The Role of Amino Acid Sequence in the Self-Association of Therapeutic Monoclonal Antibodies: Insights from Coarse-Grained Modeling

2013 ◽  
Vol 117 (5) ◽  
pp. 1269-1279 ◽  
Author(s):  
Anuj Chaudhri ◽  
Isidro E. Zarraga ◽  
Sandeep Yadav ◽  
Thomas W. Patapoff ◽  
Steven J. Shire ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Amino Acid ◽  
Amino Acid Sequence ◽  
The Self ◽  
Coarse Grained ◽  
Self Association ◽  
Therapeutic Monoclonal Antibodies

Coarse-Grained Modeling of the Self-Association of Therapeutic Monoclonal Antibodies

2012 ◽  
Vol 116 (28) ◽  
pp. 8045-8057 ◽  
Author(s):  
Anuj Chaudhri ◽  
Isidro E. Zarraga ◽  
Tim J. Kamerzell ◽  
J. Paul Brandt ◽  
Thomas W. Patapoff ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
The Self ◽  
Coarse Grained ◽  
Self Association ◽  
Therapeutic Monoclonal Antibodies

scholarly journals Unravelling the role of amino acid sequence order in the assembly and function of the amyloid-β core

2019 ◽  
Vol 55 (59) ◽  
pp. 8595-8598 ◽  
Author(s):  
Santu Bera ◽  
Elad Arad ◽  
Lee Schnaider ◽  
Shira Shaham-Niv ◽  
Valeria Castelletto ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Sequence ◽  
Self Assembly ◽  
Amyloid Β ◽  
The Self ◽  
Biological Functions ◽  
The Core ◽  
Recognition Motif ◽  
And Function

Here we report the influence of amino acid sequence order on the self-assembly and biological functions of the core recognition motif of Amyloid β.

Shark Myelin Basic Protein: Amino Acid Sequence, Secondary Structure, and Self-Association

1990 ◽  
Vol 55 (3) ◽  
pp. 950-955 ◽  
Author(s):  
Trudy J. Milne ◽  
Annette R. Atkins ◽  
Juanita A. Warren ◽  
Wendy P. Auton ◽  
Ross Smith
Keyword(s):  
Amino Acid ◽  
Secondary Structure ◽  
Amino Acid Sequence ◽  
Myelin Basic Protein ◽  
Basic Protein ◽  
Protein Amino Acid ◽  
Protein Amino Acid Sequence ◽  
Self Association

Functional role of carbohydrate residues in human immunoglobulin G and therapeutic monoclonal antibodies

2016 ◽  
Vol 81 (8) ◽  
pp. 835-857 ◽  
Author(s):  
Y. L. Dorokhov ◽  
E. V. Sheshukova ◽  
E. N. Kosobokova ◽  
A. V. Shindyapina ◽  
V. S. Kosorukov ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Immunoglobulin G ◽  
Functional Role ◽  
Human Immunoglobulin ◽  
Human Immunoglobulin G ◽  
Therapeutic Monoclonal Antibodies

scholarly journals Purification, characterization, gene sequence, and significance of a bacterioferritin from Mycobacterium leprae.

1994 ◽  
Vol 180 (1) ◽  
pp. 319-327 ◽  
Author(s):  
M C Pessolani ◽  
D R Smith ◽  
B Rivoire ◽  
J McCormick ◽  
S A Hefta ◽  
...  
Keyword(s):  
Amino Acid ◽  
Membrane Protein ◽  
Amino Acid Sequence ◽  
Mycobacterium Leprae ◽  
Native Molecular Mass ◽  
Molecular Features ◽  
Ferroxidase Center ◽  
Considerable Homology

The study of tissue-derived Mycobacterium leprae provides insights to the immunopathology of leprosy and helps identify broad molecular features necessary for mycobacterial parasitism. A major membrane protein (MMP-II) of in vivo-derived M. leprae previously recognized (Hunter, S.W., B. Rivoire, V. Mehra, B.R. Bloom, and P.J. Brennan. 1990. J. Biol. Chem. 265:14065) was purified from extracts of the organism and partial amino acid sequence obtained. This information allowed recognition, within one of the cosmids that encompass the entire M. leprae genome, of a complete gene, bfr, encoding a protein of subunit size 18.2 kD. The amino acid sequence deduced from the major membrane protein II (MMP-II) gene revealed considerable homology to several bacterioferritins. Analysis of the native protein demonstrated the iron content, absorption spectrum, and large native molecular mass (380 kD) of several known bacterioferritins. The ferroxidase-center residues typical of ferritins were conserved in the M. leprae product. Oligonucleotides derived from the amino acid sequence of M. leprae bacterioferritin enabled amplification of much of the MMP-II gene and the detection of homologous sequences in Mycobacterium paratuberculosis, Mycobacterium avium, Mycobacterium tuberculosis, Mycobacterium intracellulare, and Mycobacterium scrofulaceum. The role of this iron-rich protein in the virulence of M. leprae is discussed.

scholarly journals Amino acid sequence and immunological characterization with monoclonal antibodies of two toxins from the venom of the scorpion Centruroides noxius Hoffmann

1992 ◽  
Vol 204 (1) ◽  
pp. 281-292 ◽  
Author(s):  
Fernando ZAMUDIO ◽  
Rafael SAAVEDRA ◽  
Brian Michael MARTIN ◽  
Georgina GURROLA-BRIONES ◽  
Pascal HERION ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Amino Acid ◽  
Amino Acid Sequence ◽  
Immunological Characterization ◽  
Centruroides Noxius
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