Direct Synthesis of Terminal AlkynesviaPd-Catalyzed Cross Coupling of Aryl and Alkenyl Halides with Ethynylmetals Containing Zn, Mg, and Sn. Critical Comparison of Countercations

1997 ◽  
Vol 62 (25) ◽  
pp. 8957-8960 ◽  
Author(s):  
Ei-ichi Negishi ◽  
Martin Kotora ◽  
Caiding Xu
Keyword(s):  
Direct Synthesis ◽  
Cross Coupling ◽  
Critical Comparison

Direct Synthesis of Palladium Catalyst on Supporting WS2Nanotubes and its Reactivity in Cross-Coupling Reactions

2015 ◽  
Vol 10 (10) ◽  
pp. 2234-2239 ◽  
Author(s):  
Bojana Višić ◽  
Hagai Cohen ◽  
Ronit Popovitz-Biro ◽  
Reshef Tenne ◽  
Viacheslav I. Sokolov ◽  
...  
Keyword(s):  
Palladium Catalyst ◽  
Direct Synthesis ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
Cross Coupling Reactions

Direct Synthesis of Tri/Difluoromethyl Ketones from Carboxylic Acids via Cross‐Coupling with Acyloxyphosphonium Ions

2021 ◽  
Author(s):  
Surya G. Prakash ◽  
Xanath Ispizua-Rodriguez ◽  
Socrates Munoz ◽  
Vinayak Krishnamurti ◽  
Thomas Mathew
Keyword(s):  
Carboxylic Acids ◽  
Direct Synthesis ◽  
Cross Coupling

Cobalt(III)‐Catalyzed and Dimethyl Sulfoxide‐Involved Cross‐Coupling of Ketones and Amides for Direct Synthesis of β ‐Amino Ketones

2019 ◽  
Vol 361 (18) ◽  
pp. 4278-4285 ◽  
Author(s):  
Xuefeng Xu ◽  
Zhi Zhou ◽  
Zhipin Wang ◽  
Xinna Ma ◽  
Xin Chen ◽  
...  
Keyword(s):  
Dimethyl Sulfoxide ◽  
Direct Synthesis ◽  
Cross Coupling

ChemInform Abstract: The Direct Synthesis of Novel Enantiomerically Pure α-Amino Acids in Protected Form via Suzuki Cross-Coupling.

ChemInform ◽  
2000 ◽  
Vol 31 (48) ◽  
pp. no-no
Author(s):  
Philip N. Collier ◽  
Andrew D. Campbell ◽  
Ian Patel ◽  
Richard J. K. Taylor
Keyword(s):  
Amino Acids ◽  
Direct Synthesis ◽  
Cross Coupling ◽  
Enantiomerically Pure

scholarly journals Direct Synthesis and Applications of Solid Silylzinc Reagents

2021 ◽  
Author(s):  
Ramesh Rasappan ◽  
Revathi Chandrasekaran ◽  
Feba Thomas Pulikkottil ◽  
Krishna Suresh
Keyword(s):  
Detrimental Effect ◽  
Functional Group ◽  
Direct Synthesis ◽  
Cross Coupling ◽  
Synthetic Methods ◽  
Synthetic Method ◽  
General Applicability ◽  
Alkyl Aryl ◽  
Synthetic Utility ◽  
First Time

The increased synthetic utility of organosilanes motivates researchers to develop a milder and more practical synthetic methods. Silylzinc reagents, which are typically the most functional group tolerant, are notoriously difficult to synthesize because they are obtained by a pyrophoric reaction of silyllithium, particularly Me3 SiLi itself prepared by the reaction of MeLi and disilane. Furthermore, the dissolved LiCl in silylzinc may have a detrimental effect. A synthetic method that can avoid silyllithium and involves a direct synthesis of silylzinc reagents from silyl halides is arguably the simplest and economical strategy. We describe for the first time, the direct synthesis of PhMe2 SiZnI and Me3 SiZnI reagents by employing a coordinating TMEDA ligand, as well as single crystal XRD structures. Importantly, they can be obtained as solid and stored for longer periods of time. We demonstrate their significance in cross-coupling of various free alkyl/aryl/alkenyl carboxylic acids with broader functional group tolerance and API derivatives. The general applicability and efficiency of solid Me3 SiZnI are shown in a wide variety of reactions including alkylation, arylation, allylation, 1,4-addition, acylation and more.

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