Electrode-Supported Biomembrane for Examining Electron-Transfer and Ion-Transfer Reactions of Encapsulated Low Molecular Weight Biological Molecules

2011 ◽  
Vol 115 (5) ◽  
pp. 2100-2113 ◽  
Author(s):  
Wei Wei Yao ◽  
Charmaine Lau ◽  
Yanlan Hui ◽  
Hwee Ling Poh ◽  
Richard D. Webster
Keyword(s):  
Molecular Weight ◽  
Electron Transfer ◽  
Biological Molecules ◽  
Transfer Reactions ◽  
Low Molecular Weight ◽  
Ion Transfer

2-Aminopyridine - An unsung hero in drug discovery

2021 ◽  
Author(s):  
nishanth ramdas ◽  
Kaushik Chanda
Keyword(s):  
Molecular Weight ◽  
Drug Discovery ◽  
Biological Molecules ◽  
Low Molecular Weight

Abstract 2-aminopyridine is a simple, low molecular weight and perfectly functionalized moiety known for the synthesis of diverse biological molecules. Many pharma stations across the globe aim to synthesize and...

Intermolecular Electron Transfer in Low-Molecular-Weight Polyaniline Models Associating on Protonation by Amphiphilic Acid in Organic Solvent

2001 ◽  
Vol 34 (16) ◽  
pp. 5480-5486 ◽  
Author(s):  
Natalya A. Lokshin ◽  
Olga A. Pyshkina ◽  
Vladimir B. Golubev ◽  
Vladimir G. Sergeyev ◽  
Alexander B. Zezin ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Electron Transfer ◽  
Organic Solvent ◽  
Low Molecular Weight ◽  
Intermolecular Electron Transfer

scholarly journals Acceptor range of endo-β- N -acetylglucosaminidase mutant endo-CC N180H: from monosaccharide to antibody

2018 ◽  
Vol 5 (5) ◽  
pp. 171521 ◽  
Author(s):  
Shino Manabe ◽  
Yoshiki Yamaguchi ◽  
Junpei Abe ◽  
Kana Matsumoto ◽  
Yukishige Ito
Keyword(s):  
Mass Spectrometry ◽  
Molecular Weight ◽  
Transfer Reactions ◽  
Low Molecular Weight ◽  
Acceptor Molecules

The endo-β- N -acetylglucosaminidase mutant endo-CC N180H transfers glycan from sialylglycopeptide (SGP) to various acceptors. The scope and limitations of low-molecular-weight acceptors were investigated. Several homogeneous glycan-containing compounds, especially those with potentially useful labels or functional moieties, and possible reagents in glycoscience were synthesized. The 1,3-diol structure is important in acceptor molecules in glycan transfer reactions mediated by endo-CC N180H as well as by endo-M-N175Q. Glycan remodelling of antibodies was explored using core-fucose-deficient anti-CCR4 antibody with SGP and endo-CC N180H. Homogeneity of the glycan in the antibody was confirmed by mass spectrometry without glycan cleavage.

scholarly journals Critical Minireview: The Fate of tRNACys during Oxidative Stress in Bacillus subtilis

2016 ◽  
Author(s):  
Juan Campos Guillen ◽  
George H. Jones ◽  
Carlos Saldaña Gutierrez ◽  
José Luis Hernández Flores ◽  
Julio Alfonso Cruz Medina ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Molecular Weight ◽  
Bacillus Subtilis ◽  
Essential Gene ◽  
Biological Molecules ◽  
Low Molecular Weight ◽  
Oxygen Species ◽  
Bacterial Response ◽  
Protein Thiols ◽  
And Oxidative Stress

Oxidative stress occurs when cells are exposed to elevated levels of reactive oxygen species that could damage biological molecules. One bacterial response to oxidative stress involves disulfide bond formation either between protein thiols or between protein thiols and low-molecular-weight thiols. Bacillithiol was recently identified as a major low-molecular-weight thiol in Bacillus subtilis and related Firmicutes. Four genes (bshA, bshB1, bshB2 and bshC) are involved in bacillithiol biosynthesis. The bshA and bshB1 genes are part of a seven-gene operon (ypjD), which includes the essential gene cca, encoding CCA-tRNA nucleotidyltransferase. The inclusion of cca in the operon containing bacillithiol biosynthetic genes suggests that the integrity of the 3’ terminus of tRNAs may also be important in oxidative stress. Addition of the 3´ terminal CCA sequence by CCA-tRNA nucleotidyltransferase to give a mature tRNA and functional molecules ready for aminoacylation plays an essential role during translation and expression of the genetic code. Any defects in these processes, for example, the accumulation of shorter and defective tRNAs under oxidative stress, could exert a deleterious effect on cells. This review summarizes the physiological link between tRNACys regulation and oxidative stress in Bacillus.

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