Enzymatic Desymmetrization of Prochiral 2-Substituted-1,3-propanediols:  A Practical Chemoenzymatic Synthesis of a Key Precursor of SCH51048, a Broad-Spectrum Orally Active Antifungal Agent

1997 ◽  
Vol 62 (22) ◽  
pp. 7736-7743 ◽  
Author(s):  
Brian Morgan ◽  
David R. Dodds ◽  
Aleksey Zaks ◽  
David R. Andrews ◽  
Ricardo Klesse
Keyword(s):  
Broad Spectrum ◽  
Antifungal Agent ◽  
Chemoenzymatic Synthesis ◽  
Enzymatic Desymmetrization ◽  
Orally Active

Highly stereoselective access to novel 2,2,4-substituted tetrahydrofurans by halocyclization: Practical chemoenzymatic synthesis of Sch 51048, a broad-spectrum orally active antifungal agent

1995 ◽  
Vol 36 (11) ◽  
pp. 1787-1790 ◽  
Author(s):  
Anil K Saksena ◽  
Viyyoor M Girijavallabhan ◽  
Raymond G Lovey ◽  
Russell E Pike ◽  
Haiyan Wang ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Antifungal Agent ◽  
Chemoenzymatic Synthesis ◽  
Orally Active

Sch 51048, a novel broad-spectrum orally active antifungal agent: Synthesis and preliminary structure-activity profile

1995 ◽  
Vol 5 (2) ◽  
pp. 127-132 ◽  
Author(s):  
Anil K Saksena ◽  
Viyyoor M Girijavallabhan ◽  
Raymond G Lovey ◽  
Jagdish A Desai ◽  
Russell E Pike ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Antifungal Agent ◽  
Activity Profile ◽  
Structure Activity ◽  
Orally Active

ChemInform Abstract: Sch 51048, a Novel Broad-Spectrum Orally Active Antifungal Agent: Synthesis and Preliminary Structure-Activity Profile.

ChemInform ◽  
2010 ◽  
Vol 26 (24) ◽  
pp. no-no
Author(s):  
A. K. SAKSENA ◽  
V. M. GIRIJAVALLABHAN ◽  
R. G. LOVEY ◽  
J. A. DESAI ◽  
R. E. PIKE ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Antifungal Agent ◽  
Activity Profile ◽  
Structure Activity ◽  
Orally Active

Enzymatic desymmetrization of meso cis-2,6- and cis,cis-2,4,6-substituted piperidines. Chemoenzymatic synthesis of (5S,9S)-(+)-indolizidine 209D

1999 ◽  
Vol 10 (16) ◽  
pp. 3117-3122 ◽  
Author(s):  
Robert Chênevert ◽  
Ghodsi Mohammadi Ziarani ◽  
Marie Pascale Morin ◽  
Mohammed Dasser
Keyword(s):  
Chemoenzymatic Synthesis ◽  
Enzymatic Desymmetrization
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