Empirical and Accurate Method for the Three-Dimensional Electrostatic Potential (EM-ESP) of Biomolecules

2010 ◽  
Vol 114 (12) ◽  
pp. 4351-4357 ◽  
Author(s):  
Qi-Shi Du ◽  
Cheng-Hua Wang ◽  
Yu-Ting Wang ◽  
Ri-Bo Huang
Keyword(s):  
Electrostatic Potential ◽  
Three Dimensional ◽  
Accurate Method

scholarly journals Applications of Biomaterials in 3D Cell Culture and Contributions of 3D Cell Culture to Drug Development and Basic Biomedical Research

2021 ◽  
Vol 22 (5) ◽  
pp. 2491
Author(s):  
Yujin Park ◽  
Kang Moo Huh ◽  
Sun-Woong Kang
Keyword(s):  
Cell Culture ◽  
Three Dimensional ◽  
3D Culture ◽  
3D Cell Culture ◽  
Accurate Method ◽  
New Drugs ◽  
Toxicity Screening ◽  
Cellular Functions ◽  
Toxicity Of Drugs ◽  
External Stimuli

The process of evaluating the efficacy and toxicity of drugs is important in the production of new drugs to treat diseases. Testing in humans is the most accurate method, but there are technical and ethical limitations. To overcome these limitations, various models have been developed in which responses to various external stimuli can be observed to help guide future trials. In particular, three-dimensional (3D) cell culture has a great advantage in simulating the physical and biological functions of tissues in the human body. This article reviews the biomaterials currently used to improve cellular functions in 3D culture and the contributions of 3D culture to cancer research, stem cell culture and drug and toxicity screening.

scholarly journals Initial boundary value problems for the three-dimensional compressible elastic Navier-Stokes-Poisson equations

2021 ◽  
Vol 10 (1) ◽  
pp. 1356-1383
Author(s):  
Yong Wang ◽  
Wenpei Wu
Keyword(s):  
Equilibrium State ◽  
Boundary Value Problems ◽  
Electrostatic Potential ◽  
Boundary Value ◽  
Three Dimensional ◽  
Initial Boundary ◽  
Navier Stokes ◽  
Initial Boundary Value Problems ◽  
Poisson Equations ◽  
Initial Boundary Value

Abstract We study the initial-boundary value problems of the three-dimensional compressible elastic Navier-Stokes-Poisson equations under the Dirichlet or Neumann boundary condition for the electrostatic potential. The unique global solution near a constant equilibrium state in H 2 space is obtained. Moreover, we prove that the solution decays to the equilibrium state at an exponential rate as time tends to infinity. This is the first result for the three-dimensional elastic Navier-Stokes-Poisson equations under various boundary conditions for the electrostatic potential.

scholarly journals Quantitative Determination of Cd in Soil Using Laser-Induced Breakdown Spectroscopy in Air and Ar Conditions

Molecules ◽  
2018 ◽  
Vol 23 (10) ◽  
pp. 2492 ◽  
Author(s):  
Xiaodan Liu ◽  
Fei Liu ◽  
Weihao Huang ◽  
Jiyu Peng ◽  
Tingting Shen ◽  
...  
Keyword(s):  
Heavy Metal ◽  
Least Squares ◽  
Three Dimensional ◽  
Accurate Method ◽  
Laser Induced Breakdown Spectroscopy ◽  
Quantitative Detection ◽  
Support Vector ◽  
Least Squares Regression ◽  
Breakdown Spectroscopy ◽  
Laser Induced Breakdown

Rapid detection of Cd content in soil is beneficial to the prevention of soil heavy metal pollution. In this study, we aimed at exploring the rapid quantitative detection ability of laser- induced breakdown spectroscopy (LIBS) under the conditions of air and Ar for Cd in soil, and finding a fast and accurate method for quantitative detection of heavy metal elements in soil. Spectral intensity of Cd and system performance under air and Ar conditions were analyzed and compared. The univariate model and multivariate models of partial least-squares regression (PLSR) and least-squares support vector machine (LS-SVM) of Cd under the air and Ar conditions were built, and the LS-SVM model under the Ar condition obtained the best performance. In addition, the principle of influence of Ar on LIBS detection was investigated by analyzing the three-dimensional profile of the ablation crater. The overall results indicated that LIBS combined with LS-SVM under the Ar condition could be a useful tool for the accurate quantitative detection of Cd in soil and could provide reference for environmental monitoring.

scholarly journals Prediction of Dynamic Stability Using Mapped Chebyshev Pseudospectral Method

2018 ◽  
Vol 2018 ◽  
pp. 1-14 ◽  
Author(s):  
Jae-Young Choi ◽  
Dong Kyun Im ◽  
Jangho Park ◽  
Seongim Choi
Keyword(s):  
Unsteady Flow ◽  
Three Dimensional ◽  
Pseudospectral Method ◽  
Accurate Method ◽  
Spectral Approach ◽  
Fourier Pseudospectral Method ◽  
Chebyshev Pseudospectral Method ◽  
Fourier Pseudospectral ◽  
Chebyshev Pseudospectral ◽  
Good Agreement

A mapped Chebyshev pseudospectral method is extended to solve three-dimensional unsteady flow problems. As the classical Chebyshev spectral approach can lead to numerical instabilities due to ill conditioning of the spectral matrix, the Chebyshev points are evenly redistributed over the domain by an inverse sine mapping function. The mapped Chebyshev pseudospectral method can be used as an alternative time-spectral approach that uses a Chebyshev collocation operator to approximate the time derivative terms in the unsteady flow governing equations, and the method can make general applications to both nonperiodic and periodic problems. In this study, the mapped Chebyshev pseudospectral method is employed to solve three-dimensional periodic problem to verify the spectral accuracy and computational efficiency with those of the Fourier pseudospectral method and the time-accurate method. The results show a good agreement with both of the Fourier pseudospectral method and the time-accurate method. The flow solutions also demonstrate a good agreement with the experimental data. Similar to the Fourier pseudospectral method, the mapped Chebyshev pseudospectral method approximates the unsteady flow solutions with a precise accuracy at a considerably effective computational cost compared to the conventional time-accurate method.

scholarly journals Reconstruction of three-dimensional maps based on closed-form solutions of the variational problem of multisensor data registration

2019 ◽  
Vol 484 (6) ◽  
pp. 672-677
Author(s):  
A. V. Vokhmintcev ◽  
A. V. Melnikov ◽  
K. V. Mironov ◽  
V. V. Burlutskiy
Keyword(s):  
Closed Form ◽  
Large Scale ◽  
Three Dimensional ◽  
Dynamic Environment ◽  
Closed Form Solution ◽  
Point Clouds ◽  
Accurate Method ◽  
Form Solution ◽  
Closed Form Solutions ◽  
Reconstruction Methods

A closed-form solution is proposed for the problem of minimizing a functional consisting of two terms measuring mean-square distances for visually associated characteristic points on an image and meansquare distances for point clouds in terms of a point-to-plane metric. An accurate method for reconstructing three-dimensional dynamic environment is presented, and the properties of closed-form solutions are described. The proposed approach improves the accuracy and convergence of reconstruction methods for complex and large-scale scenes.

scholarly journals Three-dimensional reconstructions of electrostatic potential distributions with 1.5-nm resolution using off-axis electron holography

Microscopy ◽  
2011 ◽  
Vol 61 (2) ◽  
pp. 77-84 ◽  
Author(s):  
Toshiaki Tanigaki ◽  
Shinji Aizawa ◽  
Takahiro Suzuki ◽  
Akira Tonomura
Keyword(s):  
Electrostatic Potential ◽  
Three Dimensional ◽  
Electron Holography

Accelerating the Calibration of Multihole Pressure Probes by Applying Advanced Computational Methods

2005 ◽  
Vol 127 (3) ◽  
pp. 425-430 ◽  
Author(s):  
Arnoud R. C. Franken ◽  
Paul C. Ivey
Keyword(s):  
Computational Methods ◽  
Three Dimensional ◽  
Field Measurements ◽  
Cost Effective ◽  
Accurate Method ◽  
Pressure Probe ◽  
Calibration Data ◽  
Essential Information ◽  
Individual Probe ◽  
Probe Calibration

The miniature multihole pneumatic pressure probe is widely regarded as a cost-effective, easy-to-use, and accurate method for performing two- or three-dimensional flow field measurements in turbomachinery. The major downside to the use of these probes is that the influence of fabrication imperfections on probe characteristics necessitates an extensive and highly time-intensive and, therefore, costly calibration of each individual probe. Unless these probes can be fabricated to such standards that make individual probe calibrations superfluous, the only way to significantly reduce the time and costs associated with probe calibration is to shorten the calibration process. The latter is only possible if all essential information can be obtained from less calibration data. This paper describes an approach to the calibration of a series of multihole pressure probes in which advanced computational methods are used to make this possible. By exploiting the key features of a probe’s characteristic this approach requires only a fraction of the size of a conventional calibration database for the accurate modeling of the relationships between port pressures and flow conditions. As a result, calibration time and costs can be reduced without the sacrifice of quality.

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