The Regulatory Implications of Hydroquinone for the Multifunctional Enzyme Dehaloperoxidase-Hemoglobin from Amphitrite ornata

2013 ◽  
Vol 117 (47) ◽  
pp. 14615-14624 ◽  
Author(s):  
Jing Zhao ◽  
Junjie Zhao ◽  
Stefan Franzen
Keyword(s):  
Multifunctional Enzyme ◽  
Amphitrite Ornata

Selective tuning of activity in a multifunctional enzyme as revealed in the F21W mutant of dehaloperoxidase B from Amphitrite ornata

2017 ◽  
Vol 23 (2) ◽  
pp. 209-219 ◽  
Author(s):  
Leiah M. Carey ◽  
Kyung Beom Kim ◽  
Nikolette L. McCombs ◽  
Paul Swartz ◽  
Cheal Kim ◽  
...  
Keyword(s):  
Multifunctional Enzyme ◽  
Amphitrite Ornata

scholarly journals Interaction of Azole-Based Environmental Pollutants with the Coelomic Hemoglobin from Amphitrite ornata: A Molecular Basis for Toxicity

Biochemistry ◽  
2017 ◽  
Vol 56 (17) ◽  
pp. 2294-2303 ◽  
Author(s):  
Nikolette L. McCombs ◽  
Tadeo Moreno-Chicano ◽  
Leiah M. Carey ◽  
Stefan Franzen ◽  
Michael A. Hough ◽  
...  
Keyword(s):  
Molecular Basis ◽  
Environmental Pollutants ◽  
Amphitrite Ornata

Molecular mechanism of the multifunctional enzyme l-δ-(α-aminoadipoyl)-l-cysteinyl-d-valine (ACV) synthetase

1995 ◽  
Vol 23 (4) ◽  
pp. 629S-629S ◽  
Author(s):  
CHIA-YANG SHIAU ◽  
MICHAEL F. BYFORD ◽  
JACK E. BALDWIN ◽  
CHRISTOPHER J. SCHOFIELD
Keyword(s):  
Molecular Mechanism ◽  
Multifunctional Enzyme

scholarly journals PPARα Activation Induces N ε-Lys-Acetylation of Rat Liver Peroxisomal Multifunctional Enzyme Type 1

Lipids ◽  
2013 ◽  
Vol 49 (2) ◽  
pp. 119-131 ◽  
Author(s):  
Miguel A. Contreras ◽  
Oscar Alzate ◽  
Avtar K. Singh ◽  
Inderjit Singh
Keyword(s):  
Rat Liver ◽  
Multifunctional Enzyme

scholarly journals Corrigendum to “Interaction between goniothalamin and peroxisomal multifunctional enzyme type 2 triggering endoplasmic reticulum stress” [Heliyon 6 (10) (October 2020) e05200]

Heliyon ◽  
2021 ◽  
Vol 7 (2) ◽  
pp. e05907
Author(s):  
Thanet Sophonnithiprasert ◽  
Ornjira Aruksakunwong ◽  
Etsu Tashiro ◽  
Yasumitsu Kondoh ◽  
Makoto Muroi ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Multifunctional Enzyme

Crystallization and characterization of the dehydrogenase domain from rat peroxisomal multifunctional enzyme type 1

2002 ◽  
Vol 58 (4) ◽  
pp. 690-693 ◽  
Author(s):  
Jukka P. Taskinen ◽  
Tiila-Riikka Kiema ◽  
Kari T. Koivuranta ◽  
Rik K. Wierenga ◽  
J. Kalervo Hiltunen
Keyword(s):  
Multifunctional Enzyme

Peroxisomal multifunctional enzyme type 2 from the fruitfly: dehydrogenase and hydratase act as separate entities, as revealed by structure and kinetics

2011 ◽  
Vol 435 (3) ◽  
pp. 771-781 ◽  
Author(s):  
Tatu J. K. Haataja ◽  
M. Kristian Koski ◽  
J. Kalervo Hiltunen ◽  
Tuomo Glumoff
Keyword(s):  
Crystal Structure ◽  
Saccharomyces Cerevisiae ◽  
Drosophila Melanogaster ◽  
Structural Features ◽  
Full Length ◽  
Multifunctional Enzyme ◽  
Domain Composition ◽  
Substrate Channelling

All of the peroxisomal β-oxidation pathways characterized thus far house at least one MFE (multifunctional enzyme) catalysing two out of four reactions of the spiral. MFE type 2 proteins from various species display great variation in domain composition and predicted substrate preference. The gene CG3415 encodes for Drosophila melanogaster MFE-2 (DmMFE-2), complements the Saccharomyces cerevisiae MFE-2 deletion strain, and the recombinant protein displays both MFE-2 enzymatic activities in vitro. The resolved crystal structure is the first one for a full-length MFE-2 revealing the assembly of domains, and the data can also be transferred to structure–function studies for other MFE-2 proteins. The structure explains the necessity of dimerization. The lack of substrate channelling is proposed based on both the structural features, as well as by the fact that hydration and dehydrogenation activities of MFE-2, if produced as separate enzymes, are equally efficient in catalysis as the full-length MFE-2.

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