scholarly journals A Theoretical and Experimental Approach to the Compaction Process of DNA by Dioctadecyldimethylammonium Bromide/Zwitterionic Mixed Liposomes

2009 ◽  
Vol 113 (47) ◽  
pp. 15648-15661 ◽  
Author(s):  
Alberto Rodríguez-Pulido ◽  
Alberto Martín-Molina ◽  
César Rodríguez-Beas ◽  
Oscar Llorca ◽  
Emilio Aicart ◽  
...  
Keyword(s):  
Experimental Approach ◽  
Compaction Process ◽  
Dioctadecyldimethylammonium Bromide

Experimental Determination of the Effective Resolution Limit in Thick Specimens at High Voltages

1975 ◽  
Vol 33 ◽  
pp. 664-665
Author(s):  
Mircea Fotino
Keyword(s):  
Experimental Approach ◽  
Chromatic Aberration ◽  
Resolving Power ◽  
Biological Research ◽  
Specimen Thickness ◽  
Resolution Limit ◽  
High Voltage Electron Microscopy ◽  
Voltage Electron ◽  
Resolution Level

The use of thick specimens (0.5 μm to 5.0 μm or more) is one of the most resourceful applications of high-voltage electron microscopy in biological research. However, the energy loss experienced by the electron beam in the specimen results in chromatic aberration and thus in a deterioration of the effective resolving power. This sets a limit to the maximum usable specimen thickness when investigating structures requiring a certain resolution level.An experimental approach is here described in which the deterioration of the resolving power as a function of specimen thickness is determined. In a manner similar to the Rayleigh criterion in which two image points are considered resolved at the resolution limit when their profiles overlap such that the minimum of one coincides with the maximum of the other, the resolution attainable in thick sections can be measured by the distance from minimum to maximum (or, equivalently, from 10% to 90% maximum) of the broadened profile of a well-defined step-like object placed on the specimen.

Malfunctional Reorganization in the Developing Limbo-Prefrontal System in Animals: Implications for Human Psychoses?

2001 ◽  
Vol 12 (1) ◽  
pp. 8-14
Author(s):  
Gertraud Teuchert-Noodt ◽  
Ralf R. Dawirs
Keyword(s):  
Prefrontal Cortex ◽  
Mental Disorders ◽  
Dentate Gyrus ◽  
Cognitive Functions ◽  
Experimental Approach ◽  
Regulatory Mechanisms ◽  
Hippocampal Dentate Gyrus ◽  
Non Invasive ◽  
Invasive Method ◽  
Activity Dependent

Abstract: Neuroplasticity research in connection with mental disorders has recently bridged the gap between basic neurobiology and applied neuropsychology. A non-invasive method in the gerbil (Meriones unguiculus) - the restricted versus enriched breading and the systemically applied single methamphetamine dose - offers an experimental approach to investigate psychoses. Acts of intervening affirm an activity dependent malfunctional reorganization in the prefrontal cortex and in the hippocampal dentate gyrus and reveal the dopamine position as being critical for the disruption of interactions between the areas concerned. From the extent of plasticity effects the probability and risk of psycho-cognitive development may be derived. Advance may be expected from insights into regulatory mechanisms of neurogenesis in the hippocampal dentate gyrus which is obviously to meet the necessary requirements to promote psycho-cognitive functions/malfunctions via the limbo-prefrontal circuit.

Fields of psychology: an experimental approach.

1943 ◽  
Vol 40 (1) ◽  
pp. 74-76
Author(s):  
Lyle H. Lanier
Keyword(s):  
Experimental Approach

Experimental approach and modeling of the compressive behaviour of two SiC grades

2000 ◽  
Vol 10 (PR9) ◽  
pp. Pr9-735-Pr9-740 ◽  
Author(s):  
P. Forquin ◽  
C. Denoual ◽  
C. E. Cottenot ◽  
L. Rota ◽  
F. Hild
Keyword(s):  
Experimental Approach ◽  
Compressive Behaviour

On the Reliability of the Use of Heparin Immobilized on Agarose for the Study of the Interactions among Heparin, Thrombin and Antithrombin

1982 ◽  
Vol 48 (01) ◽  
pp. 084-086
Author(s):  
Wayne W Fish ◽  
Ingemar Björk
Keyword(s):  
Experimental Approach ◽  
Antithrombin Iii ◽  
Chromogenic Substrate ◽  
Experimental Protocol ◽  
Appreciable Difference ◽  
Thrombin Inhibition ◽  
Highly Sensitive ◽  
Inhibition Of Thrombin

SummaryThe extent of inhibition of thrombin was re-examined as a consequence of the sequence of addition of thrombin and antithrombin III to a column of heparin immobilized on agarose. With the use of pure enzyme, pure inhibitor, and a highly sensitive chromogenic substrate, no appreciable difference in the extent of thrombin inhibition was observed between the two sequences of addition. These observations, together with a demonstrated sensitivity of the method to variations in experimental protocol, challenge the conclusions reached in an earlier work (Hatton and Regoeczi, Thromb. Res. 1977; 10:645) which utilized this experimental approach but which employed larger quantities of reactants and a less sensitive substrate.

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