The First Application of a Planar-Chiral Phosphorus Heterocycle in Asymmetric Catalysis:  Enantioselective Hydrogenation of Dehydroamino Acids

1998 ◽  
Vol 63 (13) ◽  
pp. 4168-4169 ◽  
Author(s):  
Shuang Qiao ◽  
Gregory C. Fu
Keyword(s):  
Asymmetric Catalysis ◽  
Enantioselective Hydrogenation ◽  
Dehydroamino Acids

H8-MonoPhos and its application in catalytic enantioselective hydrogenation of α-dehydroamino acids

Tetrahedron ◽  
2002 ◽  
Vol 58 (43) ◽  
pp. 8799-8803 ◽  
Author(s):  
Qingle Zeng ◽  
Hui Liu ◽  
Aiqiao Mi ◽  
Yaozhong Jiang ◽  
Xingshu Li ◽  
...  
Keyword(s):  
Enantioselective Hydrogenation ◽  
Dehydroamino Acids

Metal–ligand bifunctional catalysis for asymmetric hydrogenation

2005 ◽  
Vol 363 (1829) ◽  
pp. 901-912 ◽  
Author(s):  
Ryoji Noyori ◽  
Christian A Sandoval ◽  
Kilian Muñiz ◽  
Takeshi Ohkuma
Keyword(s):  
Asymmetric Catalysis ◽  
Asymmetric Hydrogenation ◽  
Enantioselective Hydrogenation ◽  
Molecular Surface ◽  
Metal Alkoxide ◽  
Bifunctional Catalysis ◽  
Bifunctional Mechanism ◽  
Prochiral Ketones ◽  
Membered Transition State ◽  
Metal Ligand

Chiral diphosphine/1,2-diamine–Ru(II) complexes catalyse the rapid, productive and enantioselective hydrogenation of simple ketones. The carbonyl-selective hydrogenation takes place via a non-classical metal–ligand bifunctional mechanism. The reduction of the C=O function occurs in the outer coordination sphere of an 18e trans -RuH 2 (diphosphine)(diamine) complex without interaction between the unsaturated moiety and the metallic centre. The Ru atom donates a hydride and the NH 2 ligand delivers a proton through a pericyclic six-membered transition state, directly giving an alcoholic product without metal alkoxide formation. The enantiofaces of prochiral ketones are differentiated on the chiral molecular surface of the saturated RuH 2 species. This asymmetric catalysis manifests the significance of ‘kinetic’ supramolecular chemistry.

Rhodium-hydroxyl bisphospholane catalyzed highly enantioselective hydrogenation of dehydroamino acids and esters

1999 ◽  
Vol 40 (37) ◽  
pp. 6701-6704 ◽  
Author(s):  
Wenge Li ◽  
Zhaoguo Zhang ◽  
Dengming Xiao ◽  
Xumu Zhang
Keyword(s):  
Enantioselective Hydrogenation ◽  
Dehydroamino Acids

ChemInform Abstract: Highly Enantioselective Hydrogenation of α-Dehydroamino Acids by Rhodium Complex with H8-MonoPhos.

ChemInform ◽  
2010 ◽  
Vol 33 (32) ◽  
pp. no-no
Author(s):  
Qingle Zeng ◽  
Hui Liu ◽  
Xin Cui ◽  
Aiqiao Mi ◽  
Yaozhong Jiang ◽  
...  
Keyword(s):  
Enantioselective Hydrogenation ◽  
Rhodium Complex ◽  
Dehydroamino Acids

H8-MonoPhos and Its Application in Catalytic Enantioselective Hydrogenation of α-Dehydroamino Acids.

ChemInform ◽  
2003 ◽  
Vol 34 (7) ◽  
Author(s):  
Qingle Zeng ◽  
Hui Liu ◽  
Aiqiao Mi ◽  
Yaozhong Jiang ◽  
Xingshu Li ◽  
...  
Keyword(s):  
Enantioselective Hydrogenation ◽  
Dehydroamino Acids
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