Cytosensor Constructed with a Biomimetic Fibronectin-Functionalized Carbon Nanotubes on Glassy Carbon Heated Electrode

2010 ◽  
Vol 114 (45) ◽  
pp. 19503-19508 ◽  
Author(s):  
Xue Zhong ◽  
Guang-Sheng Qian ◽  
Jing-Juan Xu ◽  
Hong-Yuan Chen
Keyword(s):  
Carbon Nanotubes ◽  
Glassy Carbon ◽  
Functionalized Carbon Nanotubes ◽  
Heated Electrode

scholarly journals Differential pulse adsorptive stripping voltammetric determination of methotrexate using a functionalized carbon nanotubes-modified glassy carbon electrode

2013 ◽  
Vol 11 (11) ◽  
pp. 1837-1843 ◽  
Author(s):  
Geiser Oliveira ◽  
Bruno Janegitz ◽  
Valtencir Zucolotto ◽  
Orlando Fatibello-Filho
Keyword(s):  
Carbon Nanotubes ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
High Performance ◽  
Comparative Method ◽  
Differential Pulse ◽  
Carbon Electrode ◽  
Experimental Conditions ◽  
Functionalized Carbon Nanotubes

AbstractA glassy carbon electrode (GC) containing multiwalled functionalized carbon nanotubes (MWCNTs) immobilized within a dihexadecylhydrogenphosphate film (DHP) is proposed as a nanostructured platform for determination of methotrexate (MTX) concentration (a drug used in cancer treatment) using differential pulse adsorptive stripping voltammetry (DPAdSV). The voltammograms for a MTX solution using MWCNTs-DHP/GC electrode presented an oxidation peak potential at 0.98 V vs. Ag/AgCl (3.0 mol L−1 KCl) in a 0.1 mol L−1 sulphuric acid. The apparent heterogeneous electron transfer rate constant of 0.46 s−1 was calculated. The recovery area of 2.62×10−9 mol cm2 was also obtained. Under the optimal experimental conditions, the analytical curve was linear in the MTX concentration range from 5.0×10−8 to 5.0×10−6 mol L−1, with a detection limit of 3.3×10−8 mol L−1. The MWCNTs-DHP/GC electrode can be easily prepared and was applied for the determination of MTX in pharmaceutical formulations, with results similar to those obtained using a high-performance liquid chromatography comparative method.

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