In Vitro Evaluation of Pluronic F127-Based Controlled-Release Ocular Delivery Systems for Pilocarpine

1998 ◽  
Vol 87 (2) ◽  
pp. 226-230 ◽  
Author(s):  
Suketu D. Desai ◽  
James Blanchard
Keyword(s):  
Controlled Release ◽  
Delivery Systems ◽  
Pluronic F127 ◽  
Ocular Delivery ◽  
In Vitro Evaluation

scholarly journals RANITIDINE CONTROLLED RELEASE ANTI-REFLUX SUSPENSION FOR GASTRO-OESOPHAGEAL REFLUX DISEASE AND IT’S IN VITRO EVALUATION

2019 ◽  
Vol 11 (1) ◽  
pp. 74
Author(s):  
Sangmesh R. Torne ◽  
Sheela A. ◽  
Sarada N. C.
Keyword(s):  
Controlled Release ◽  
Reflux Disease ◽  
Oesophageal Reflux ◽  
Gelling Agent ◽  
Acid Neutralizing Capacity ◽  
Simulated Gastric Fluid ◽  
In Vitro Evaluation ◽  
Oesophageal Reflux Disease ◽  
Neutralizing Capacity

Objective: The aim of this work was to develop triple action controlled release anti-reflux suspension of ranitidine and its in-vitro evaluation of anti-reflux and controlled release properties.Methods: The formulation was optimized using sodium alginate as a gelling agent along with calcium carbonate, sodium bicarbonate, magnesium hydroxide, aluminium hydroxide as alkalizing agents and colloidal microcrystalline cellulose (MCC) as a suspending agent at various concentrations and arrived at an optimized formulation for its best quality attributes. To avoid initial release in water before administration, ranitidine coated MCC sphere was incorporated into powder formulation and subjected to in vitro characteristics like raft strength, acid neutralizing capacity, pH, viscosity and dissolution study. The obtained results were assessed using Minitab 17 statistical software to conclude the study design.Results: Formulation containing 300 mg of ranitidine along with 750 mg alginate has shown better anti-reflux characteristics like raft strength 18±2g, acid neutralizing capacity 17±1 mEq compared to other formulations. This formulation has also shows zero-order controlled release in the simulated gastric fluid (SGF) up to 10 h compared to the formulation without alginate. Further, to this optimized formulation has shown negligible change in the assay of ranitidine even after 3 mo at 40 °C temperature and 75% RH.Conclusion: The developed stable sustained release powder for suspension has the combined therapeutic efficacy as an antacid and anti-reflux drug suitable for the management and treatment of gastro-oesophageal reflux disease (GERD) unlike the existing drugs possessing only reflux resistance action.

scholarly journals Development and In Vitro Evaluation of Lyotropic Liquid Crystals for the Controlled Release of Dexamethasone

Polymers ◽  
2017 ◽  
Vol 9 (12) ◽  
pp. 330 ◽  
Author(s):  
Márcia Oyafuso ◽  
Flávia Carvalho ◽  
Tatiane Takeshita ◽  
Ana de Souza ◽  
Daniele Araújo ◽  
...  
Keyword(s):  
Liquid Crystals ◽  
Controlled Release ◽  
Lyotropic Liquid Crystals ◽  
In Vitro Evaluation

Fabrication of Dissolvable Microneedle Patches Using an Innovative Laser-Cut Mould Design to Shortlist Potentially Transungual Delivery Systems: In Vitro Evaluation

2019 ◽  
Vol 20 (5) ◽  
Author(s):  
Esra’a Albarahmieh ◽  
Labiba AbuAmmouneh ◽  
Zaina Kaddoura ◽  
Farah AbuHantash ◽  
Bashar A. Alkhalidi ◽  
...  
Keyword(s):  
Delivery Systems ◽  
In Vitro Evaluation ◽  
Transungual Delivery ◽  
Mould Design
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