Comment on “Atmospheric Chemistry of Linear Perfluorinated Aldehydes:  Dissociation Kinetics of CnF2n+1CO Radicals”

2008 ◽  
Vol 112 (3) ◽  
pp. 576-577 ◽  
Author(s):  
T. J. Wallington ◽  
S. A. Mabury ◽  
M. D. Hurley ◽  
M. P. Sulbaek Andersen ◽  
O. J. Nielsen ◽  
...  
Keyword(s):  
Atmospheric Chemistry ◽  
Dissociation Kinetics ◽  
Kinetics Of

Accelerating water dissociation kinetics of Ni3N by tuning interfacial orbital coupling

Nano Research ◽  
2021 ◽  
Author(s):  
Yishang Wu ◽  
Yufang Xie ◽  
Shuwen Niu ◽  
Yipeng Zang ◽  
Jinyan Cai ◽  
...  
Keyword(s):  
Water Dissociation ◽  
Dissociation Kinetics ◽  
Kinetics Of

scholarly journals High-resolution view of HIV-1 reverse transcriptase initiation complexes and inhibition by NNRTI drugs

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Betty Ha ◽  
Kevin P. Larsen ◽  
Jingji Zhang ◽  
Ziao Fu ◽  
Elizabeth Montabana ◽  
...  
Keyword(s):  
Reverse Transcriptase ◽  
Viral Entry ◽  
Reverse Transcription ◽  
Molecular Mechanisms ◽  
Dissociation Kinetics ◽  
Structural Mechanism ◽  
Medium Resolution ◽  
Kinetics Of ◽  
Hiv 1

AbstractReverse transcription of the HIV-1 viral RNA genome (vRNA) is an integral step in virus replication. Upon viral entry, HIV-1 reverse transcriptase (RT) initiates from a host tRNALys3 primer bound to the vRNA genome and is the target of key antivirals, such as non-nucleoside reverse transcriptase inhibitors (NNRTIs). Initiation proceeds slowly with discrete pausing events along the vRNA template. Despite prior medium-resolution structural characterization of reverse transcriptase initiation complexes (RTICs), higher-resolution structures of the RTIC are needed to understand the molecular mechanisms that underlie initiation. Here we report cryo-EM structures of the core RTIC, RTIC–nevirapine, and RTIC–efavirenz complexes at 2.8, 3.1, and 2.9 Å, respectively. In combination with biochemical studies, these data suggest a basis for rapid dissociation kinetics of RT from the vRNA–tRNALys3 initiation complex and reveal a specific structural mechanism of nucleic acid conformational stabilization during initiation. Finally, our results show that NNRTIs inhibit the RTIC and exacerbate discrete pausing during early reverse transcription.

Effects of Charcoal on Dissociation Kinetics of Nuclear and Cytosolic Steroid-Receptor Complexes from Hen Oviduct

1990 ◽  
Vol 10 (3-4) ◽  
pp. 137-148
Author(s):  
Adele J. Wolfson ◽  
Michele R. Hutchison ◽  
Janey S. Andrews ◽  
Kathleen J. Merriam
Keyword(s):  
Steroid Receptor ◽  
Dissociation Kinetics ◽  
Receptor Complexes ◽  
Kinetics Of

Atmospheric chemistry of trans-CF3CHCHCl: Kinetics of the gas-phase reactions with Cl atoms, OH radicals, and O3

2008 ◽  
Vol 199 (1) ◽  
pp. 92-97 ◽  
Author(s):  
M.P. Sulbaek Andersen ◽  
E.J.K. Nilsson ◽  
O.J. Nielsen ◽  
M.S. Johnson ◽  
M.D. Hurley ◽  
...  
Keyword(s):  
Gas Phase ◽  
Atmospheric Chemistry ◽  
Oh Radicals ◽  
Gas Phase Reactions ◽  
Kinetics Of ◽  
Cl Atoms
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