Unique Cellular Interaction of Silver Nanoparticles: Size-Dependent Generation of Reactive Oxygen Species

2008 ◽  
Vol 112 (43) ◽  
pp. 13608-13619 ◽  
Author(s):  
C. Carlson ◽  
S. M. Hussain ◽  
A. M. Schrand ◽  
L. K. Braydich-Stolle ◽  
K. L. Hess ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Silver Nanoparticles ◽  
Reactive Oxygen ◽  
Cellular Interaction ◽  
Oxygen Species ◽  
Size Dependent

Novel Tetrazoles against Acanthamoeba castellanii Belonging to the T4 Genotype

Chemotherapy ◽  
2021 ◽  
Author(s):  
Yassmin Isse Wehelie ◽  
Naveed Ahmed Khan ◽  
Itrat Fatima ◽  
Areeba Anwar ◽  
Kanwal Kanwal ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Silver Nanoparticles ◽  
Reactive Oxygen Species Generation ◽  
Acanthamoeba Castellanii ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Species Determination ◽  
One Pot ◽  
Tetrazole Derivatives

Background: Acanthamoeba castellanii is a pathogenic free-living amoeba responsible for blinding keratitis and fatal granulomatous amoebic encephalitis. However, treatments are not standardized but can involve the use of amidines, biguanides, and azoles. Objectives: The aim of this study was to synthesize a variety of synthetic tetrazole derivatives and test their activities against A. castellanii. Methods: A series of novel tetrazole compounds were synthesized by one-pot method and characterized by NMR and mass spectroscopy. These compounds were subjected to amoebicidal, and cytotoxicity assays against A. castellanii belonging to the T4 genotype and human keratinocyte skin cells respectively. Additionally, reactive oxygen species determination and electron microscopy studies were carried out. Furthermore, two of the seven compounds were conjugated with silver nanoparticles to study their antiamoebic potential. Results: A series of seven tetrazole derivatives were synthesized successfully. The selected tetrazoles showed anti-amoebic activities at 10µM concentration against A. castellanii in vitro. The compounds tested caused increased reactive oxygen species generation in A castellanii, and significant morphological damage to amoebal membranes. Moreover, conjugation of silver nanoparticles enhanced antiamoebic effects of two tetrazoles. Conclusions: The results showed that azole compounds hold promise in the development of new formulations of anti-Acanthamoebic agents.

Lifetime bioaccumulation of silver nanoparticles accelerates functional aging by inactivating antioxidant pathways, an effect reversed by pterostilbene

2021 ◽  
Author(s):  
Zi-Yu Chen ◽  
Yu-Chen Su ◽  
Fong-Yu Cheng ◽  
Shian-Jang Yan ◽  
Ying-Jan Wang
Keyword(s):  
Reactive Oxygen Species ◽  
Silver Nanoparticles ◽  
Adverse Effects ◽  
Signaling Pathways ◽  
Reactive Oxygen ◽  
Engineered Nanoparticles ◽  
Stress Signaling ◽  
Oxygen Species ◽  
Safety Concerns

Engineered nanoparticles raise safety concerns. Silver nanoparticles (AgNPs) exert acute and chronic adverse effects by inducing reactive oxygen species (ROS)-mediated stress signaling pathways. We investigated the mechanisms by which AgNPs...

Silver nanoparticles synthesized from Adenium obesum leaf extract induced DNA damage, apoptosis and autophagy via generation of reactive oxygen species

2016 ◽  
Vol 141 ◽  
pp. 158-169 ◽  
Author(s):  
Mohammad Abul Farah ◽  
Mohammad Ajmal Ali ◽  
Shen-Ming Chen ◽  
Ying Li ◽  
Fahad Mohammad Al-Hemaid ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Dna Damage ◽  
Silver Nanoparticles ◽  
Leaf Extract ◽  
Reactive Oxygen ◽  
Oxygen Species
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