Chemical stability of peptides in polymers. 1. Effect of water on peptide deamidation in poly(vinyl alcohol) and poly(vinyl pyrrolidone) matrixes

1999 ◽  
Vol 88 (10) ◽  
pp. 1073-1080 ◽  
Author(s):  
Mei C. Lai ◽  
Michael J. Hageman ◽  
Richard L. Schowen ◽  
Ronald T. Borchardt ◽  
Elizabeth M. Topp
Keyword(s):  
Chemical Stability ◽  
Vinyl Alcohol ◽  
Vinyl Pyrrolidone ◽  
Poly Vinyl Alcohol ◽  
Effect Of Water ◽  
Poly Vinyl Pyrrolidone

scholarly journals PREPARATION AND CHARACTERIZATION OF POLY (VINYL ALCOHOL)–POLY (VINYL PYRROLIDONE) MUCOADHESIVE BUCCAL PATCHES FOR DELIVERY OF LIDOCAINE HCL

2018 ◽  
Vol 10 (1) ◽  
pp. 115 ◽  
Author(s):  
Napaphak Jaipakdee ◽  
Thaned Pongjanyakul ◽  
Ekapol Limpongsa
Keyword(s):  
Vinyl Alcohol ◽  
Vinyl Pyrrolidone ◽  
Poly Vinyl Alcohol ◽  
Scanning Calorimetry ◽  
X Ray ◽  
Casting Technique ◽  
In Vitro Permeation ◽  
Lidocaine Hcl ◽  
Poly Vinyl Pyrrolidone

Objective: The objectives of this study were to prepare and characterize a buccal mucoadhesive patch using poly (vinyl alcohol) (PVA), poly (vinyl pyrrolidone) (PVP) as a mucoadhesive matrix, Eudragit S100 as a backing layer, and lidocaine HCl as a model drug.Methods: Lidocaine HCl buccal patches were prepared using double casting technique. Molecular interactions in the polymer matrices were studied using attenuated total reflectance-fourier transform infrared spectroscopy (ATR-FTIR), differential scanning calorimetry (DSC) and X-ray diffractometry. Mechanical and mucoadhesive properties were measured using texture analyzer. In vitro permeation of lidocaine HCl from the patch was conducted using Franz diffusion cell.Results: Both of the free and lidocaine HCl patches were smooth and transparent, with good flexibility and strength. ATR-FTIR, DSC and X-ray diffractometry studies confirmed the interaction of PVA and PVP. Mechanical properties of matrices containing 60% PVP were significantly lower than those containing 20% PVP (*P<0.05). Mucoadhesive properties had a tendency to decrease with the concentration of PVP in the patch. The patch containing 60% PVP had significantly lower muco-adhesiveness than those containing 20% PVP (*P<0.05). In vitro permeation revealed that the pattern of lidocaine HCl permeation started with an initial fast permeation, followed by a slower permeation rate. The initial permeation fluxes follow the zero-order model of which rate was not affected by the PVP concentrations in the PVA/PVP matrix.Conclusion: Mucoadhesive buccal patches fabricated with PVA/PVP were successfully prepared. Incorporation of PVP in PVA/PVP matrix affected the strength of polymeric matrix and mucoadhesive property of patches.

Characterization of polymeric biocomposite based on poly(vinyl alcohol) and poly(vinyl pyrrolidone)

2006 ◽  
Vol 27 (2) ◽  
pp. 147-152 ◽  
Author(s):  
Vladimír Sedlařík ◽  
Nabanita Saha ◽  
Ivo Kuřitka ◽  
Petr Sáha
Keyword(s):  
Vinyl Alcohol ◽  
Vinyl Pyrrolidone ◽  
Poly Vinyl Alcohol ◽  
Poly Vinyl Pyrrolidone

Characterization of associating hydrogels of poly(vinyl alcohol) and poly(vinyl pyrrolidone)

2009 ◽  
Vol 112 (1) ◽  
pp. 541-549 ◽  
Author(s):  
X. Liu ◽  
G. Fussell ◽  
M. Marcolongo ◽  
A. M. Lowman
Keyword(s):  
Vinyl Alcohol ◽  
Vinyl Pyrrolidone ◽  
Poly Vinyl Alcohol ◽  
Poly Vinyl Pyrrolidone

Solid Films of Blended Poly(Vinyl Alcohol)/Poly(Vinyl Pyrrolidone) for Topical S-Nitrosoglutathione and Nitric Oxide Release

2005 ◽  
Vol 94 (5) ◽  
pp. 994-1003 ◽  
Author(s):  
Amedea Barozzi Seabra ◽  
Lilian Lúcia da Rocha ◽  
Marcos N. Eberlin ◽  
Marcelo Ganzarolli de Oliveira
Keyword(s):  
Nitric Oxide ◽  
Vinyl Alcohol ◽  
Vinyl Pyrrolidone ◽  
Poly Vinyl Alcohol ◽  
Nitric Oxide Release ◽  
Solid Films ◽  
Poly Vinyl Pyrrolidone
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