Ion Mobility Measurement by Dc Tomography in an Rf Quadrupole Ion Trap

2000 ◽  
Vol 104 (21) ◽  
pp. 5059-5065 ◽  
Author(s):  
Wolfgang R. Plass ◽  
Lynn A. Gill ◽  
Huy A. Bui ◽  
R. Graham Cooks
Keyword(s):  
Ion Mobility ◽  
Ion Trap ◽  
Quadrupole Ion Trap ◽  
Mobility Measurement

Gas-Phase Ion Mobility Studies of Amines and Polyether/Amine Complexes Using Tandem Quadrupole Ion Trap/Ion Mobility Spectrometry

2000 ◽  
Vol 6 (2) ◽  
pp. 213-218 ◽  
Author(s):  
Colin S. Creaser ◽  
John R. Griffiths ◽  
Brian M. Stockton
Keyword(s):  
Gas Phase ◽  
Ion Mobility Spectrometry ◽  
Ion Mobility ◽  
Ion Trap ◽  
Quadrupole Ion Trap ◽  
Amine Complexes ◽  
Ion Molecule Reactions ◽  
Ion Mobility Spectra ◽  
Pharmacologically Active ◽  
Tandem Quadrupole

The gas-phase positive ion mobility spectra of isomeric amines and polyether/amine complexes have been measured using a tandem quadrupole ion trap/ion mobility spectrometer. Ion mobilities of isomeric amines in helium, determined relative to benzene at pressures in the range 1–2 Torr, vary with the structure of the amine. The ability of quadrupole ion trap/ion mobility spectrometry to differentiate between a pharmacologically-active substance and an associated isomeric amine is demonstrated. Non-covalent complexes of cyclic and acyclic polyethers with protonated amines were generated by ion/molecule reactions in the ion trap and analysed by ion mobility spectrometry. The ion mobilities in helium may be interpreted in terms of the preferred conformations for these complexes. The use of polyether hosts as shift compounds for enhancing the relative mobilities of small amine guest ions is proposed.

scholarly journals Characterisation of Anthracyclines from a Cosmomycin D-Producing Species of Streptomyces by Collisionally-Activated Dissociation and Ion Mobility Mass Spectrometry

2009 ◽  
Vol 15 (2) ◽  
pp. 73-81 ◽  
Author(s):  
Celine Kelso ◽  
Juan Diego Rojas ◽  
Renata L.A. Furlan ◽  
Gabriel Padilla ◽  
Jennifer L. Beck
Keyword(s):  
Mass Spectrometer ◽  
Ion Mobility ◽  
Ion Trap ◽  
Parent Compound ◽  
Quadrupole Ion Trap ◽  
Travelling Wave ◽  
Hydroxyl Groups ◽  
Exact Mass ◽  
Electrospray Ionisation ◽  
Collisionally Activated Dissociation

Cultures of cosmomycin D-producing Streptomyces olindensis ICB20 that were propagated for many generations underwent mutations that resulted in production of a range of related anthracyclines by the bacteria. The anthracyclines that retained the two trisaccharide chains of the parent compound were separated by HPLC. Exact mass determination of these compounds revealed that they differed from cosmomycin D (CosD) in that they contained one to three fewer oxygen atoms (loss of hydroxyl groups). Some of the anthracyclines that were separated by HPLC had the same mass. The location from which the hydroxyl groups had been lost relative to CosD (on the aglycone and/or on the sugar residues) was probed by collisionally-activated dissociation using an electrospray ionisation linear quadrupole ion trap mass spectrometer. The presence of anthracyclines with the same mass, but different structure, was confirmed using an electrospray ionisation travelling wave ion mobility mass spectrometer.

scholarly journals Quadrupole Ion Trap Mass Spectrometer for Ice Giant Atmospheres Exploration

2021 ◽  
Vol 217 (1) ◽  
Author(s):  
J. Simcic ◽  
D. Nikolić ◽  
A. Belousov ◽  
D. Atkinson ◽  
C. Lee ◽  
...  
Keyword(s):  
Mass Spectrometer ◽  
Ion Trap ◽  
Quadrupole Ion Trap ◽  
Atomic Mass ◽  
Charge Ratio ◽  
Inlet System ◽  
Mass Spectrometers ◽  
Ion Trap Mass Spectrometer ◽  
Entry Probe ◽  
Composition Measurements

AbstractTo date, a variety of different types of mass spectrometers have been utilized on missions to study the composition of atmospheres of solar system bodies, including Venus, Mars, Jupiter, Titan, the moon, and several comets. With the increasing interest in future small probe missions, mass spectrometers need to become even more versatile, lightweight, compact, and sensitive.For in situ exploration of ice giant atmospheres, the highest priority composition measurements are helium and the other noble gases, noble gas isotopes, including 3He/4He, and other key isotopes like D/H. Other important but lower priority composition measurements include abundances of volatiles C, N, S, and P; isotopes 13C/12C, 15N/14N, 18O/17O/16O; and disequilibrium species PH3, CO, AsH3, GeH4, and SiH4. Required measurement accuracies are largely defined by the accuracies achieved by the Galileo (Jupiter) probe Neutral Mass Spectrometer and Helium Abundance Detectors, and current measurement accuracies of solar abundances.An inherent challenge of planetary entry probe mass spectrometers is the introduction of material to be sampled (gas, solid, or liquid) into the instrument interior, which operates at a vacuum level. Atmospheric entry probe mass spectrometers typically require a specially designed sample inlet system, which ideally provides highly choked, nearly constant mass-flow intake over a large range of ambient pressures. An ice giant descent probe would have to operate for 1-2 hours over a range of atmospheric pressures, possibly covering 2 or more orders of magnitude, from the tropopause near 100 mbar to at least 10 bars, in an atmospheric layer of depth beneath the tropopause of about 120 km at Neptune and about 150 km at Uranus.The Jet Propulsion Laboratory’s Quadrupole Ion Trap Mass Spectrometer (QITMS) is being developed to achieve all of these requirements. A compact, wireless instrument with a mass of only 7.5 kg, and a volume of 7 liters (7U), the JPL QITMS is currently the smallest flight mass spectrometer available for possible use on planetary descent probes as well as small bodies, including comet landers and surface sample return missions. The QITMS is capable of making measurements of all required constituents in the mass range of 1–600 atomic mass units (u) at a typical speed of 50 mass spectra per second, with a sensitivity of up to $10^{13}$ 10 13  counts/mbar/sec and mass resolution of $m/\Delta m=18000$ m / Δ m = 18000 at m/q = 40. (Throughout this paper we use the unit of m/q = u/e for the mass-to-charge ratio, where atomic mass unit and elementary charge are $1~\text{u} = 1.66\times 10^{-27}~\text{kg}$ 1 u = 1.66 × 10 − 27 kg and $1\text{e} = 1.6\times 10^{-19}$ 1 e = 1.6 × 10 − 19 C, respectively.) The QITMS features a novel MEMS-based inlet system driven by a piezoelectric actuator that continuously regulates gas flow at inlet pressures of up to 100 bar.In this paper, we present an overview of the QITMS capabilities, including instrument design and characteristics of the inlet system, as well as the most recent results from laboratory measurements in different modes of operation, especially suitable for ice giant atmospheres exploration.

Axial ion motion within the quadrupole ion trap elucidated by dc pulse tomography

2000 ◽  
Vol 194 (2-3) ◽  
pp. 225-234 ◽  
Author(s):  
Carsten Weil ◽  
J.Mitchell Wells ◽  
H Wollnik ◽  
R.Graham Cooks
Keyword(s):  
Ion Trap ◽  
Quadrupole Ion Trap ◽  
Ion Motion

Stability of ion motion in the quadrupole ion trap driven by rectangular waveform voltages

2003 ◽  
Vol 230 (1) ◽  
pp. 65-70 ◽  
Author(s):  
Won-Wook Lee ◽  
Soon-Ki Min ◽  
Cha-Hwan Oh ◽  
Pill-Soo Kim ◽  
Seok-Ho Song ◽  
...  
Keyword(s):  
Ion Trap ◽  
Quadrupole Ion Trap ◽  
Ion Motion ◽  
Rectangular Waveform
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