An Efficient, Stereospecific Synthesis of the Dimer-Selective Retinoid X Receptor Modulator (2E,4E,6Z)-7-[5,6,7,8- Tetrahydro-5,5,8,8-tetramethyl-2- (n-propyloxy)naphthalen-3-yl]-3- methylocta-2,4,6-trienoic Acid

Lawrence G. Hamann

doi:10.1021/jo991936x

An Efficient, Stereospecific Synthesis of the Dimer-Selective Retinoid X Receptor Modulator (2E,4E,6Z)-7-[5,6,7,8- Tetrahydro-5,5,8,8-tetramethyl-2- (n-propyloxy)naphthalen-3-yl]-3- methylocta-2,4,6-trienoic Acid

The Journal of Organic Chemistry ◽

10.1021/jo991936x ◽

2000 ◽

Vol 65 (10) ◽

pp. 3233-3235 ◽

Cited By ~ 12

Author(s):

Lawrence G. Hamann

Keyword(s):

Retinoid X Receptor ◽

Trienoic Acid ◽

Stereospecific Synthesis ◽

Receptor Modulator

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ChemInform Abstract: An Efficient, Stereospecific Synthesis of the Dimer-Selective Retinoid X Receptor Modulator (2E,4E,6Z)-7- [5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-(n-propyloxy)naphthalen-3-yl] -3-methylocta-2,4,6-trienoic Acid.

ChemInform ◽

10.1002/chin.200036098 ◽

2010 ◽

Vol 31 (36) ◽

pp. no-no

Author(s):

Lawrence G. Hamann

Keyword(s):

Retinoid X Receptor ◽

Trienoic Acid ◽

Stereospecific Synthesis ◽

Receptor Modulator

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Biological Characterization of a Heterodimer-Selective Retinoid X Receptor Modulator: Potential Benefits for the Treatment of Type 2 Diabetes

Endocrinology ◽

10.1210/en.2005-0690 ◽

2006 ◽

Vol 147 (2) ◽

pp. 1044-1053 ◽

Cited By ~ 49

Author(s):

Mark D. Leibowitz ◽

Robert J. Ardecky ◽

Marcus F. Boehm ◽

Carol L. Broderick ◽

Mark A. Carfagna ◽

...

Keyword(s):

Type 2 Diabetes ◽

Retinoid X Receptor ◽

Biological Characterization ◽

Receptor Modulator ◽

Potential Benefits

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Novel (2E,4E,6Z)-7-(2-Alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic Acid Retinoid X Receptor Modulators Are Active in Models of Type 2 Diabetes

Journal of Medicinal Chemistry ◽

10.1021/jm020340q ◽

2003 ◽

Vol 46 (13) ◽

pp. 2683-2696 ◽

Cited By ~ 42

Author(s):

P. Y. Michellys ◽

R. J. Ardecky ◽

J. H. Chen ◽

D. L. Crombie ◽

G. J. Etgen ◽

...

Keyword(s):

Type 2 Diabetes ◽

Retinoid X Receptor ◽

Trienoic Acid ◽

Receptor Modulators

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368: The Analysis of Vitamin D Receptor and Retinoid X Receptor in Renal Cell Carcinoma

The Journal of Urology ◽

10.1016/s0022-5347(18)34621-4 ◽

2005 ◽

Vol 173 (4S) ◽

pp. 101-101

Author(s):

Wataru Obara ◽

Ryuichiro Konda ◽

Tomoaki Fujioka

Keyword(s):

Renal Cell Carcinoma ◽

Vitamin D ◽

Cell Carcinoma ◽

Vitamin D Receptor ◽

Renal Cell ◽

Retinoid X Receptor

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721: Raloxifene, a Selective Estrogen Receptor Modulator, Induces Apoptosis in Bladder Cancer Cell Lines

The Journal of Urology ◽

10.1016/s0022-5347(18)37970-9 ◽

2004 ◽

Vol 171 (4S) ◽

pp. 191-192 ◽

Cited By ~ 1

Author(s):

Isaac Y. Kim ◽

Jian Yu ◽

Moses M. Kim ◽

Seth P. Lerner

Keyword(s):

Bladder Cancer ◽

Estrogen Receptor ◽

Cell Lines ◽

Cancer Cell ◽

Cancer Cell Lines ◽

Selective Estrogen Receptor Modulator ◽

Bladder Cancer Cell ◽

Receptor Modulator

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A double-blind, randomized, placebo-controlled phase 3 study to assess the efficacy and safety of relacorilant, a selective glucocorticoid receptor modulator, in patients with hypercortisolism due to cortisol-secreting adrenal adenoma(s)/hyperplasia

Endocrine Abstracts ◽

10.1530/endoabs.70.aep17 ◽

2020 ◽

Author(s):

Iacopo Chiodini ◽

Andreas Grauer ◽

Andreas Moraitis ◽

Massimo Terzolo

Keyword(s):

Glucocorticoid Receptor ◽

Adrenal Adenoma ◽

Efficacy And Safety ◽

Phase 3 ◽

Double Blind ◽

Receptor Modulator

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The impact of the selective progesterone receptor modulator (SPRM), ulipristal acetate (UPA) administration upon cell proliferation markers within the human endometrium

Reproduction Abstracts ◽

10.1530/repabs.3.p038 ◽

2016 ◽

Author(s):

Rebecca Matthews ◽

Alison Murray ◽

Lucy Whitaker ◽

Michael Millar ◽

Moira Nicol ◽

...

Keyword(s):

Cell Proliferation ◽

Progesterone Receptor ◽

Human Endometrium ◽

Proliferation Markers ◽

Ulipristal Acetate ◽

Receptor Modulator ◽

The Impact

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Stereospecific synthesis of 11Z-hexadedenal – the main component of the sex pheromone of Helicoverpa armigera Hbn. from the cyclodimer of butadiene and isoprene

PROCEEDINGS OF IV INTERNATIONAL SCIENTIFIC CONFERENCE “CURRENT STATE, PROBLEMS AND PROSPECTS OF THE DEVELOPMENT OF AGRARIAN SCIENCE” ◽

10.33952/09.09.2019.174 ◽

2019 ◽

Author(s):

G.Yu. Ishmuratov ◽

◽

Yu.V. Myasoedova ◽

L.R. Garifullina ◽

E.R. Nurieva ◽

...

Keyword(s):

Sex Pheromone ◽

Helicoverpa Armigera ◽

Stereospecific Synthesis ◽

Helicoverpa Armígera ◽

Main Component

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Faculty Opinions recommendation of Imaging of selective nuclear receptor modulator-induced conformational changes in the nuclear receptor to allow interaction with coactivator and corepressor proteins in living cells.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1087512.540565 ◽

2007 ◽

Author(s):

John Proudfoot

Keyword(s):

Nuclear Receptor ◽

Conformational Changes ◽

Living Cells ◽

Receptor Modulator

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Faculty Opinions recommendation of A dissociated glucocorticoid receptor modulator reduces airway hyperresponsiveness and inflammation in a mouse model of asthma.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.716398061.791803121 ◽

2012 ◽

Author(s):

Yassine Amrani

Keyword(s):

Mouse Model ◽

Glucocorticoid Receptor ◽

Airway Hyperresponsiveness ◽

Receptor Modulator

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