Heterogeneous Asymmetric Hydrogenation of Activated Ketones: Mechanistic Insight into the Role of Alcohol Products by in Situ Modulation-Excitation IR Spectroscopy

2012 ◽  
Vol 116 (6) ◽  
pp. 4182-4188 ◽  
Author(s):  
Nobutaka Maeda ◽  
Shogo Sano ◽  
Tamas Mallat ◽  
Konrad Hungerbühler ◽  
Alfons Baiker
Keyword(s):  
Ir Spectroscopy ◽  
Asymmetric Hydrogenation ◽  
Mechanistic Insight ◽  
Insight Into ◽  
Modulation Excitation

scholarly journals Insight into the Role of Cerium (III) Addition to a MgAl-LDH Coating on AA6082

2021 ◽  
Vol 11 (17) ◽  
pp. 8252
Author(s):  
Michele Fedel ◽  
Michele Zampiccoli
Keyword(s):  
Electrochemical Impedance ◽  
Synthesis Method ◽  
Aluminum Surface ◽  
Precipitation Mechanism ◽  
Platelet Morphology ◽  
Mechanistic Insight ◽  
Saline Solutions ◽  
Insight Into

In this work, Ce doped MgAl-LDHs layers have been developed through an in-situ synthesis method on 6082 aluminum surface. The aim was to gain mechanistic insight into the role of Ce(III) as an active corrosion inhibitor embedded in the LDHs layer. The development of the LDH structure was verified by checking the presence of the characteristic XRD peaks, the platelet morphology (evaluated by SEM-EDXS) and the functional groups (by FTIR-ATR analyses). The same techniques were employed to assess the effect of a prolonged immersion time in 0.1 NaCl on the Ce doped MgAl-LDH coatings. Electrochemical impedance spectroscopy (EIS) was employed to monitor the evolution of the electrochemical properties of the coatings during prolonged immersion in saline solutions. The findings suggest a crystallization/dissolution/precipitation mechanism which implies: (i) the formation of crystalline cerium compounds, such as Ce(OH)3, in the LDH structure during the synthesis; (ii) the dissolution upon exposure to the NaCl solution, thus leading to cerium ions release; (iii) the precipitation of amorphous Ce oxides/hydroxides at the cathodic sites when the metal starts to corrode; (iv), the consequent mitigation of the electrochemical activity of the metal and, thus, the reduction of the extent of corrosion.

scholarly journals In situ synthesis of methane using Ag–GDC composite electrodes in a tubular solid oxide electrolytic cell: new insight into the role of oxide ion removal

2021 ◽  
Vol 5 (7) ◽  
pp. 2055-2064
Author(s):  
Saheli Biswas ◽  
Aniruddha P. Kulkarni ◽  
Daniel Fini ◽  
Sarbjit Giddey ◽  
Sankar Bhattacharya
Keyword(s):  
Electrolytic Cell ◽  
Composite Electrodes ◽  
Ion Removal ◽  
Single Temperature ◽  
Methanation Catalyst ◽  
Oxide Ion ◽  
Insight Into ◽  
Electrochemical Phenomenon

In situ synthesis of methane in a single-temperature zone SOEC in the absence of any methanation catalyst is a completely electrochemical phenomenon governed by the thermodynamic equilibrium of various reactions.

A Pictorial Tracking of Basal Plane Dislocations in SiC Epitaxy

2010 ◽  
Vol 645-648 ◽  
pp. 271-276 ◽  
Author(s):  
Robert E. Stahlbush ◽  
Rachael L. Myers-Ward ◽  
Brenda L. VanMil ◽  
D. Kurt Gaskill ◽  
Charles R. Eddy
Keyword(s):  
Epitaxial Growth ◽  
Basal Plane ◽  
Reduction Process ◽  
Epitaxial Layers ◽  
In Situ Growth ◽  
Half Loop ◽  
Insight Into

The recently developed technique of UVPL imaging has been used to track the path of basal plane dislocations (BPDs) in SiC epitaxial layers. The glide of BPDs during epitaxial growth has been observed and the role of this glide in forming half-loop arrays has been examined. The ability to track the path of BPDs through the epitaxy has made it possible to develop a BPD reduction process for epitaxy grown on 8° offcut wafers, which uses an in situ growth interrupt and has achieved a BPD reduction of > 98%. The images also provide insight into the strong BPD reduction that typically occurs in epitaxy grown on 4° offcut wafers.

scholarly journals KH-type splicing regulatory protein is a new component of chromatoid body

Reproduction ◽  
2017 ◽  
Vol 154 (6) ◽  
pp. 723-733 ◽  
Author(s):  
Huijuan Zhang ◽  
Guishuan Wang ◽  
Lin Liu ◽  
Xiaolin Liang ◽  
Yu Lin ◽  
...  
Keyword(s):  
Gene Expression ◽  
Germ Cell ◽  
Knockout Mice ◽  
Binding Protein ◽  
Regulatory Protein ◽  
Somatic Cells ◽  
Chromatoid Body ◽  
Mechanistic Insight ◽  
Insight Into

The chromatoid body (CB) is a specific cloud-like structure in the cytoplasm of haploid spermatids. Recent findings indicate that CB is identified as a male germ cell-specific RNA storage and processing center, but its function has remained elusive for decades. In somatic cells, KH-type splicing regulatory protein (KSRP) is involved in regulating gene expression and maturation of select microRNAs (miRNAs). However, the function of KSRP in spermatogenesis remains unclear. In this study, we showed that KSRP partly localizes in CB, as a component of CB. KSRP interacts with proteins (mouse VASA homolog (MVH), polyadenylate-binding protein 1 (PABP1) and polyadenylate-binding protein 2 (PABP2)), mRNAs (Tnp2 and Odf1) and microRNAs (microRNA-182) in mouse CB. Moreover, KSRP may regulate the integrity of CB via DDX5-miRNA-182 pathway. In addition, we found abnormal expressions of CB component in testes of Ksrp-knockout mice and of patients with hypospermatogenesis. Thus, our results provide mechanistic insight into the role of KSRP in spermatogenesis.

Mechanistic insight into the role of metformin in Alzheimer's disease

Life Sciences ◽  
2022 ◽  
pp. 120299
Author(s):  
Mehdi Sanati ◽  
Samaneh Aminyavari ◽  
Amir R. Afshari ◽  
Amirhossein Sahebkar
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mechanistic Insight ◽  
Insight Into

scholarly journals Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Brianna J. Klein ◽  
Suk Min Jang ◽  
Catherine Lachance ◽  
Wenyi Mi ◽  
Jie Lyu ◽  
...  
Keyword(s):  
Posttranslational Modification ◽  
Memory Impairment ◽  
Target Genes ◽  
Epigenetic Mark ◽  
Mechanistic Insight ◽  
Genomic Analyses ◽  
Insight Into

Abstract Acetylation of histone H3K23 has emerged as an essential posttranslational modification associated with cancer and learning and memory impairment, yet our understanding of this epigenetic mark remains insufficient. Here, we identify the native MORF complex as a histone H3K23-specific acetyltransferase and elucidate its mechanism of action. The acetyltransferase function of the catalytic MORF subunit is positively regulated by the DPF domain of MORF (MORFDPF). The crystal structure of MORFDPF in complex with crotonylated H3K14 peptide provides mechanistic insight into selectivity of this epigenetic reader and its ability to recognize both histone and DNA. ChIP data reveal the role of MORFDPF in MORF-dependent H3K23 acetylation of target genes. Mass spectrometry, biochemical and genomic analyses show co-existence of the H3K23ac and H3K14ac modifications in vitro and co-occupancy of the MORF complex, H3K23ac, and H3K14ac at specific loci in vivo. Our findings suggest a model in which interaction of MORFDPF with acylated H3K14 promotes acetylation of H3K23 by the native MORF complex to activate transcription.

Sign in / Sign up

Export Citation Format

Share Document