scholarly journals Simulated Reversible Aggregation Processes for Different Interparticle Potentials:  The Cluster Aging Phenomenon

2003 ◽  
Vol 107 (50) ◽  
pp. 14145-14145 ◽  
Author(s):  
G. Odriozola ◽  
A. Schmitt ◽  
J. Callejas-Fernández ◽  
R. Martínez-García ◽  
R. Hidalgo-Álvarez
Keyword(s):  
Reversible Aggregation ◽  
Aggregation Processes ◽  
Interparticle Potentials ◽  
Aging Phenomenon

scholarly journals Simulated Reversible Aggregation Processes for Different Interparticle Potentials: The Cluster Aging Phenomenon

2003 ◽  
Vol 107 (10) ◽  
pp. 2180-2188 ◽  
Author(s):  
G. Odriozola ◽  
A. Schmitt ◽  
J. Callejas-Fernández ◽  
R. Martínez-García ◽  
R. Leone ◽  
...  
Keyword(s):  
Reversible Aggregation ◽  
Aggregation Processes ◽  
Interparticle Potentials ◽  
Aging Phenomenon

SCALING LAWS OF REVERSIBLE AGGREGATION IN COMPACT CLUSTER SYSTEMS

2000 ◽  
Vol 14 (09) ◽  
pp. 983-991
Author(s):  
GUOCE ZHUANG ◽  
JIAFU WANG ◽  
WEI WANG
Keyword(s):  
Scaling Laws ◽  
Mean Field ◽  
Cluster Systems ◽  
Scaling Properties ◽  
Cluster Aggregation ◽  
Reversible Aggregation ◽  
A Value ◽  
Aggregation Processes ◽  
The Mean ◽  
Compact Cluster

The reversible cluster–cluster aggregation processes in compact cluster systems are studied via a scaling argument and Monte Carlo simulations. To describe the detail effects of fragmentations from tree-like fractal to compact clusters a relative breakup probability [Formula: see text] with an exponent β is introduced. The mean-field rate equation and numerical simulation results indicate that the critical exponent y, which is defined as <s (k, ∞)> ~ k-y, has a value of (α + ξ - β + 2)-1. It is shown that the scaling properties of the cluster size distributions are determined by the selections of the exponents α, β and ξ.

Constant bond breakup probability model for reversible aggregation processes

2002 ◽  
Vol 65 (3) ◽  
Author(s):  
G. Odriozola ◽  
A. Schmitt ◽  
A. Moncho-Jordá ◽  
J. Callejas-Fernández ◽  
R. Martínez-García ◽  
...  
Keyword(s):  
Probability Model ◽  
Reversible Aggregation ◽  
Aggregation Processes

Erratum: Constant bond breakup probability model for reversible aggregation processes [Phys. Rev. E65, 031405 (2002)]

2003 ◽  
Vol 68 (6) ◽  
Author(s):  
G. Odriozola ◽  
A. Schmitt ◽  
A. Moncho-Jordá ◽  
J. Callejas-Fernández ◽  
R. Martínez-García ◽  
...  
Keyword(s):  
Probability Model ◽  
Reversible Aggregation ◽  
Aggregation Processes

Reversible aggregation processes with time-dependent rate kernels

2004 ◽  
Vol 331 (5) ◽  
pp. 281-287 ◽  
Author(s):  
Jianhong Ke ◽  
Xiao-Ou Cai ◽  
Zhenquan Lin
Keyword(s):  
Time Dependent ◽  
Dependent Rate ◽  
Reversible Aggregation ◽  
Aggregation Processes

Aggregation of Cat Platelets in Vitro

1970 ◽  
Vol 23 (03) ◽  
pp. 601-620 ◽  
Author(s):  
Th. B Tschopp
Keyword(s):  
Adenosine Monophosphate ◽  
Blood Collection ◽  
Base Line ◽  
Reversible Aggregation ◽  
Low Concentrations ◽  
Irreversible Aggregation ◽  
High Concentrations ◽  
Two Phases ◽  
Improved Technique

SummaryAggregation of cat platelets in the citrated plasma is examined by means of Born’s absorptiometer. A marked tendency of the platelets of this species to spontaneous aggregation necessitated first of all the development of an improved technique of blood collection.A hypothesis according to which 5-HT is released from the platelets, explains the absence of oscillations on the base line of the absorptiometer, the absence of platelet swelling, when ADP is added, and the effect of stirring on the aggregation curves in cat PRP. The average volume of cat platelets amounts to 10.46 μ3 when directly fixed in the blood, when fixed from PRP to 12.17 μ3, when fixed from stirred PRP to 13.51 μ3.In low concentrations (0.3-2 μM) ADP produce reversible aggregation; in narrowly restricted, individually dissimilar mean concentrations irreversible aggregation in two phases and in high concentrations, irreversible aggregation in one phase. Like ADP serotonin produces 2 phase irreversible aggregation in concentrations of 3-10 μM, but unlike ADP, the aggregation velocity decreases again with high 5-HT concentrations (>100 μM). Adrenaline does not produce aggregation and it is likely that adenosine and adenosine monophosphate inhibit the aggregation by serotonin but not by ADP. Species differences in the aggregation of human, rabbit and cat platelets are discussed.

Functional Fractionation of Platelets: Aggregation Kinetics and Glycoprotein Labeling of Differing Platelet Populations

1982 ◽  
Vol 48 (02) ◽  
pp. 211-216 ◽  
Author(s):  
V M Haver ◽  
A R L Gear
Keyword(s):  
Galactose Oxidase ◽  
Aggregation Kinetics ◽  
Maximal Rate ◽  
Membrane Glycoproteins ◽  
Whole Cells ◽  
Reversible Aggregation ◽  
Significant Difference ◽  
Small Doses ◽  
Major Loss ◽  
Kinetics Of

SummaryPlatelet heterogeneity has been studied with a technique called functional fractionation which employs gentle centrifugation to yield subpopulations (“reactive” and “less-reactive” platelets) after exposure to small doses of aggregating agent. Aggregation kinetics of the different platelet populations were investigated by quenched-flow aggregometry. The large, “reactive” platelets were more sensitive to ADP (Ka = 1.74 μM) than the smaller “less-reactive” platelets (Ka = 4.08 μM). However, their maximal rate of aggregation (Vmax, % of platelets aggregating per sec) of 23.3 was significantly lower than the “less-reactive” platelets (Vmax = 34.7). The “reactive” platelets had a 2.2 fold higher level of cyclic AMP.Platelet glycoproteins were labeled using the neuraminidase-galactose oxidase – [H3]-NaBH4 technique. When platelets were labeled after reversible aggregation, the “reactive” platelets showed a two-fold decrease in labeling efficiency (versus control platelets). However, examination of whole cells or membrane preparations from reversibly aggregated platelets revealed no significant difference in Coomassie or PAS (Schiff) staining.These results suggest that the large, “reactive” platelets are more sensitive to ADP but are not hyperaggregable in a kinetic sense. Reversible aggregation may cause a re-orientation of membrane glycoproteins that is apparently not characterized by a major loss of glycoprotein material.

Early Platelet-Collagen Interactions in Whole Blood and Their Modifications by Aspirin and Dipyridamole Evaluated by a New Method (Basic Wave)

1985 ◽  
Vol 54 (04) ◽  
pp. 799-803 ◽  
Author(s):  
José Luís Pérez-Requejo ◽  
Justo Aznar ◽  
M Teresa Santos ◽  
Juana Vallés
Keyword(s):  
Whole Blood ◽  
Ex Vivo ◽  
Platelet Rich Plasma ◽  
White Blood Cells ◽  
Reversible Aggregation ◽  
Inhibitory Compounds ◽  
Rapid Generation ◽  
Stimulation Of ◽  
Collagen Stimulation

SummaryIt is shown that the supernatant of unstirred whole blood at 37° C, stimulated by 1 μg/ml of collagen for 10 sec, produces a rapid generation of pro and antiaggregatory compounds with a final proaggregatory activity which can be detected for more than 60 min on a platelet rich plasma (PRP) by turbidometric aggregometry. A reversible aggregation wave that we have called BASIC wave (for Blood Aggregation Stimulatory and Inhibitory Compounds) is recorded. The collagen stimulation of unstirred PRP produces a similar but smaller BASIC wave. BASIC’s intensity increases if erythrocytes are added to PRP but decreases if white blood cells are added instead. Aspirin abolishes “ex vivo” the ability of whole blood and PRP to generate BASIC waves and dipyridamole “in vitro” significantly reduces BASIC’s intensity in whole blood in every tested sample, but shows little effect in PRP.

Role of the Structural Characteristics of Dendrimers in the Manifestation of the Antiamyloid Properties

INEOS OPEN ◽  
2020 ◽  
Vol 3 ◽  
Author(s):  
S. A. Sorokina ◽  
◽  
Yu. Yu. Stroilova ◽  
V. I. Muronets ◽  
Z. B. Shifrina ◽  
...  
Keyword(s):  
Neurodegenerative Diseases ◽  
Structural Characteristics ◽  
Short Review ◽  
External Factors ◽  
Amyloid Aggregation ◽  
Amyloid Proteins ◽  
Molecular Parameters ◽  
Amyloid Aggregates ◽  
Aggregation Processes

Among the compounds able to efficiently inhibit the amyloid aggregation of proteins and decompose the amyloid aggregates that cause neurodegenerative diseases, of particular interest are dendrimers, which represent individual macromolecules with the hypercrosslinked architectures and given molecular parameters. This short review outlines the peculiarities of the antiamyloid activity of dendrimers and discusses the effect of dendrimer structures and external factors on their antiamyloid properties. The potential of application of dendrimers in further investigations on the aggregation processes of amyloid proteins as the compounds that exhibit the remarkable antiamyloid activity is evaluated.

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