Chemical Modification of a Tetrapyrrole-Type Photosensitizer: Tuning Application and Photochemical Action beyond the Singlet Oxygen Channel

2014 ◽  
Vol 118 (40) ◽  
pp. 11646-11658 ◽  
Author(s):  
Yasser M. Riyad ◽  
Sergej Naumov ◽  
Stanislaw Schastak ◽  
Jan Griebel ◽  
Axel Kahnt ◽  
...  
Keyword(s):  
Chemical Modification ◽  
Singlet Oxygen ◽  
Photochemical Action

scholarly journals Chemical modification of temoporfin – a second generation photosensitizer activated using upconverting nanoparticles for singlet oxygen generation

2014 ◽  
Vol 50 (81) ◽  
pp. 12150-12153 ◽  
Author(s):  
Q. Yu ◽  
E. M. Rodriguez ◽  
R. Naccache ◽  
P. Forgione ◽  
G. Lamoureux ◽  
...  
Keyword(s):  
Chemical Modification ◽  
Singlet Oxygen ◽  
Second Generation ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation

Photoconductivity in Vacuum Deposited Films of Silicon-Based Polymers

1996 ◽  
Vol 444 ◽  
Author(s):  
H. Okumoto ◽  
M. Shimomura ◽  
N. Minami ◽  
Y. Tanabe
Keyword(s):  
Charge Transfer ◽  
Chemical Modification ◽  
Electronic Transport ◽  
Hole Transport ◽  
Electron Acceptors ◽  
Oxygen Atmosphere ◽  
Dangling Bonds ◽  
Silicon Based ◽  
Deposited Films

AbstractSilicon-based polymers with σconjugated electrons have specific properties; photoreactivity for microlithography and photoconductivity for hole transport materials. To explore the possibility of combining these two properties to develop photoresists with electronic transport capability, photoconductivity of polysilanes is investigated in connection with their photoinduced chemical modification. Increase in photocurrent is observed accompanying photoreaction of poly(dimethylsilane) vacuum deposited films. This increase is found to be greatly enhanced in oxygen atmosphere. Such changes of photocurrent can be explained by charge transfer to electron acceptors from Si dangling bonds postulated to be formed during photoreaction.

Fluoroquinolone Antimicrobials: Singlet Oxygen, Superoxide and Phototoxicity

1998 ◽  
Vol 67 (4) ◽  
pp. 399 ◽  
Author(s):  
Lydia J. Martínez ◽  
Robert H. Sik ◽  
Colin F. Chignell
Keyword(s):  
Singlet Oxygen

A singlet oxygen sensor for photodynamic cancer therapy

1999 ◽  
Author(s):  
Philip B. Keating ◽  
Michael F. Hinds ◽  
Steven J. Davis
Keyword(s):  
Cancer Therapy ◽  
Singlet Oxygen ◽  
Oxygen Sensor ◽  
Photodynamic Cancer Therapy

Optical Properties of Photodynamic Therapy Drugs in Different Environments: The Paradigmatic Case of Temoporfin

2020 ◽  
Author(s):  
busenur Aslanoglu ◽  
Ilya Yakavets ◽  
Vladimir Zorin ◽  
Henri-Pierre Lassalle ◽  
Francesca Ingrosso ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Optical Properties ◽  
Photodynamic Therapy ◽  
Minimally Invasive ◽  
Visible Light ◽  
Cancer Treatment ◽  
Singlet Oxygen ◽  
Tumor Cells ◽  
Molecular Oxygen ◽  
Computational Tools

Computational tools have been used to study the photophysical and photochemical features of photosensitizers in photodynamic therapy (PDT) –a minimally invasive, less aggressive alternative for cancer treatment. PDT is mainly based by the activation of molecular oxygen through the action of a photoexcited sensitizer (photosensitizer). Temoporfin, widely known as mTHPC, is a second-generation photosensitizer, which produces the cytotoxic singlet oxygen when irradiated with visible light and hence destroys tumor cells. However, the bioavailability of the mostly hydrophobic photosensitizer, and hence its incorporation into the cells, is fundamental to achieve the desired effect on malignant tissues by PDT. In this study, we focus on the optical properties of the temoporfin chromophore in different environments –in <i>vacuo</i>, in solution, encapsulated in drug delivery agents, namely cyclodextrin, and interacting with a lipid bilayer.

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