Vibrational Analysis of Amino Acids and Short Peptides in Aqueous Media. V. The Effect of the Disulfide Bridge on the Structural Features of the Peptide Hormone Somatostatin-14

2009 ◽  
Vol 113 (38) ◽  
pp. 12796-12803 ◽  
Author(s):  
Belén Hernández ◽  
Claude Carelli ◽  
Yves-Marie Coïc ◽  
Joël De Coninck ◽  
Mahmoud Ghomi
Keyword(s):  
Amino Acids ◽  
Aqueous Media ◽  
Vibrational Analysis ◽  
Peptide Hormone ◽  
Disulfide Bridge ◽  
Structural Features ◽  
Short Peptides ◽  
Somatostatin 14

Vibrational Analysis of Amino Acids and Short Peptides in Hydrated Media. VI. Amino Acids with Positively Charged Side Chains:l-Lysine andl-Arginine

2010 ◽  
Vol 114 (2) ◽  
pp. 1077-1088 ◽  
Author(s):  
Belén Hernández ◽  
Fernando Pflüger ◽  
Najoua Derbel ◽  
Joël De Coninck ◽  
Mahmoud Ghomi
Keyword(s):  
Amino Acids ◽  
Vibrational Analysis ◽  
Short Peptides ◽  
Positively Charged

scholarly journals Entropy Effects in Intermolecular Associations of Crown-Ethers and Cyclodextrins with Amino Acids in Aqueous and in Non-Aqueous Media

Entropy ◽  
2021 ◽  
Vol 24 (1) ◽  
pp. 24
Author(s):  
Tatyana Usacheva ◽  
Irina Terekhova ◽  
Diana Alister ◽  
Mikhail Agafonov ◽  
Natalya Kuranova ◽  
...  
Keyword(s):  
Amino Acids ◽  
Crown Ethers ◽  
Driving Forces ◽  
Aqueous Media ◽  
Thermodynamic Characteristics ◽  
Structural Features ◽  
Organic Mixtures ◽  
Molecular Complexation ◽  
Thermodynamics Of Complex Formation ◽  
Entropy Effects

The analysis of the ratios of entropy and enthalpy characteristics and their contributions to the change in the Gibbs energy of intermolecular interactions of crown ethers and cyclodextrins with amino acids is carried out. Two different types of macrocycles were chosen for examination: crown ethers with a hydrophilic interior and cyclodextrins with a hydrophobic inner cavity and a hydrophilic exterior. The thermodynamics of complex formation of crown ethers and cyclodextrins with amino acids in water and aqueous-organic solvents of variable composition was examined. The contributions of the entropy solvation of complexes of 18-crown-6 with glycine, alanine, phenylalanine to the change in the entropy of complexation in water-ethanol and water-dimethyl sulfoxide solvents was calculated and analyzed. It was found that the ratios of the entropy and enthalpy solvation of the reagents for these systems have similar trends when moving from water to aqueous-organic mixtures. The relationship between the thermodynamic characteristics and structural features of the complexation processes between cyclodextrins and amino acids has been established. The thermodynamic enthalpy–entropy compensation effect was revealed, and its features for complexation of cyclodextrins and 18-crown-6 were considered. It was concluded that, based on the thermodynamic parameters of molecular complexation, one could judge the mode of the formation of complexes, the main driving forces of the interactions, and the degree of desolvation.

Vibrational Analysis of Amino Acids and Short Peptides in Hydrated Media. VIII. Amino Acids with Aromatic Side Chains:l-Phenylalanine,l-Tyrosine, andl-Tryptophan

2010 ◽  
Vol 114 (46) ◽  
pp. 15319-15330 ◽  
Author(s):  
Belén Hernández ◽  
Fernando Pflüger ◽  
Alain Adenier ◽  
Sergei G. Kruglik ◽  
Mahmoud Ghomi
Keyword(s):  
Amino Acids ◽  
Vibrational Analysis ◽  
Short Peptides

Vibrational Analysis of Amino Acids and Short Peptides in Hydrated Media. 3. Successive KL Repeats Induce Highly Stable β-Strands Capable of Forming Non-H-Bonded Aggregates

2008 ◽  
Vol 112 (4) ◽  
pp. 1282-1289 ◽  
Author(s):  
Guy Guiffo-Soh ◽  
Belén Hernández ◽  
Yves-Marie Coïc ◽  
Fatima-Zohra Boukhalfa-Heniche ◽  
Giulia Fadda ◽  
...  
Keyword(s):  
Amino Acids ◽  
Vibrational Analysis ◽  
Short Peptides

Vibrational Analysis of Amino Acids and Short Peptides in Hydrated Media. II. Role of KLLL Repeats To Induce Helical Conformations in Minimalist LK-Peptides

2007 ◽  
Vol 111 (43) ◽  
pp. 12563-12572 ◽  
Author(s):  
Guy Guiffo-Soh ◽  
Belén Hernández ◽  
Yves-Marie Coïc ◽  
Fatima-Zohra Boukhalfa-Heniche ◽  
Mahmoud Ghomi
Keyword(s):  
Amino Acids ◽  
Vibrational Analysis ◽  
Short Peptides

Vibrational Analysis of Amino Acids and Short Peptides in Hydrated Media. I. L-glycine and L-leucine

2007 ◽  
Vol 111 (6) ◽  
pp. 1470-1477 ◽  
Author(s):  
Najoua Derbel ◽  
Belén Hernández ◽  
Fernando Pflüger ◽  
Jean Liquier ◽  
Frédéric Geinguenaud ◽  
...  
Keyword(s):  
Amino Acids ◽  
Vibrational Analysis ◽  
Short Peptides

Traceable Peptidic Ligands that Target Ghrelin Receptors

2020 ◽  
Vol 21 (10) ◽  
pp. 955-964 ◽  
Author(s):  
Mengjie Liu ◽  
John Wade ◽  
Mohammed Akhter Hossain
Keyword(s):  
In Vivo Imaging ◽  
Peptide Hormone ◽  
Structural Features ◽  
Pharmacological Properties ◽  
Imaging Studies ◽  
Cognate Receptor ◽  
Ghrelin Receptors ◽  
Biochemical Research

: Ghrelin is a 28-amino acid octanoylated peptide hormone that is implicated in many physiological and pathophysiological processes. Specific visualization of ghrelin and its cognate receptor using traceable ligands is crucial in elucidating the localization, functions, and expression pattern of the peptide’s signaling pathway. Here 12 representative radio- and fluorescently-labeled peptide-based ligands are reviewed for in vitro and in vivo imaging studies. In particular, the focus is on their structural features, pharmacological properties, and applications in further biochemical research.

scholarly journals Alum Catalyzed Simple, Efficient, and Green Synthesis of 2-[3-Amino-5-methyl-5-(pyridin-3-yl)-1,5-dihydro-4H-1,2,4-triazol-4-yl]propanoic Acid Derivatives in Aqueous Media

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Harshita Sachdeva ◽  
Diksha Dwivedi ◽  
Rekha Saroj
Keyword(s):  
Amino Acids ◽  
Green Chemistry ◽  
Green Synthesis ◽  
Aqueous Media ◽  
Propanoic Acid ◽  
Ft Ir ◽  
C Nmr

Alum (KAl(SO4)2·12H2O) is an inexpensive, efficient, and nontoxic catalyst used for the synthesis of 2-[3-amino-5-methyl-5-(pyridin-3-yl)-1,5-dihydro-4H-1,2,4-triazol-4-yl]propanoic acid derivatives in aqueous media by the reaction of 3-acetyl pyridine(1), amino acids(2)/(6), and thiosemicarbazide(4)at 80°C. This methodology offers significant improvements for the synthesis of products with regards to the yield of products, simplicity in operation, and green aspects by avoiding toxic catalysts which uphold the motto of green chemistry. Synthesized compounds have been characterized by FT-IR,13C NMR, and1HNMR spectroscopy.

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