scholarly journals Changes in Thermodynamic Interactions at Highly Immiscible Polymer/Polymer Interfaces due to Deuterium Labeling

2006 ◽  
Vol 110 (22) ◽  
pp. 10602-10605 ◽  
Author(s):  
Shane E. Harton ◽  
Frederick A. Stevie ◽  
Zhengmao Zhu ◽  
Harald Ade
Keyword(s):  
Polymer Interfaces ◽  
Deuterium Labeling ◽  
Immiscible Polymer

Ellipsometric studies on immiscible polymer-polymer interfaces

Polymer ◽  
1993 ◽  
Vol 34 (6) ◽  
pp. 1256-1259 ◽  
Author(s):  
Satoshi Yukioka ◽  
Takashi Inoue
Keyword(s):  
Polymer Interfaces ◽  
Immiscible Polymer

scholarly journals Structure and Strength at Immiscible Polymer Interfaces

2013 ◽  
Vol 2 (10) ◽  
pp. 882-886 ◽  
Author(s):  
Ting Ge ◽  
Gary S. Grest ◽  
Mark O. Robbins
Keyword(s):  
Polymer Interfaces ◽  
Immiscible Polymer

Direct Correlation Between Adhesion Promotion and Coupling Reaction at Immiscible Polymer-Polymer Interfaces

2006 ◽  
Vol 82 (9) ◽  
pp. 887-902 ◽  
Author(s):  
Jianbin Zhang ◽  
Phillip J. Cole ◽  
Umang Nagpal ◽  
Christopher W. Macosko ◽  
Timothy P. Lodge
Keyword(s):  
Coupling Reaction ◽  
Polymer Interfaces ◽  
Immiscible Polymer ◽  
Adhesion Promotion

Evidence for Capillary Waves at Immiscible Polymer/Polymer Interfaces

1997 ◽  
Vol 78 (19) ◽  
pp. 3693-3696 ◽  
Author(s):  
M. Sferrazza ◽  
C. Xiao ◽  
R. A. L. Jones ◽  
D. G. Bucknall ◽  
J. Webster ◽  
...  
Keyword(s):  
Capillary Waves ◽  
Polymer Interfaces ◽  
Immiscible Polymer

CHEMISTRY AND MICROSTRUCTURE AT METAL-POLYMER INTERFACES

1988 ◽  
Vol 49 (C5) ◽  
pp. C5-49-C5-59 ◽  
Author(s):  
P. S. HO ◽  
R. HAIGHT ◽  
R. C. WHITE ◽  
B. D. SILVERMAN
Keyword(s):  
Polymer Interfaces ◽  
Metal Polymer

scholarly journals Esterifications with 2-(Trimethylsilyl)ethyl 2,2,2-Trichloroacetimidate

Organics ◽  
2021 ◽  
Vol 2 (1) ◽  
pp. 17-25
Author(s):  
Wenhong Lin ◽  
Shea T. Meyer ◽  
Shawn Dormann ◽  
John D. Chisholm
Keyword(s):  
Carboxylic Acid ◽  
High Yield ◽  
Deuterium Labeling ◽  
Ester Formation ◽  
Acid Substrate

2-(Trimethylsilyl)ethyl 2,2,2-trichloroacetimidate is readily synthesized from 2-trimethylsilylethanol in high yield. This imidate is an effective reagent for the formation of 2-trimethylsilylethyl esters without the need for an exogenous promoter or catalyst, as the carboxylic acid substrate is acidic enough to promote ester formation without an additive. A deuterium labeling study indicated that a β-silyl carbocation intermediate is involved in the transformation.

scholarly journals FSMP-06. IN VIVO MONITORING OF LDHA EXPRESSION IN GLIOBLASTOMA USING QUANTITATIVE EXCHANGED-LABEL TURNOVER 1H MRS TECHNIQUE

2020 ◽  
Vol 3 (Supplement_1) ◽  
pp. i17-i17
Author(s):  
Puneet Bagga ◽  
Laurie Rich ◽  
Mohammad Haris ◽  
Neil Wilson ◽  
Mitch Schnall ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Lactate Production ◽  
Deuterium Labeling ◽  
1H Mrs ◽  
In Vivo Monitoring ◽  
Lactate Turnover ◽  
Crucial Information ◽  
Specialized Hardware

Abstract Most cancers, including glioblastomas (GBMs), rely extensively on glycolysis to support growth, proliferation, and survival. A hallmark of this elevated glycolysis is overexpression of Lactate dehydrogenase-A (LDHA) protein leading to increased uptake of glucose and overproduction of lactate. Various clinical trials using LDHA as a target for diagnosis and treatment have yielded encouraging results. However, in vivo monitoring of LDHA expression has been challenging due to either requirement of administration of radioactive substrates or specialized hardware. In this presentation, we will demonstrate a new method-quantitative exchanged-label turnover MRS (QELT, or simply qMRS)-that increases the sensitivity of magnetic resonance-based metabolic mapping without the requirement for specialized hardware. qMRS relies on the administration of deuterated (2H-labeled) substrates to track the production of downstream metabolites. Since 2H is invisible on 1H MRS, replacement of 1H with 2H due to metabolic turnover leads to an overall reduction in 1H MRS signal for the corresponding metabolites. We applied our qMRS technique to monitor the rate of lactate production in a preclinical GBM model. Infusion of [6,6’-2H2]glucose led to downstream deuterium labeling of lactate, thereby resulting in a reduction in the 1.33 ppm lactate-CH3 peak on 1H MRS over time. The subtraction of post-administration 1H MR spectra from the pre-infusion spectra aided in the determination of the kinetics of the lactate turnover. We believe that the detection and quantification of lactate production kinetics may provide crucial information regarding tumor LDHA expression non-invasively in GBMs without requiring biopsies. Hence, qMRS is expected to open up new opportunities to probe LDHA expression differences in a variety of gliomas, including GBMs and astrocytomas. This method takes advantage of the universal availability and ease of implementation of 1H MRS on all clinical and preclinical magnetic resonance scanners.

Sign in / Sign up

Export Citation Format

Share Document