A One-Step Ring Transformation/Ring Annulation Approach to Pyrrolo[2,3-d]pyrimidines. A New Synthesis of the Potent DHFR Inhibitor TNP-351

Edward C. Taylor; Hemantkumar H. Patel; Jong-Gab Jun

doi:10.1021/jo964010n

A One-Step Ring Transformation/Ring Annulation Approach to Pyrrolo[2,3-d]pyrimidines. A New Synthesis of the Potent DHFR Inhibitor TNP-351

The Journal of Organic Chemistry ◽

10.1021/jo964010n ◽

1996 ◽

Vol 61 (17) ◽

pp. 6082-6082

Author(s):

Edward C. Taylor ◽

Hemantkumar H. Patel ◽

Jong-Gab Jun

Keyword(s):

Ring Transformation ◽

New Synthesis ◽

One Step

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ChemInform Abstract: One-Step Ring Transformation/Ring Annulation Approach to Pyrrolo(2,3-d) pyrimidines. A New Synthesis of the Potent DHFR Inhibitor TNP-351.

ChemInform ◽

10.1002/chin.199610211 ◽

2010 ◽

Vol 27 (10) ◽

pp. no-no

Author(s):

E. C. TAYLOR ◽

H. H. PATEL ◽

J.-G. JUN

Keyword(s):

Ring Transformation ◽

New Synthesis ◽

One Step

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A One-Step Ring Transformation/Ring Annulation Approach to Pyrrolo[2,3-d]pyrimidines. A New Synthesis of the Potent Dihydrofolate Reductase Inhibitor TNP-351

The Journal of Organic Chemistry ◽

10.1021/jo00126a017 ◽

1995 ◽

Vol 60 (21) ◽

pp. 6684-6687 ◽

Cited By ~ 24

Author(s):

Edward C. Taylor ◽

Hemantkumar H. Patel ◽

Jong-Gab Jun

Keyword(s):

Dihydrofolate Reductase ◽

Reductase Inhibitor ◽

Ring Transformation ◽

New Synthesis ◽

One Step

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ChemInform Abstract: A New Synthesis of the Tricyclic Benzoxazine Derivative by One-Step Reductive Cyclization of Ethyl 3-Ethoxy-2-[3-acetonyloxy-4,5-difluoro-2-nitrobenzoyl]acrylate.

ChemInform ◽

10.1002/chin.199950225 ◽

2010 ◽

Vol 30 (50) ◽

pp. no-no

Author(s):

Young Ho Moon ◽

Soon Bang Kang ◽

Bong Young Chung ◽

Youseung Kim

Keyword(s):

Reductive Cyclization ◽

New Synthesis ◽

One Step

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Reactions of Ketene Acetals. IV. A New Synthesis of α-Pyrones. III

Canadian Journal of Chemistry ◽

10.1139/v75-028 ◽

1975 ◽

Vol 53 (2) ◽

pp. 201-208 ◽

Cited By ~ 9

Author(s):

Alain Bélanger ◽

Paul Brassard

Keyword(s):

New Synthesis ◽

One Step ◽

Ketene Acetals ◽

Mechanism Of The Reaction

A simple one-step synthesis of α-pyrones and 3-chloro-α-pyrones from β-functionalized α, β-enones and ketene acetals has been devised. The method has also been adapted to the preparation of some 4-methoxy-α-pyrones. Finally the mechanism of the reaction has been investigated.

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Ring transformation of heterocyclic compounds with weak nucleophiles. 22. Novel pyrimidine rearrangement reaction. A new synthesis of 4-formylimidazoles

The Journal of Organic Chemistry ◽

10.1021/jo00316a024 ◽

1981 ◽

Vol 46 (3) ◽

pp. 608-610 ◽

Cited By ~ 9

Author(s):

C. Gonczi ◽

Z. Swistun ◽

H. C. Van der Plas

Keyword(s):

Heterocyclic Compounds ◽

Ring Transformation ◽

New Synthesis ◽

Rearrangement Reaction

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ChemInform Abstract: A NEW SYNTHESIS OF PYRIMIDO(5,4-E)-AS-TRIAZINE 4-OXIDES AND THEIR RING TRANSFORMATION TO PYRROLO(3,2-D)PYRIMIDINES

Chemischer Informationsdienst ◽

10.1002/chin.198329217 ◽

1983 ◽

Vol 14 (29) ◽

Author(s):

S. NISHIGAKI ◽

H. KANAZAWA ◽

Y. KANAMORI ◽

M. ICHIBA ◽

K. SENGA

Keyword(s):

Ring Transformation ◽

New Synthesis

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ChemInform Abstract: Ring Transformation of 4-Amino- and 4-N-(Substituted)amino-1H-1,5-benzodiazepine-3-carbonitriles with Hydroxylamine. A New Synthesis of Benzimidazolidine and Isoxazole Derivatives.

ChemInform ◽

10.1002/chin.198941170 ◽

1989 ◽

Vol 20 (41) ◽

Author(s):

Y. OKAMOTO ◽

K. TAKAGI

Keyword(s):

Ring Transformation ◽

New Synthesis ◽

Isoxazole Derivatives

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Ring transformation of 4-amino and 4-N-(substituted)amino-1H-1,5-benzodiazepine-3-carbonitriles with hydroxylamine. A new synthesis of benzimidazolidine and isoxazole derivatives

Journal of Heterocyclic Chemistry ◽

10.1002/jhet.5570260202 ◽

1989 ◽

Vol 26 (2) ◽

pp. 277-279 ◽

Cited By ~ 7

Author(s):

Yoshihisa Okamoto ◽

Kaname Takagi

Keyword(s):

Ring Transformation ◽

New Synthesis ◽

Isoxazole Derivatives

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One Step α-Deoxygenation of Unprotected Aldonolactones using Samarium Diiodide-THF/H2O System - A New Synthesis of 2-Deoxy-D-Ribose

Synlett ◽

10.1055/s-1994-23034 ◽

1994 ◽

Vol 1994 (10) ◽

pp. 861-862 ◽

Cited By ~ 26

Author(s):

Stephen Hanessian ◽

Christian Girard

Keyword(s):

Samarium Diiodide ◽

System A ◽

New Synthesis ◽

One Step

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ChemInform Abstract: A New Synthesis of Alkyl 1-Alkyl-2-methylpyrrole-3-carboxylates by Ring Transformation of 2-Chloro-2-acetimidoylbutyrolactones.

ChemInform ◽

10.1002/chin.199933131 ◽

2010 ◽

Vol 30 (33) ◽

pp. no-no

Author(s):

Bart Kesteleyn ◽

Erick Rosas Alonso ◽

Christian Stevens ◽

Yves Dejaegher ◽

Maria Peristeropoulou ◽

...

Keyword(s):

Ring Transformation ◽

New Synthesis

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