Design of Gd(III)-Based Magnetic Resonance Imaging Contrast Agents:  Static and Transient Zero-Field Splitting Contributions to the Electronic Relaxation and Their Impact on Relaxivity

2007 ◽  
Vol 111 (4) ◽  
pp. 832-840 ◽  
Author(s):  
Meriem Benmelouka ◽  
Alain Borel ◽  
Loick Moriggi ◽  
Lothar Helm ◽  
André E Merbach
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Electronic Relaxation ◽  
Zero Field ◽  
Resonance Imaging ◽  
Zero Field Splitting ◽  
Field Splitting ◽  
Magnetic Resonance Imaging Contrast

2D Gadolinium Oxide Nanoplates as T 1 Magnetic Resonance Imaging Contrast Agents

2021 ◽  
pp. 2001780
Author(s):  
Gary Stinnett ◽  
Nasim Taheri ◽  
Jake Villanova ◽  
Arash Bohloul ◽  
Xiaoting Guo ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Gadolinium Oxide ◽  
Resonance Imaging ◽  
Magnetic Resonance Imaging Contrast

Controlled Self-Assembling of Gadolinium Nanoparticles as Smart Molecular Magnetic Resonance Imaging Contrast Agents

2011 ◽  
Vol 123 (28) ◽  
pp. 6407-6410 ◽  
Author(s):  
Gaolin Liang ◽  
John Ronald ◽  
Yuanxin Chen ◽  
Deju Ye ◽  
Prachi Pandit ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Resonance Imaging ◽  
Self Assembling ◽  
Magnetic Resonance Imaging Contrast

scholarly journals The Renal Clearable Magnetic Resonance Imaging Contrast Agents: State of the Art and Recent Advances

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 5072
Author(s):  
Xiaodong Li ◽  
Yanhong Sun ◽  
Lina Ma ◽  
Guifeng Liu ◽  
Zhenxin Wang
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Blood Circulation ◽  
Time Window ◽  
Circulation Time ◽  
Great Success ◽  
Resonance Imaging ◽  
Enhanced Sensitivity ◽  
Magnetic Resonance Imaging Contrast

The advancements of magnetic resonance imaging contrast agents (MRCAs) are continuously driven by the critical needs for early detection and diagnosis of diseases, especially for cancer, because MRCAs improve diagnostic accuracy significantly. Although hydrophilic gadolinium (III) (Gd3+) complex-based MRCAs have achieved great success in clinical practice, the Gd3+-complexes have several inherent drawbacks including Gd3+ leakage and short blood circulation time, resulting in the potential long-term toxicity and narrow imaging time window, respectively. Nanotechnology offers the possibility for the development of nontoxic MRCAs with an enhanced sensitivity and advanced functionalities, such as magnetic resonance imaging (MRI)-guided synergistic therapy. Herein, we provide an overview of recent successes in the development of renal clearable MRCAs, especially nanodots (NDs, also known as ultrasmall nanoparticles (NPs)) by unique advantages such as high relaxivity, long blood circulation time, good biosafety, and multiple functionalities. It is hoped that this review can provide relatively comprehensive information on the construction of novel MRCAs with promising clinical translation.

Sign in / Sign up

Export Citation Format

Share Document