Microscopic Protonation Equilibria of Oxidized Glutathione

2003 ◽  
Vol 107 (21) ◽  
pp. 5074-5080 ◽  
Author(s):  
Béla Noszál ◽  
Zoltán Szakács
Keyword(s):  
Oxidized Glutathione ◽  
Protonation Equilibria

Leucocyte-depleted cardioplegia does not reduce reperfusion injury in hypothermic coronary artery bypass surgery

Perfusion ◽  
1999 ◽  
Vol 14 (5) ◽  
pp. 371-377 ◽  
Author(s):  
P G Browning ◽  
M Pullan ◽  
M Jackson ◽  
A Rashid
Keyword(s):  
Oxidative Stress ◽  
Coronary Artery ◽  
Coronary Artery Bypass ◽  
Coronary Artery Bypass Surgery ◽  
Myocardial Injury ◽  
Bypass Surgery ◽  
Troponin T ◽  
Artery Bypass ◽  
Oxidized Glutathione ◽  
Patient Groups

This study investigated the effects of leucocyte-depleted cardioplegia on postreperfusion oxidative stress and myocardial injury in elective hypothermic coronary artery bypass surgery. Forty patients were randomized to receive either cardioplegia with leucocytes depleted by an in-line Pall BC1B filter, or blood cardioplegia without leucocyte depletion. Transmyocardial oxidative stress was assessed by oxidized glutathione measurements in samples taken simultaneously from the coronary sinus and aortic root, and myocardial injury by postoperative CKMB and troponin-T measurements. The BC1B filters reduced numbers of cardioplegia leucocytes by a mean of 90.7%. Both patient groups demonstrated significant increases ( p < 0.001) in transcardiac oxidized glutathione gradients after crossclamp release. No significant differences were found between the groups for postreperfusion oxidized glutathione gradients, postoperative levels of CKMB or troponin-T, or in the frequency of perioperative and postoperative complications. These results suggest that leucocyte-depleted cardioplegia does not significantly improve myocardial protection in patients undergoing elective coronary artery bypass surgery.

The interaction of the VO2+ cation with oxidized glutathione

1993 ◽  
Vol 50 (4) ◽  
pp. 253-262 ◽  
Author(s):  
Evelina G. Ferrer ◽  
Patricia A.M. Williams ◽  
Enrique J. Baran
Keyword(s):  
Oxidized Glutathione

p-Aminobenzoic Acid Protonation Dynamics in an Evaporating Droplet by Ab Initio Molecular Dynamics

2021 ◽  
Author(s):  
Patrick Rodrigues Batista ◽  
Tatiana Casselli Penna ◽  
Lucas C Ducati ◽  
Thiago Carita Correra
Keyword(s):  
Molecular Dynamics ◽  
Ab Initio ◽  
Ab Initio Molecular Dynamics ◽  
Aminobenzoic Acid ◽  
Protonation Equilibria ◽  
Physical Phenomena

Protonation equilibria are known to vary from the bulk to microdroplet conditions, which could induce many chemical and physical phenomena. Protonated p-aminobenzoic acid (PABA+H+) can be considered a model for...

scholarly journals Fluorescent benzimidazo[1,2-a]quinolines: synthesis, spectroscopic and computational studies of protonation equilibria and metal ion sensitivity

2017 ◽  
Vol 41 (1) ◽  
pp. 358-371 ◽  
Author(s):  
Marijana Hranjec ◽  
Ema Horak ◽  
Darko Babić ◽  
Sanela Plavljanin ◽  
Zrinka Srdović ◽  
...  
Keyword(s):  
Metal Ion ◽  
Computational Studies ◽  
Protonation Equilibria

Novel benzimidazo[1,2-a]quinolines with promising pH and chemosensing properties are experimentally and computationally characterized.

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