Chitosan-Modified Stable Colloidal Gold Nanostars for the Photothermolysis of Cancer Cells

2013 ◽  
Vol 117 (5) ◽  
pp. 2396-2410 ◽  
Author(s):  
Ivan Baginskiy ◽  
Tsung-Ching Lai ◽  
Liang-Chien Cheng ◽  
Yung-Chieh Chan ◽  
Kuang-Yu Yang ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Colloidal Gold ◽  
Gold Nanostars

Gold nanostars as a colloidal substrate for in-solution SERS measurements using a handheld Raman spectrometer

The Analyst ◽  
2020 ◽  
Vol 145 (4) ◽  
pp. 1396-1407 ◽  
Author(s):  
Ahmed Y. F. Mahmoud ◽  
Casey J. Rusin ◽  
Mark T. McDermott
Keyword(s):  
Colloidal Gold ◽  
Raman Spectrometer ◽  
Gold Nanostars

Colloidal gold nanostars for rapid and in-solution SERS measurements of methimazole in urine using a handheld Raman spectrometer.

Facile preparation of albumin-stabilized gold nanostars for the targeted photothermal ablation of cancer cells

2015 ◽  
Vol 3 (28) ◽  
pp. 5806-5814 ◽  
Author(s):  
Jingchao Li ◽  
Rong Cai ◽  
Naoki Kawazoe ◽  
Guoping Chen
Keyword(s):  
Cancer Cells ◽  
Photothermal Conversion ◽  
Gold Nanostars ◽  
Photothermal Ablation ◽  
Facile Preparation

BSA–FA conjugation was used as a stabilizer to synthesize gold nanostars (BSA–FA–AuNSs). The prepared BSA–FA–AuNSs should have a great potential as photothermal conversion agents for the receptor-mediated treatment of cancer cells.

scholarly journals Effects of cordycepin, gold nanostar and their combination on endometrial cancer cells

2019 ◽  
Author(s):  
Pedro Fong ◽  
Chicheng Cheong ◽  
Kawai Mak ◽  
Chicheng Lei ◽  
Manhei Ho ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cancer Cells ◽  
Light Exposure ◽  
Particle Size Analysis ◽  
Size Analysis ◽  
Survival Fraction ◽  
Gold Nanostars ◽  
Anti Cancer ◽  
New Treatments ◽  
Inhibit Cell Proliferation

Abstract Background: The incidence rate of endometrial cancer has increased significantly in the past two decades. The current chemotherapy of endometrial cancer can cause intolerable side effects. Recently, both cordycepin and gold nanostars have demonstrated the ability to inhibit the growth and differentiation of cancers. The aim of this study was to investigate the anti-endometrial cancer effects of cordycepin, gold nanostars and the combination of two. Methods: The gold nanostars were made by seed-mediated reduction, and their morphology was confirmed by laser particle size analysis, spectrophotometry and electron microscopy. MTT cytotoxicity assays, clonogenic assays and flow cytometry were employed to evaluate the inhibition rate, survival fraction and apoptosis in HEC-1A cells under different concentrations of cordycepin, Au NS and their combination. Results: This study revealed that both cordycepin and Au NS with 808 nm light exposure could inhibit cell proliferation, cause cell apoptosis, and inhibit clone ability of endometrial cancer cells. The combined Au NS-cordycepin solution produced greater anti-cancer effects than each treatment alone. Conclusion: This study supports further investigations into Au NS-cordycepin in the development of new treatments for endometrial cancer.

scholarly journals Intercellular Trafficking of Gold Nanostars in Uveal Melanoma Cells for Plasmonic Photothermal Therapy

Nanomaterials ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 590 ◽  
Author(s):  
Rubén Ahijado-Guzmán ◽  
Natalia Sánchez-Arribas ◽  
María Martínez-Negro ◽  
Guillermo González-Rubio ◽  
María Santiago-Varela ◽  
...  
Keyword(s):  
Cell Division ◽  
Cancer Cells ◽  
Uveal Melanoma ◽  
Near Infrared ◽  
Melanoma Cells ◽  
Photothermal Effect ◽  
Plasmonic Nanostructures ◽  
Electromagnetic Spectrum ◽  
Pulse Laser Irradiation ◽  
Gold Nanostars

Efficient plasmonic photothermal therapies (PPTTs) using non-harmful pulse laser irradiation at the near-infrared (NIR) are a highly sought goal in nanomedicine. These therapies rely on the use of plasmonic nanostructures to kill cancer cells while minimizing the applied laser power density. Cancer cells have an unsettled capacity to uptake, retain, release, and re-uptake gold nanoparticles, thus offering enormous versatility for research. In this work, we have studied such cell capabilities for nanoparticle trafficking and its impact on the effect of photothermal treatments. As our model system, we chose uveal (eye) melanoma cells, since laser-assisted eye surgery is routinely used to treat glaucoma and cataracts, or vision correction in refractive surgery. As nanostructure, we selected gold nanostars (Au NSs) due to their high photothermal efficiency at the near-infrared (NIR) region of the electromagnetic spectrum. We first investigated the photothermal effect on the basis of the dilution of Au NSs induced by cell division. Using this approach, we obtained high PPTT efficiency after several cell division cycles at an initial low Au NS concentration (pM regime). Subsequently, we evaluated the photothermal effect on account of cell division upon mixing Au NS-loaded and non-loaded cells. Upon such mixing, we observed trafficking of Au NSs between loaded and non-loaded cells, thus achieving effective PPTT after several division cycles under low irradiation conditions (below the maximum permissible exposure threshold of skin). Our study reveals the ability of uveal melanoma cells to release and re-uptake Au NSs that maintain their plasmonic photothermal properties throughout several cell division cycles and re-uptake. This approach may be readily extrapolated to real tissue and even to treat in situ the eye tumor itself. We believe that our method can potentially be used as co-therapy to disperse plasmonic gold nanostructures across affected tissues, thus increasing the effectiveness of classic PPTT.

Tuning Size and Sensing Properties in Colloidal Gold Nanostars

Langmuir ◽  
2010 ◽  
Vol 26 (18) ◽  
pp. 14943-14950 ◽  
Author(s):  
Silvia Barbosa ◽  
Amit Agrawal ◽  
Laura Rodríguez-Lorenzo ◽  
Isabel Pastoriza-Santos ◽  
Ramón A. Alvarez-Puebla ◽  
...  
Keyword(s):  
Colloidal Gold ◽  
Sensing Properties ◽  
Gold Nanostars
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