Dynamics and Kinetic Isotope Effect for the Double Proton Transfer in Formamidine Monohydrated Complex Using Direct Semiempirical Dynamics Calculation

1998 ◽  
Vol 102 (18) ◽  
pp. 3025-3036 ◽  
Author(s):  
Yongho Kim
Keyword(s):  
Proton Transfer ◽  
Isotope Effect ◽  
Kinetic Isotope Effect ◽  
Double Proton Transfer ◽  
Kinetic Isotope ◽  
Dynamics Calculation ◽  
The Double Proton Transfer

Kinetic isotope effect and tunnelling in the proton transfer reaction between 2,4,6-trinitrotoluene and 1,1′,3,3′-tetramethylguanidine in dimethylformamide solvent

1979 ◽  
Vol 57 (6) ◽  
pp. 669-672 ◽  
Author(s):  
Arnold Jarczewski ◽  
Przemyslaw Pruszynski ◽  
Kenneth T. Leffek
Keyword(s):  
Proton Transfer ◽  
Isotope Effect ◽  
Kinetic Isotope Effect ◽  
Transfer Reaction ◽  
Proton Transfer Reaction ◽  
Deuterium Isotope Effect ◽  
Kinetic Isotope ◽  
Enthalpy Of Activation ◽  
Entropy Of Activation ◽  
Large Primary

The proton transfer reaction between 2,4,6-trinitrotoluene and 1,1′,3,3′-tetramethylguanidine in dimethylformamide solvent shows a large primary deuterium isotope effect, kH/kD = 24.3 at 0 °C and 16.9 at 20 °C. The enthalpy of activation difference (ΔHD≠ − ΔHH≠) = 2.6 ± 0.4 kcal mol−1 and the entropy of activation difference (ΔSD≠ − ΔSH≠) = 3.4 ± 1.3 cal mol−1 K−1. This isotope effect, when fitted to Bell's equation, indicates that there is a considerable contribution to this reaction from tunnelling of the proton through the potential energy barrier.

Ketonization equilibria of phenol in aqueous solution

1999 ◽  
Vol 77 (5-6) ◽  
pp. 605-613 ◽  
Author(s):  
Marco Capponi ◽  
Ivo G Gut ◽  
Bruno Hellrung ◽  
Gaby Persy ◽  
Jakob Wirz
Keyword(s):  
Aqueous Solution ◽  
Proton Transfer ◽  
Isotope Effect ◽  
Kinetic Isotope Effect ◽  
Flash Photolysis ◽  
Equilibrium Constants ◽  
Thermodynamic Cycle ◽  
Acidity Constant ◽  
Kinetic Isotope ◽  
Carbon Acids

The two keto tautomers of phenol (1), cyclohexa-2,4-dienone (2) and cyclohexa-2,5-dienone (3), were generated by flash photolysis of appropriate precursors in aqueous solution, and the pH-rate profiles of their enolization reactions, 2 –> 1 and 3 –> 1, were measured. The rates of the reverse reactions, 1 –> 2 and 1 –> 3, were determined from the rates of acid-catalyzed hydron exchange at the ortho- and para-positions of 1; the magnitude of the kinetic isotope effect was assessed by comparing the rates of hydrogenation of phenol-2t and -2d. The ratios of the enolization and ketonization rate constants provide the equilibrium constants of enolization, pKE(2, aq, 25°C) = -12.73 ± 0.12 and pKE(3, aq, 25°C) = -10.98 ± 0.15. Combination with the acidity constant of phenol also defines the acidity constants of 2 and 3 through a thermodynamic cycle. These ketones are remarkably strong carbon acids: pKa(2) = -2.89 ± 0.12 and pKa(3) = -1.14 ± 0.15. They disappear by proton transfer to the solvent with lifetimes, τ(2) = 260 μs and τ(3) = 13 ms, that are insensitive to pH in the range from 3-10.Key words: proton transfer, tautomers, flash photolysis, kinetic isotope effect, pH-rate profiles.

Intramolecular kinetic isotope effect in gas-phase proton-transfer reactions

1979 ◽  
Vol 101 (8) ◽  
pp. 2242-2243 ◽  
Author(s):  
Keith M. Wellman ◽  
Maria E. Victoriano ◽  
Paulo C. Isolani ◽  
Jose M. Riveros
Keyword(s):  
Proton Transfer ◽  
Gas Phase ◽  
Isotope Effect ◽  
Kinetic Isotope Effect ◽  
Transfer Reactions ◽  
Kinetic Isotope ◽  
Proton Transfer Reactions
Sign in / Sign up

Export Citation Format

Share Document