The Boson Peak of Amyloid Fibrils: Probing the Softness of Protein Aggregates by Inelastic Neutron Scattering

2014 ◽  
Vol 118 (11) ◽  
pp. 2913-2923 ◽  
Author(s):  
G. Schirò ◽  
V. Vetri ◽  
C.B. Andersen ◽  
F. Natali ◽  
M.M. Koza ◽  
...  
2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
F. Migliardo ◽  
S. Magazù ◽  
M. A. Gonzalez ◽  
C. Mondelli

The biological relevance of trehalose, glycerol, and their mixtures in several anhydrobiotic and cryobiotic organisms has recently promoted both experimental and simulation studies. In addition, these systems are employed in different industrial fields, such as pharmaceutical and cosmetic industries, as additives in mixtures for cryopreservation and in several formulations. This review article shows an overview of Inelastic Neutron Scattering (INS) data, collected at different temperature values by the OSIRIS time-of-flight spectrometer at the ISIS Facility (Rutherford Appleton Laboratory, Oxford, UK) and by the IN4 and IN6 spectrometers at the Institut Laue Langevin (ILL, Grenoble, France), on trehalose/glycerol mixtures as a function of the glycerol content. The data analysis allows determining the Boson peak behavior and discussing the findings in terms of fragility in relation to the bioprotective action of trehalose and glycerol.


2000 ◽  
Vol 64 (3) ◽  
pp. 435-440 ◽  
Author(s):  
M. J. Harris ◽  
M. T. Dove ◽  
J. M. Parker

AbstractWe present the results of an inelastic neutron scattering study of a crystalline polymorph of SiO2 (α-quartz), and a number of silicate glasses (pure silica, SiO2, and three glasses in the alkali series (K,Li)2Si2O5). We demonstrate the presence of the Boson peak in the inelastic spectra of the crystalline and amorphous materials and argue that it arises simply from the dispersion characteristics of transverse acoustic modes. Furthermore, we investigate the role of the lower-energy floppy modes in the inelastic spectra, and show that they are controlled by chemical effects.


1992 ◽  
Vol 2 (10) ◽  
pp. 1929-1939 ◽  
Author(s):  
Mariette Barthes ◽  
Juegen Eckert ◽  
Susanna W. Johnson ◽  
Jacques Moret ◽  
Basil I. Swanson ◽  
...  

1992 ◽  
Vol 2 (2) ◽  
pp. 125-130 ◽  
Author(s):  
M. Quilichini ◽  
B. Hennion ◽  
G. Heger ◽  
S. Lefebvre ◽  
A. Quivy

1978 ◽  
Vol 39 (C6) ◽  
pp. C6-918-C6-919 ◽  
Author(s):  
B. H. Verbeek ◽  
C. Van Dijk ◽  
C. J. Nieuwenhuys ◽  
J. A. Mydosh

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