One-Pot Chemoenzymatic Synthesis of 3‘-Functionalized Cephalosporines (Cefazolin) by Three Consecutive Biotransformations in Fully Aqueous Medium

1997 ◽  
Vol 62 (26) ◽  
pp. 9099-9106 ◽  
Author(s):  
O. H. Jústiz ◽  
R. Fernández-Lafuente ◽  
J. M. Guisán ◽  
P. Negri ◽  
G. Pagani ◽  
...  
Keyword(s):  
Aqueous Medium ◽  
Chemoenzymatic Synthesis ◽  
One Pot

A One-Pot Chemoenzymatic Synthesis of (2S,4R)-4-Methylproline Enables the First Total Synthesis of Antiviral Lipopeptide Cavinafungin B

2018 ◽  
Author(s):  
Christian R. Zwick ◽  
Hans Renata
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Complex Molecule ◽  
Molecular Target ◽  
Chemoenzymatic Synthesis ◽  
General Strategy ◽  
One Pot

We report an efficient ten-step synthesis of antiviral natural product cavinafungin B in 37% overall yield. By leveraging a one-pot chemoenzymatic synthesis of (2S,4R)-4-methylproline and oxazolidine-tethered (Rink-Boc-ATG-resin) SPPS methodology, the assembly of our molecular target could be conducted in an efficient manner.This general strategy could prove amenable to the construction of other natural and unnatural linear lipopeptides. The value of incorporating biocatalytic steps in complex molecule synthesis is highlighted by this work.

A Facile One-Pot and Green Multi-Component Synthesis of 2-Amino-4Hpyrans Promoted by Pyridinium p-Toluenesulfonate in Aqueous Medium

2016 ◽  
Vol 13 (7) ◽  
pp. 482-490 ◽  
Author(s):  
Chaima Boureghda ◽  
Imène Amine Khodja ◽  
Bertrand Carboni ◽  
Raouf Boulcina ◽  
Oumeima Kermiche ◽  
...  
Keyword(s):  
Aqueous Medium ◽  
One Pot

Iodine Catalyzed Highly Efficient One Pot Three Component Synthesis of 4-arylidene-3-methylisoxazol-5 (4H) -one in Aqueous Medium

2018 ◽  
Vol 5 (2) ◽  
pp. 122-128 ◽  
Author(s):  
Srinivas L. Nakkalwar ◽  
Shivaji B. Patwari ◽  
Mohasim M. Patel ◽  
Vivekanand B. Jadhav
Keyword(s):  
Aqueous Medium ◽  
One Pot ◽  
Highly Efficient

ChemInform Abstract: Nanodomain Cubic Cuprous Oxide as Reusable Catalyst in One-Pot Synthesis of 3-Alkyl/Aryl-3- (pyrrole-2-yl/indole-3-yl)-2-phenyl-2,3-dihydro-isoindolinones in Aqueous Medium.

ChemInform ◽  
2014 ◽  
Vol 45 (41) ◽  
pp. no-no
Author(s):  
Swarbhanu Sarkar ◽  
Nivedita Chatterjee ◽  
Manas Roy ◽  
Rammyani Pal ◽  
Sabyasachi Sarkar ◽  
...  
Keyword(s):  
Aqueous Medium ◽  
Cuprous Oxide ◽  
Reusable Catalyst ◽  
One Pot ◽  
Alkyl Aryl ◽  
One Pot Synthesis

A One-Pot, Green Synthesis of Betti Base Containing Adenine Derivatives in Aqueous Medium

Heterocycles ◽  
2017 ◽  
Vol 94 (2) ◽  
pp. 297
Author(s):  
Qiang Lin ◽  
Mingshu Wu ◽  
Dulin Kong ◽  
Zhongxiang Zhu ◽  
Jie Jiang ◽  
...  
Keyword(s):  
Green Synthesis ◽  
Aqueous Medium ◽  
One Pot ◽  
Betti Base ◽  
Adenine Derivatives

scholarly journals Synthesis of a Novel Series of Cu(I) Complexes Bearing Alkylated 1,3,5-Triaza-7-phosphaadamantane as Homogeneous and Carbon-Supported Catalysts for the Synthesis of 1- and 2-Substituted-1,2,3-triazoles

Nanomaterials ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 2702
Author(s):  
Ivy L. Librando ◽  
Abdallah G. Mahmoud ◽  
Sónia A. C. Carabineiro ◽  
M. Fátima C. Guedes da Silva ◽  
Carlos F. G. C. Geraldes ◽  
...  
Keyword(s):  
Aqueous Medium ◽  
Sodium Azide ◽  
Supported Catalysts ◽  
Cycloaddition Reaction ◽  
Water Soluble ◽  
Terminal Alkynes ◽  
One Pot ◽  
Catalytic Systems ◽  
Immobilized Catalyst ◽  
High Yields

The N-alkylation of 1,3,5-triaza-7-phosphaadamantane (PTA) with ortho-, meta- and para-substituted nitrobenzyl bromide under mild conditions afforded three hydrophilic PTA ammonium salts, which were used to obtain a new set of seven water-soluble copper(I) complexes. The new compounds were fully characterized and their catalytic activity was investigated for the low power microwave assisted one-pot azide–alkyne cycloaddition reaction in homogeneous aqueous medium to obtain disubstituted 1,2,3-triazoles. The most active catalysts were immobilized on activated carbon (AC), multi-walled carbon nanotubes (CNT), as well as surface functionalized AC and CNT, with the most efficient support being the CNT treated with nitric acid and NaOH. In the presence of the immobilized catalyst, several 1,4-disubstituted-1,2,3-triazoles were obtained from the reaction of terminal alkynes, organic halides and sodium azide in moderate yields up to 80%. Furthermore, the catalyzed reaction of terminal alkynes, formaldehyde and sodium azide afforded 2-hydroxymethyl-2H-1,2,3-triazoles in high yields up to 99%. The immobilized catalyst can be recovered and recycled through simple workup steps and reused up to five consecutive cycles without a marked loss in activity. The described catalytic systems proceed with a broad substrate scope, under microwave irradiation in aqueous medium and according to “click rules”.

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