymatic hydrolysis side streams and conversion to lignocellulose nanofibers. We used a steam-exploded and partial enzymatic hydrolyzed hardwood pulp and an organosolv pretreated softwood pulp to prepare lignocellulose nanofibers (LCNF) via microfluidization. The energies applied on fibrillation were estimated to examine the energy consumption levels of LCNF production. The energy consumptions of the fibrillation processes of the hardwood LCNF production and the softwood LCNF production were about 7040-14080 kWh/ton and 4640 kWh/ton on a dry material basis, respectively. The morphology and dimension of developed hardwood and softwood LCNFs and the stability and rheological behavior of their suspensions were investigated and are discussed.

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