Stereoselective Synthesis of Trifluoromethylated Compounds:  Nucleophilic Addition of FormaldehydeN,N-Dialkylhydrazones to Trifluoromethyl Ketones

1999 ◽  
Vol 64 (24) ◽  
pp. 8846-8854 ◽  
Author(s):  
Carmen Pareja ◽  
Eloísa Martín-Zamora ◽  
Rosario Fernández ◽  
José M. Lassaletta
Keyword(s):  
Nucleophilic Addition ◽  
Stereoselective Synthesis ◽  
Trifluoromethyl Ketones

ChemInform Abstract: Silver Salts and DBU Cooperatively Catalyzed Nucleophilic Addition/Cyclization of Propargylic Alcohols with Trifluoromethyl Ketones.

ChemInform ◽  
2015 ◽  
Vol 46 (36) ◽  
pp. no-no
Author(s):  
Jingjing Wang ◽  
Wei-Guang Kong ◽  
Feng Li ◽  
Jie Liu ◽  
Qin Shen ◽  
...  
Keyword(s):  
Nucleophilic Addition ◽  
Propargylic Alcohols ◽  
Trifluoromethyl Ketones ◽  
Silver Salts

Silver salts and DBU cooperatively catalyzed nucleophilic addition/cyclization of propargylic alcohols with trifluoromethyl ketones

2015 ◽  
Vol 13 (19) ◽  
pp. 5399-5406 ◽  
Author(s):  
Jingjing Wang ◽  
Wei-Guang Kong ◽  
Feng Li ◽  
Jie Liu ◽  
Qin Shen ◽  
...  
Keyword(s):  
Nucleophilic Addition ◽  
Silver Salt ◽  
Efficient Synthesis ◽  
Propargylic Alcohols ◽  
Trifluoromethyl Ketones ◽  
Silver Salts

A general and efficient synthesis of trifluoromethyl substituted 5-alkylidene-1,3-dioxolane using a silver salt and DBU cooperatively catalyzed nucleophilic addition/cyclization of propargylic alcohols and trifluoromethyl ketones is described.

Stereoselective Synthesis of 3-Substituted and 3,4-Disubstituted Piperidine und Piperidin-2-one Derivatives

2012 ◽  
Vol 67 (4) ◽  
pp. 389-405 ◽  
Author(s):  
Ellen Klegraf ◽  
Horst Kunz
Keyword(s):  
Nucleophilic Addition ◽  
Stereoselective Synthesis ◽  
Organometallic Reagents

The stereoselective synthesis of 3-substituted and 3,4-disubstituted piperidine and piperidin-2-one derivatives was achieved starting from 2-pyridone. After N-galactosylation and subsequent O-silylation, nucleophilic addition of organometallic reagents proceeded with high regio- and stereoselectivity at 4-position. Substituents at position 3 were stereoselectively introduced by reaction of electrophiles with amide enolates of the N-galactosyl-2-piperidones.

Stereoselective synthesis of fully substituted ethylenes via an Ag-catalyzed 1,6-nucleophilic addition/annulation cascade

2020 ◽  
Vol 56 (56) ◽  
pp. 7749-7752
Author(s):  
Bu-Zheng Tang ◽  
Wen-Juan Hao ◽  
Jia-Zhuo Li ◽  
Shan-Shan Zhu ◽  
Shu-Jiang Tu ◽  
...  
Keyword(s):  
Nucleophilic Addition ◽  
Stereoselective Synthesis ◽  
First Time

A catalytic 1,6-nucleophilic addition/annulation cascade was developed for the first time, and used to produce 27 hitherto unreported ethylene-linked 1-naphthol-imidazole pairs with generally good yields and complete stereoselectivity.

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